21. HIPOTÁLAMO

22. CORPO MAMILAR

25. QUIASMA ÓPTICO

28. TÚBER CINÉRIO

31. INFUNDÍBULO

71. Thalamic reductions in children with chromosome 22q11.2 deletion syndrome Joel P. Bish,1,CA Vy Nguyen,1 Lijun Ding,1 Samantha Ferrante1 and Tony J. Simon1,2 Children with chromosome 22q11.2 deletion syndrome (22q) sufer from physical And behavioral dysfunctions, including neuroanatomical anomalies, visuo-spatial processing de¢cits, and increased risk for psychopathology.Reduced total brain volume, parietal lobe volume, and cerebellar volumes, enlarged ventricles, and increased basal ganglia volumes have been reported. Since previous literature has related the pulvinar nucleus of the thalamus to visuo-spatial processing, we compared the thalamic volume in children with 22q to typically developing controls. Children with 22q showed a signi¢cant reduction of the thalamus compared with normally developing children, specifically in the posterior portion of the thalamus, including the pulvinar nucleus.These results provide the first evidence for a potential relationship between posterior thalamic reductions and the characteristic visuo-spatial deficits demonstrated in this group.

72. Functional Magnetic Resonance Imaging During Auditory Verbal Relatives of Persons with Schizophrenia: A Pilot StudyWorking Memory in Nonpsychotic Heidi W. Thermenos, Larry J. Seidman, Hans Breiter, Jill M. Goldstein, Julie M. Goodman, Russell Poldrack, Stephen V. Faraone, and Ming T. Tsuang Background: First-degree relatives of persons with schizophrenia carry elevated genetic risk for the illness and show deficits on high-load information processing tasks. We used functional magnetic resonance imaging (fMRI) to test whether nonpsychotic relatives show altered functional activation in the prefrontal cortex (PFC), thalamus, hippocampus, and anterior cingulate during a working memory task requiring interference resolution . Results: Compared with control subjects, relatives showed greater task-elicited activation in the PFC and the anterior and dorsomedial thalamus. When task performance was controlled, relatives showed significantly greater activation in the anterior cingulate. When effects of other potentially confounding variables were controlled, relatives generally showed significantly greater activation in the dorsomedial thalamus and anterior cingulate. Conclusions: This pilot study suggests that relatives of persons with schizophrenia have subtle differences in brain function in the absence of psychosis. These differences add to the growing literature identifying neurobiological vulnerabilities to schizophrenia.