Este documento discute as diferenças individuais no funcionamento do sistema de temporização circadiana humano. Algumas pessoas são mais matutinas e outras mais vespertinas, dependendo de fatores como fase, amplitude e período endógeno. Existem também diferenças genéticas que afetam os genes expressos nos osciladores circadianaos.
O exercício tornou-se uma unanimidade na promoção da saúde e melhora da qualidade de vida, diminuindo os riscos de desenvolvimento de doenças crônicas e atuando como fator-chave para aumentar a longevidade.
O exercício tornou-se uma unanimidade na promoção da saúde e melhora da qualidade de vida, diminuindo os riscos de desenvolvimento de doenças crônicas e atuando como fator-chave para aumentar a longevidade.
O exercício tornou-se uma unanimidade na promoção da saúde e melhora da qualidade de vida, diminuindo os riscos de desenvolvimento de doenças crônicas e atuando como fator-chave para aumentar a longevidade.
O exercício tornou-se uma unanimidade na promoção da saúde e melhora da qualidade de vida, diminuindo os riscos de desenvolvimento de doenças crônicas e atuando como fator-chave para aumentar a longevidade.
Slides Lição 10, Central Gospel, A Batalha Do Armagedom, 1Tr24.pptxLuizHenriquedeAlmeid6
Slideshare Lição 10, Central Gospel, A Batalha Do Armagedom, 1Tr24, Pr Henrique, EBD NA TV, Revista ano 11, nº 1, Revista Estudo Bíblico Jovens E Adultos, Central Gospel, 2º Trimestre de 2024, Professor, Tema, Os Grandes Temas Do Fim, Comentarista, Pr. Joá Caitano, estudantes, professores, Ervália, MG, Imperatriz, MA, Cajamar, SP, estudos bíblicos, gospel, DEUS, ESPÍRITO SANTO, JESUS CRISTO, Com. Extra Pr. Luiz Henrique, 99-99152-0454, Canal YouTube, Henriquelhas, @PrHenrique
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Slides Lição 10, Central Gospel, A Batalha Do Armagedom, 1Tr24.pptxLuizHenriquedeAlmeid6
Slideshare Lição 10, Central Gospel, A Batalha Do Armagedom, 1Tr24, Pr Henrique, EBD NA TV, Revista ano 11, nº 1, Revista Estudo Bíblico Jovens E Adultos, Central Gospel, 2º Trimestre de 2024, Professor, Tema, Os Grandes Temas Do Fim, Comentarista, Pr. Joá Caitano, estudantes, professores, Ervália, MG, Imperatriz, MA, Cajamar, SP, estudos bíblicos, gospel, DEUS, ESPÍRITO SANTO, JESUS CRISTO, Com. Extra Pr. Luiz Henrique, 99-99152-0454, Canal YouTube, Henriquelhas, @PrHenrique
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
Deus ajuda quem cedo madruga
1. Deus ajuda só a quem
cedo madruga?
Diferenças Individuais no Funcionamento
do Sistema de Temporização Circadiana
Humano
Leandro Duarte
Departamento de Fisiologia e
Biofísica-ICB/USP
2. REVISÃO
Sistema de temporização circadiana
Osciladores
Ciclos externos
Ritmo
aparente
4. Diferenças Individuais
Fase
Amplitude e Mesor
Período endógeno M I V n
12% 61% 27% 172
CRONOTIPOS DIFERENTES: 16% 60% 24% 2135
Matutinos 15% 73% 12% 6631
Vespertinos
Intermediários 34% 51% 15% 522
5. PRINCIPAIS CARACTERÍSTICAS
Facilidade acordar 1as horas da manhã
Dificuldade vigília além do horário de dormir
Estabilidade semana x final de semana (CVS)
M Boa eficiência de sono; menor sonolência diurna
Menos cochilos, menores problemas de atenção
Menores indisposições emocionais
Menor uso de cafeína e benzodiazepínicos
Atraso do início do sono
Atraso do início da vigília
Instabilidade semana x final de semana (CVS)
V Baixa eficiência de sono; maior sonolência diurna
Mais cochilos, maiores problemas de atenção
Maiores indisposições emocionais
Maior uso de cafeína e benzodiazepínicos
6. Diferenças de fase
R 2h 11min Baehr, 2000 Temperatura
R.A 2h 34min
R.Rc 2h 07min Kerkhoff & Van Dongen,1996
Oral 4h 36min
R.A 1h 08min Bailey, 2001
R.Rc 3h Waterhouse, 2001
Oral 1h12min Horne & Ostberg, 1976
7. Diferenças de fase
Cortisol
P.A 55 min Bailey, 2001
Melatonina
S.Rc 2h 06min Griefahn, 2002
8. Outros ritmos...
Dinâmica do débito urinário
Alerta subjetivo = 9 h
MATUTINO
8
final Natale & Cicogna, 2002
VESPERTINO
6
ml/min
final
4 Kerkhof & Van Dongen 1996
2 = 6 h
4h RC
inicial inicial
0
Duarte & Menna-Barreto, 2004
Humor
Kerkhof, 1998
Necessidade de monitoramento de outros ritmos
9. Questionários para
identificação
•Horne & Ostberg, 1976
japonês
adolescentes
adultos jovens alemão português
crianças espanhol
diferenciação semana
e final de semana francês
italiano
www.crono.icb.usp.br/cronotipo
10. Classificação
alerta
temperatura
Natale & Cicogna, 2002
11. Estudando as diferenças
Relação de fase entre os ritmos
Período endógeno
Genes de expressão rítmica
17. Relação de fase
entre os ritmos
Dividindo o STC em dois:
• Ritmos mais plásticos: ciclo vigília/sono, volume urinário,
resposta a teste de desempenho
• Ritmos mais rígidos: temperatura central, sono REM, cortisol
18. Neurofisiologia
Melatonina
NÚCLEO PARAVENTRICULAR PINEAL
ÁREA PRÉ-ÓPTICA NSQ HIPOTÁLAMO
POSTERIOR
Tálamo
Prosencéfalo Basal
Temperatura
corporal Ciclo vigília/sono Atividade/Repouso
Moore & Danchenko, 2002
24. MECANISMO MOLECULAR TIM CRY
P
DOS OSCILADORES
TIM PER
tim TIM
P P
P
PER PER PER
PER CRY
CLOCK BMAL cry CRYs
CKI epsilon
per PERs
+ E-box
25. MECANISMO MOLECULAR
DOS OSCILADORES
tim TIM CRY
P P
TIM PER
PER
P
P
PER PER
PER CRY
CLOCK BMAL cry CRYs
CKI epsilon
per PERs
+ E-box
26. MECANISMO MOLECULAR
DOS OSCILADORES
P
TIM PER P
TIM CRY
P
P PER
PER
PER
PER CRY
-
CLOCK BMAL cry CRYs
CKI epsilon
per PERs
+ E-box
27. MECANISMO MOLECULAR
DOS OSCILADORES
P
TIM PER P
TIM CRY
P
P PER
PER
PER
PER CRY
-
CLOCK BMAL cry
CKI epsilon
per
E-box
28. Genes de expressão rítmica
per1 2548G e per1 2548A Katzenberg et al., 1999
Katzenberg et al., 1998
* clock 3111C e clock 3111T Robiliards, 2002
tim 2634G e tim 2634A Pedrazzoli et al., 1998
Mutação Síndrome da fase avançada do sono
per2
Toh, 2001
per3 Síndrome da fase atrasada do sono
Ascher, 2003
29. MECANISMO MOLECULAR
DOS OSCILADORES TIM CRY
P
tim
TIM TIM PER
P
P P
TIM CRY P
TIM PER
P P PER PER PER
PER CRY
PER PER
CRY
PER
-
clock bmal cry CRYs
CKI epsilon
per PERs
+ E-box
30. Perspectivas de estudos….
Relação de fase entre diferentes
ritmos
Capacidade de arrastamento
Período endógeno
Curva de
Resposta dependente de fase
Diferenças morfológicas nos genes de expressão rítmica
31. Projetos em
desenvolvimento:
PROSUL
“Relação de fase entre os ritmos
MODELO de temperatura periférica, atividade/
MATEMÁTICO repouso e o ciclo claro-escuro em
“Cronotipos Humanos: cronotipos extremos”
aplicação de modelo Duarte, L., Areas, R., Menna-Barreto
matemático”
Duarte, L., Lopes, J. R. MODELO
ANIMAL
HUMOR “Plasticidade do
CRONOTIPOS Sistema de
“Variação Circadiana de Temporização em
Humor: Comparação Roedores da Espécie
Entre Diferentes Trinomis yonenagae:
Cronotipos.” Comparação entre
Porto, R., Duarte, L., Indivíduos Matutinos
Menna-Barreto, L. DEPRESSÃO e Vespertinos”
“Associação da Depressão com Duarte, L., Spinelli, E.,
o Cronotipo do Indivíduo” Menna-Barreto, L.
Mesquita, E., Duarte,L., Menna-Barreto, L.
33. Enquanto os vespertinos não
sincronizam…
Maior exposição aos
perigos associados à
Sonolência em horários vida noturna
“impróprios”
Letargia e ou
estados depressivos
34. OBRIGADO PELA ATENÇÃO!
lduarte@icb.usp.br
“A máxima igualdade é aquela que permite
o exercício das diferenças”