Comparação de Preços - Papelaria
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Este documento lista 40 itens de papelaria com suas respectivas unidades de medida, marcas e preços de menor e maior valor encontrados. Os itens variam de apontadores, borrachas, cadernos, canetas, colas, lápis e outros materiais escolares, além de suas especificações como cor, tamanho e quantidade.
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Tabela de preços
O documento lista preços de produtos gráficos como cartões de visita, convites, cartazes, calendários, certificados e outros itens em diferentes tamanhos e quantidades, com valores variando de R$0,25 a R$285,00 dependendo do material e especificações de cada item.
80223977 school surveillance
The document discusses the threat to privacy posed by the government's increasing use of surveillance technologies without proper constitutional regulations. It notes that while some surveillance methods have existed for some time, many new technologies like drones, GPS tracking, and data collection have increased after 9/11. This has allowed unprecedented access to people's personal information without their consent. To protect both security and freedom, reasonable laws and policies are needed to limit government access, collection, and retention of individuals' data. The document recommends regulating aerial surveillance technologies more stringently to prevent unjustified invasions of privacy.
Health benefits of spices - Just for Hearts
Spices have several health benefits. They stimulate salivation, acid secretion, and digestive enzymes, improving digestion and reducing flatulence. Some spices also act as preservatives. Commonly used spices include turmeric, black pepper, cumin, coriander, ginger, garlic, and cinnamon. Other beneficial spices are cloves, cardamom, nutmeg, and fenugreek. To learn more about risk factors for heart disease and personalized consultations, visit the eClinics website.
Dose-dependent hepatotoxicity effects of Zinc oxide nanoparticles
Abstract
Objective(s):
Zinc oxide nanoparticles (ZNP) are increasingly used in sunscreens, biosensors, food additives and pigments. In this study the effects of ZNP on liver of rats was investigated.
Materials and Methods:
Experimental groups received 5, 50 and 300 mg/kg ZNP respectively for 14 days. Control group received only distilled water. ALT, AST and ALP were considered as biomarkers to indicate hepatotoxicity. Lipid peroxidation (MDA), SOD and GPx were detected for assessment of oxidative stress in liver tissue. Histological studies and TUNEL assay were also done.
Results:
Plasma concentration of zinc (Zn) was significantly increased in 5 mg/kg ZNP-treated rats. Liver concentration of Zn was significantly increased in the 300 mg/kg ZNP-treated animals. Weight of liver was markedly increased in both 5 and 300 mg/kg doses of ZNP. ZNP at the doses of 5 mg/kg induced a significant increase in oxidative stress through the increase in MDA content and a significant decrease in SOD and GPx enzymes activity in the liver tissue. Administration of ZNP at 5 mg/kg induced a significant elevation in plasma AST, ALT and ALP. Histological studies showed that treatment with 5 mg/kg of ZNP caused hepatocytes swelling, which was accompanied by congestion of RBC and accumulation of inflammatory cells. Apoptotic index was also significantly increased in this group. ZNP at the dose of 300 mg/kg had poor hepatotoxicity effect.
Conclusion:
It is concluded that lower doses of ZNP has more hepatotoxic effects on rats, and recommended to use it with caution if there is a hepatological problem.
A comparative study about toxicity of CdSe quantum dots on reproductive syste...
A comparative study about toxicity of CdSe quantum dots on reproductive syste...Nanomedicine Journal (NMJ)
This study examined the toxicity of CdSe quantum dots (QDs) and CdSe:ZnS QDs on the reproductive system of mice. Mice were injected with doses of 10, 20, and 40 mg/kg of CdSe QDs or CdSe:ZnS QDs. Histological analysis found that the 40 mg/kg dose of CdSe:ZnS QDs caused abnormal growth of seminiferous tubes, impaired spermatogenesis, and a decrease in testis weight, sperm count, and testosterone levels compared to controls. The CdSe:ZnS QDs at 40 mg/kg also decreased sperm density in the epididymis. This suggests that, contrary to previous reports, theCombined effects of PEGylation and particle size on uptake of PLGA particles ...
Combined effects of PEGylation and particle size on uptake of PLGA particles ...Nanomedicine Journal (NMJ)
Abstract
Objective:
At the present study, relationship between phagocytosis of PLGA particles and combined effects of particle size and surface PEGylation was investigated.
Materials and Methods:
Microspheres and nanospheres (3500 nm and 700 nm) were prepared from three types of PLGA polymers (non-PEGylated and PEGylation percents of 9% and 15%). These particles were prepared by solvent evaporation method. All particles were labeled with FITC-Albumin. Interaction of particles with J744.A.1 mouse macrophage cells, was evaluated in the absence or presence of 7% of the serum by flowcytometry method.
Results:
The study revealed more phagocytosis of nanospheres. In the presence of the serum, PEGylated particles were phagocytosed less than non-PEGylated particles. For nanospheres, this difference was significant (P<0/05) and their uptake was affected by PEGylation degree. In the case of microsphere formulation, PEGylation did not affect the cell uptake. In the serum-free medium, the bigger particles had more cell uptake rate than smaller ones but the cell uptake rate was not influenced by PEGylation.
Conclusion:
The results indicated that in nanosized particles both size and PEgylation degree could affect the phagocytosis, but in micron sized particles just size, and not the PEGylation degree, could affect this.The role of surface charge of ISCOMATRIX nanoparticles on the type of immune ...
The role of surface charge of ISCOMATRIX nanoparticles on the type of immune ...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
ISCOMATRIX vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite or tumor. In the present study, we investigated the role of ISCOMATRIX charge in induction of a Th1 type of immune response and protection against Leishmania major infection in BALB/c mice.
Materials and Methods:
Positively and negatively charged ISCOMATRIX were prepared. BALB/C mice were immunized subcutaneously, three times with 2-week intervals, with different ISCOMATRIX formulations. Soluble Leishmania antigens (SLA) were mixed with ISCOMATRIX right before injection. The extent of protection and type of immune response were studied in different groups of mice.
Results:
The group of mice immunized with negatively charged ISCOMATRIX showed smaller footpad swelling upon challenge with L. major and the highest IgG2a production compared with positively charged one. The mice immunized with positively charged ISCOMATRIX showed the lowest splenic parasite burden compared to the other groups. Cytokine assay results indicated that the highest level of IFN- γ and IL-4 secretion was observed in the splenocytes of mice immunized with negatively charged ISCOMATRIX as compared to other groups.
Conclusion:
The results indicated that ISCOMATRIX formulations generate an immune response with mixed Th1/Th2 response that was not protective against challenge against L. major.Recomendados
Tabela de preços
O documento lista preços de produtos gráficos como cartões de visita, convites, cartazes, calendários, certificados e outros itens em diferentes tamanhos e quantidades, com valores variando de R$0,25 a R$285,00 dependendo do material e especificações de cada item.
80223977 school surveillance
The document discusses the threat to privacy posed by the government's increasing use of surveillance technologies without proper constitutional regulations. It notes that while some surveillance methods have existed for some time, many new technologies like drones, GPS tracking, and data collection have increased after 9/11. This has allowed unprecedented access to people's personal information without their consent. To protect both security and freedom, reasonable laws and policies are needed to limit government access, collection, and retention of individuals' data. The document recommends regulating aerial surveillance technologies more stringently to prevent unjustified invasions of privacy.
Health benefits of spices - Just for Hearts
Spices have several health benefits. They stimulate salivation, acid secretion, and digestive enzymes, improving digestion and reducing flatulence. Some spices also act as preservatives. Commonly used spices include turmeric, black pepper, cumin, coriander, ginger, garlic, and cinnamon. Other beneficial spices are cloves, cardamom, nutmeg, and fenugreek. To learn more about risk factors for heart disease and personalized consultations, visit the eClinics website.
Dose-dependent hepatotoxicity effects of Zinc oxide nanoparticles
Abstract
Objective(s):
Zinc oxide nanoparticles (ZNP) are increasingly used in sunscreens, biosensors, food additives and pigments. In this study the effects of ZNP on liver of rats was investigated.
Materials and Methods:
Experimental groups received 5, 50 and 300 mg/kg ZNP respectively for 14 days. Control group received only distilled water. ALT, AST and ALP were considered as biomarkers to indicate hepatotoxicity. Lipid peroxidation (MDA), SOD and GPx were detected for assessment of oxidative stress in liver tissue. Histological studies and TUNEL assay were also done.
Results:
Plasma concentration of zinc (Zn) was significantly increased in 5 mg/kg ZNP-treated rats. Liver concentration of Zn was significantly increased in the 300 mg/kg ZNP-treated animals. Weight of liver was markedly increased in both 5 and 300 mg/kg doses of ZNP. ZNP at the doses of 5 mg/kg induced a significant increase in oxidative stress through the increase in MDA content and a significant decrease in SOD and GPx enzymes activity in the liver tissue. Administration of ZNP at 5 mg/kg induced a significant elevation in plasma AST, ALT and ALP. Histological studies showed that treatment with 5 mg/kg of ZNP caused hepatocytes swelling, which was accompanied by congestion of RBC and accumulation of inflammatory cells. Apoptotic index was also significantly increased in this group. ZNP at the dose of 300 mg/kg had poor hepatotoxicity effect.
Conclusion:
It is concluded that lower doses of ZNP has more hepatotoxic effects on rats, and recommended to use it with caution if there is a hepatological problem.
A comparative study about toxicity of CdSe quantum dots on reproductive syste...
A comparative study about toxicity of CdSe quantum dots on reproductive syste...Nanomedicine Journal (NMJ)
This study examined the toxicity of CdSe quantum dots (QDs) and CdSe:ZnS QDs on the reproductive system of mice. Mice were injected with doses of 10, 20, and 40 mg/kg of CdSe QDs or CdSe:ZnS QDs. Histological analysis found that the 40 mg/kg dose of CdSe:ZnS QDs caused abnormal growth of seminiferous tubes, impaired spermatogenesis, and a decrease in testis weight, sperm count, and testosterone levels compared to controls. The CdSe:ZnS QDs at 40 mg/kg also decreased sperm density in the epididymis. This suggests that, contrary to previous reports, theCombined effects of PEGylation and particle size on uptake of PLGA particles ...
Combined effects of PEGylation and particle size on uptake of PLGA particles ...Nanomedicine Journal (NMJ)
Abstract
Objective:
At the present study, relationship between phagocytosis of PLGA particles and combined effects of particle size and surface PEGylation was investigated.
Materials and Methods:
Microspheres and nanospheres (3500 nm and 700 nm) were prepared from three types of PLGA polymers (non-PEGylated and PEGylation percents of 9% and 15%). These particles were prepared by solvent evaporation method. All particles were labeled with FITC-Albumin. Interaction of particles with J744.A.1 mouse macrophage cells, was evaluated in the absence or presence of 7% of the serum by flowcytometry method.
Results:
The study revealed more phagocytosis of nanospheres. In the presence of the serum, PEGylated particles were phagocytosed less than non-PEGylated particles. For nanospheres, this difference was significant (P<0/05) and their uptake was affected by PEGylation degree. In the case of microsphere formulation, PEGylation did not affect the cell uptake. In the serum-free medium, the bigger particles had more cell uptake rate than smaller ones but the cell uptake rate was not influenced by PEGylation.
Conclusion:
The results indicated that in nanosized particles both size and PEgylation degree could affect the phagocytosis, but in micron sized particles just size, and not the PEGylation degree, could affect this.The role of surface charge of ISCOMATRIX nanoparticles on the type of immune ...
The role of surface charge of ISCOMATRIX nanoparticles on the type of immune ...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
ISCOMATRIX vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite or tumor. In the present study, we investigated the role of ISCOMATRIX charge in induction of a Th1 type of immune response and protection against Leishmania major infection in BALB/c mice.
Materials and Methods:
Positively and negatively charged ISCOMATRIX were prepared. BALB/C mice were immunized subcutaneously, three times with 2-week intervals, with different ISCOMATRIX formulations. Soluble Leishmania antigens (SLA) were mixed with ISCOMATRIX right before injection. The extent of protection and type of immune response were studied in different groups of mice.
Results:
The group of mice immunized with negatively charged ISCOMATRIX showed smaller footpad swelling upon challenge with L. major and the highest IgG2a production compared with positively charged one. The mice immunized with positively charged ISCOMATRIX showed the lowest splenic parasite burden compared to the other groups. Cytokine assay results indicated that the highest level of IFN- γ and IL-4 secretion was observed in the splenocytes of mice immunized with negatively charged ISCOMATRIX as compared to other groups.
Conclusion:
The results indicated that ISCOMATRIX formulations generate an immune response with mixed Th1/Th2 response that was not protective against challenge against L. major.Synthesis of silver nanoparticles and its synergistic effects in combination ...
Synthesis of silver nanoparticles and its synergistic effects in combination ...Nanomedicine Journal (NMJ)
Abstract
Objectives:
Biofilms are communities of bacteria attached to surfaces through an external polymeric substances matrix. In the meantime, Acinetobacterbaumannii is the predominant species related to nosocomial infections. In the present study, the effect of silver nanoparticles alone and in combination with biocides and imipenem against planktonic and biofilms of A. baumannii was assessed.
Materials and Methods:
Minimum inhibitory concentrations (MICs) of 75 planktonic isolates of A. baumannii were determined by using the microdilution method as described via clinical and laboratory standards institute (CLSI). Among all strains, 10 isolates which formed strong biofilms were selected and exposed to silver nanoparticles alone and in combination with imipenem, bismuth ethandithiol (BisEDT) and bismuth propanedithiol (BisPDT) to determine minimum biofilm inhibitory concentrations (MBIC). Subsequently, minimum biofilm eradication concentrations (MBECs) of silver nanoparticles alone and in combination with imipenem against mature biofilm of the isolates were evaluated.
Results:
Results showed that 29.3% of isolates were susceptible to silver nanoparticles and could inhibit the growth and eradicate biofilms produced by the isolates. For this reason, ∑FIC, ∑FBIC and ∑FBEC ≤ 0.05 were reported which shows synergism between silver nanoparticles and imipenem against not only planktonic cells but also inhibition and eradication of biofilms. The results of ∑FBIC >2 indicated to antagonistic impacts between silver nanoparticles and BisEDT/BisPDT against biofilms.
Conclusion:
It can be concluded that silver nanoparticles alone can inhibit biofilm formation but in combination with imipenem are more effective against A. baumannii in planktonic and biofilm forms.auction_news_media_pack_2016
The document describes Auction News, a company that provides three advertising platforms - a magazine, website, and email marketing - to auctioneers. It has advertised for leading auctioneers for over 50 years. The magazine reaches over 26,000 subscribers weekly. The website receives 32,000 monthly visits. Email marketing can boost auction response by up to 500%. Advertising across the three platforms provides maximum exposure for auctioneers.
Internazionali Bnl: i tabelloni
This document provides the results from the 2015 Internazionali BNL d'Italia tennis tournament in Rome, Italy from May 9-17, 2015 played on red clay. It details the singles and doubles draws. In singles, Novak Djokovic defeated Roger Federer in the men's final while Serena Williams defeated Simona Halep in the women's final. The financial commitment for the tournament was €3,830,295.
Functionalization of carbon nanotubes and its application in nanomedicine: A ...
Functionalization of carbon nanotubes and its application in nanomedicine: A ...Nanomedicine Journal (NMJ)
Abstract
This review focuses on the latest developments in applications of carbon nanotubes (CNTs) in medicine. A brief history of CNTs and a general introduction to the field are presented.
Then, surface modification of CNTs that makes them ideal for use in medical applications is highlighted. Examples of common applications, including cell penetration, drug delivery, gene delivery and imaging, are given. At the same time, there are concerns about their possible adverse effects on human health, since there is evidence that exposure to CNTs induces toxic effects in experimental models. However, CNTs are not a single substance but a growing family of different materials possibly eliciting different biological responses. As a consequence, the hazards associated with the exposure of humans to the different forms of CNTs may be different. Understanding the structure–toxicity relationships would help towards the assessment of the risk related to these materials. Finally, toxicity of CNTs, are discussed. This review article overviews the most recent applications of CNTs in Nanomedicine, covering the period from 1991 to early 2015.Synthesis of graphene oxide-TiO2 nanocomposite as an adsorbent for the enrich...
Synthesis of graphene oxide-TiO2 nanocomposite as an adsorbent for the enrich...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
In our study, graphene oxide-TiO2 nanocomposite (GO/TiO2) was prepared and used for the enrichment of rutin from real samples for the first time.
Materials and Methods:
The synthesized GO/TiO2 was characterized by X-ray diffraction, scanning electron microscopy, and FT-IR spectra. The enrichment process is fast and highly efficient. The factors including contact time, pH, and amount of GO/TiO2 affecting the adsorption process were studied.
Results:
The maximum adsorption capacity for ciprofloxacin was calculated to be 59.5 mg/g according to the Langmuir adsorption isotherm. The method yielded a linear calibration curve in the concentration ranges from 15 to 200 μg/L for the rutin with regression coefficients (r2) of 0.9990. The limits of detection (LODs, S/N=3) and limits of quantification (LOQs, S/N=10) were found to be 8 μg/Land 28 μg/L, respectively. Both the intra-day and inter-day precisions (RSDs) were < 10% .
Conclusion:
The developed approach offered wide linear range, and good reproducibility. Owing to the diverse structures and unique characteristic, GO/TiO2 possesses great potential in the enrichment and analysis of trace rutin in real aqueous samples.Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...
Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A.
Material and Methods:
Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfactants Tween 80, benzalkonium chloride and Pluronic and evaluated for pH, particle size, entrapment efficiency, differential scanning calorimetry (DSC), stability and drug release. Also, Draize test was used to evaluate the irritation of rabbit eye by formulations.
Results:
All formulations showed a small mean size that is well suited for ocular application. Also it was observed that the particle size decreased with increase in the amount of surfactant. Drug entrapment increased with increasing amount of surfactant. It was shown that initial and final drug release can be controlled by the ratio and the total amount of surfactants, respectively.
Conclusion:
It was concluded that the use of Tween 80 and Pluronic in the formualtions with a proper ratio does not show eye irritation and could be useful to achieve a suitable nanosuspension of vitamin A as a novel ocular delivery system.3 enrique vila
Enrique Vila-Matas es un escritor catalán nacido en 1948 en Barcelona. Es autor de una amplia obra narrativa que ha sido traducida a 33 idiomas, incluido el catalán. También ha publicado varios libros de ensayo literario. A lo largo de su carrera ha recibido numerosos premios literarios importantes por sus novelas.
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Este manual presenta pautas para mejorar la atención de clientes en empresas turísticas. Explica que conocer al cliente es fundamental, y provee métodos como encuestas, grupos focales y revisión de quejas. También cubre ofrecer servicios de calidad, comunicación efectiva, selección y capacitación de personal, liderazgo, trabajo en equipo, mejora de procesos, y resolución de conflictos. El objetivo es que las empresas apliquen estas herramientas para establecer programas de calidad que satisfagan a los clientes y
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O documento apresenta os resultados de uma pesquisa de preços de materiais escolares realizada em janeiro de 2016 em 10 estabelecimentos em Florianópolis. Foram pesquisados os preços de 57 itens como cadernos, pastas, papéis, lápis e canetas. A tabela mostra o preço mínimo, máximo e médio de cada item, além da variação percentual de preços entre os estabelecimentos.
Pesquisa de preço de material escolar em SC
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Catálogo COEPAD - 2013
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Inventário esmalteria foz jk
O documento fornece um inventário detalhado dos produtos e equipamentos de uma esmaltaria, incluindo 763 unidades de esmaltes no valor de R$5.961,00, móveis e utensílios no valor de R$24.204,00 e adesivos/películas para unhas no valor de R$805,00.
Custos7
O documento lista 11 itens de material de limpeza e compara os preços de três fornecedores diferentes. Fornece detalhes como quantidade, unidade, descrição do item, preço unitário e valor total para cada fornecedor. Ao final, soma os valores totais de cada fornecedor e indica o valor médio total.
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O documento apresenta uma pesquisa de preços de materiais escolares realizada em diversas papelarias da cidade. São listados vários produtos como cadernos, canetas, colas e seus preços em cada estabelecimento, além de indicar o preço máximo, mínimo e médio encontrado para cada item.
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Estrutura Pedagógica - Laboratório de Educação a Distância.ppt
Teorias da Aprendizagem
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EAD
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Manual da UFCD_10949_Lojas e-commerce no-code_pronto para envio, via email, formato editável.
email: formacaomanuaisplus@gmail.com
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Destaque
Synthesis of silver nanoparticles and its synergistic effects in combination ...
Synthesis of silver nanoparticles and its synergistic effects in combination ...Nanomedicine Journal (NMJ)
Abstract
Objectives:
Biofilms are communities of bacteria attached to surfaces through an external polymeric substances matrix. In the meantime, Acinetobacterbaumannii is the predominant species related to nosocomial infections. In the present study, the effect of silver nanoparticles alone and in combination with biocides and imipenem against planktonic and biofilms of A. baumannii was assessed.
Materials and Methods:
Minimum inhibitory concentrations (MICs) of 75 planktonic isolates of A. baumannii were determined by using the microdilution method as described via clinical and laboratory standards institute (CLSI). Among all strains, 10 isolates which formed strong biofilms were selected and exposed to silver nanoparticles alone and in combination with imipenem, bismuth ethandithiol (BisEDT) and bismuth propanedithiol (BisPDT) to determine minimum biofilm inhibitory concentrations (MBIC). Subsequently, minimum biofilm eradication concentrations (MBECs) of silver nanoparticles alone and in combination with imipenem against mature biofilm of the isolates were evaluated.
Results:
Results showed that 29.3% of isolates were susceptible to silver nanoparticles and could inhibit the growth and eradicate biofilms produced by the isolates. For this reason, ∑FIC, ∑FBIC and ∑FBEC ≤ 0.05 were reported which shows synergism between silver nanoparticles and imipenem against not only planktonic cells but also inhibition and eradication of biofilms. The results of ∑FBIC >2 indicated to antagonistic impacts between silver nanoparticles and BisEDT/BisPDT against biofilms.
Conclusion:
It can be concluded that silver nanoparticles alone can inhibit biofilm formation but in combination with imipenem are more effective against A. baumannii in planktonic and biofilm forms.auction_news_media_pack_2016
The document describes Auction News, a company that provides three advertising platforms - a magazine, website, and email marketing - to auctioneers. It has advertised for leading auctioneers for over 50 years. The magazine reaches over 26,000 subscribers weekly. The website receives 32,000 monthly visits. Email marketing can boost auction response by up to 500%. Advertising across the three platforms provides maximum exposure for auctioneers.
Internazionali Bnl: i tabelloni
This document provides the results from the 2015 Internazionali BNL d'Italia tennis tournament in Rome, Italy from May 9-17, 2015 played on red clay. It details the singles and doubles draws. In singles, Novak Djokovic defeated Roger Federer in the men's final while Serena Williams defeated Simona Halep in the women's final. The financial commitment for the tournament was €3,830,295.
Functionalization of carbon nanotubes and its application in nanomedicine: A ...
Functionalization of carbon nanotubes and its application in nanomedicine: A ...Nanomedicine Journal (NMJ)
Abstract
This review focuses on the latest developments in applications of carbon nanotubes (CNTs) in medicine. A brief history of CNTs and a general introduction to the field are presented.
Then, surface modification of CNTs that makes them ideal for use in medical applications is highlighted. Examples of common applications, including cell penetration, drug delivery, gene delivery and imaging, are given. At the same time, there are concerns about their possible adverse effects on human health, since there is evidence that exposure to CNTs induces toxic effects in experimental models. However, CNTs are not a single substance but a growing family of different materials possibly eliciting different biological responses. As a consequence, the hazards associated with the exposure of humans to the different forms of CNTs may be different. Understanding the structure–toxicity relationships would help towards the assessment of the risk related to these materials. Finally, toxicity of CNTs, are discussed. This review article overviews the most recent applications of CNTs in Nanomedicine, covering the period from 1991 to early 2015.Synthesis of graphene oxide-TiO2 nanocomposite as an adsorbent for the enrich...
Synthesis of graphene oxide-TiO2 nanocomposite as an adsorbent for the enrich...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
In our study, graphene oxide-TiO2 nanocomposite (GO/TiO2) was prepared and used for the enrichment of rutin from real samples for the first time.
Materials and Methods:
The synthesized GO/TiO2 was characterized by X-ray diffraction, scanning electron microscopy, and FT-IR spectra. The enrichment process is fast and highly efficient. The factors including contact time, pH, and amount of GO/TiO2 affecting the adsorption process were studied.
Results:
The maximum adsorption capacity for ciprofloxacin was calculated to be 59.5 mg/g according to the Langmuir adsorption isotherm. The method yielded a linear calibration curve in the concentration ranges from 15 to 200 μg/L for the rutin with regression coefficients (r2) of 0.9990. The limits of detection (LODs, S/N=3) and limits of quantification (LOQs, S/N=10) were found to be 8 μg/Land 28 μg/L, respectively. Both the intra-day and inter-day precisions (RSDs) were < 10% .
Conclusion:
The developed approach offered wide linear range, and good reproducibility. Owing to the diverse structures and unique characteristic, GO/TiO2 possesses great potential in the enrichment and analysis of trace rutin in real aqueous samples.Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...
Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A.
Material and Methods:
Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfactants Tween 80, benzalkonium chloride and Pluronic and evaluated for pH, particle size, entrapment efficiency, differential scanning calorimetry (DSC), stability and drug release. Also, Draize test was used to evaluate the irritation of rabbit eye by formulations.
Results:
All formulations showed a small mean size that is well suited for ocular application. Also it was observed that the particle size decreased with increase in the amount of surfactant. Drug entrapment increased with increasing amount of surfactant. It was shown that initial and final drug release can be controlled by the ratio and the total amount of surfactants, respectively.
Conclusion:
It was concluded that the use of Tween 80 and Pluronic in the formualtions with a proper ratio does not show eye irritation and could be useful to achieve a suitable nanosuspension of vitamin A as a novel ocular delivery system.3 enrique vila
Enrique Vila-Matas es un escritor catalán nacido en 1948 en Barcelona. Es autor de una amplia obra narrativa que ha sido traducida a 33 idiomas, incluido el catalán. También ha publicado varios libros de ensayo literario. A lo largo de su carrera ha recibido numerosos premios literarios importantes por sus novelas.
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Destaque (9)
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- 1. ÍTEM Produto Unidade Estabelecimentos Papelaria C Menos Preço / Marca Maior Preço / Marca 1 ApontadorSimples Unidade R$ 0,90 - Maped R$ 1,80 - Faber Castell 2 Apontadorcomdepósito Unidade R$ 2,50 - Cis R$ 4,50 - Faber Castell 3 Borracha Branca 20 Unidade R$ 0,60 - Mercur R$ 0,60 - Mercur 4 Borracha Branca 40 Unidade R$ 0,75 - Fernandinho R$ 0,90 - Mercur 5 Borracha RetangularVerde Unidade R$ 1,20 - Mercur R$ 1,20 - Mercur 6 CadernoCapa Dura 1 matéria96 folhas Unidade R$ 6,90 - Foroni R$ 18,90 - Tilibra 7 CadernoCapa Dura 10 matérias Unidade R$ 11,50 - Foroni R$ 21,50 - Tilibra 8 CadernoCapa Dura 15 matérias Unidade R$ 17,90 - Foroni R$ 29,90 - Credeal 9 CadernoCapa Dura 20 matérias Unidade Não Tem Não Tem 10 Cadernode DesenhoCapaDura Pequeno96 folhas Unidade R$ 1,80 - Credeal R$ 1,80 - Credeal 11 Cadernode DesenhoCapaDura Grande 96 folhas Unidade R$ 7,40 - Credeal R$ 11,90 - Tilibra 12 CalculadoraSimples Unidade Não Tem Não Tem 13 CanetaEsferográfica"TipoBic" Unidade R$ 0,95 - Bic R$ 6,50 - Pilot 14 CanetaMarca Texto Unidade R$ 2,20 - Mercur R$ 2,90 - Pilot 15 ColaBranca 90g Unidade R$ 2,10 - Leo e Leo R$ 4,90 - Tenaz 16 ColaBastão 90g Unidade R$ 1,20 - Maripel R$ 2,90 - Cis 17 CompassoMetal Unidade R$ 5,50 - Goller R$ 6,90 - Waleu 18 Dicionáriode Português - Pequeno Unidade R$ 3,90 - Aurélio R$ 13,90 - Michaelis 19 Estojocom 1 zípersimples Unidade R$ 8,90 - Urban R$ 39,90- Monster High 20 Fitaadesiva- rolo 50m Unidade R$ 2,90 R$ 2,90 21 Grafite 0,5 mmC/12 Unidade R$ 1,40 - Cis R$ 3,50 - Faber Castell 22 Grafite 0,7 mmC/12 Unidade R$ 1,40 - Cis R$ 3,50 - Faber Castell 23 GrampeadorPequeno Unidade R$ 7,90 - Munix R$ 11,50 - Cis 24 Grampo para Grampeadorc/1000 Caixa R$ 1,90 - VMP R$ 1,95 - Bacchi 25 Isopor1,00 x 1,20 metros - 10 mm Placa R$ 2,90 R$ 2,90 26 Isopor1,00 x 1,20 metros - 15 mm Placa R$ 3,90 R$ 3,90 27 Lápisde Cor 12 cores"Grande" Unidade R$ 5,90 - Multicolor R$ 16,90 - Faber Castell 28 Lápispretonº 2 Unidade R$ 0,75 - Bic R$ 1,25 - Staedtler 29 Lapiseira0,5 mm Unidade R$ 4,50 - Adeck R$ 8,90 - Adeck 30 Lapiseira0,7 mm Unidade R$ 1,90 - Tris R$ 8,90 - Tris 31 Mochila Unidade R$ 39,90 - Holly R$ 179,90 - Xerius 32 Papel AlmaçoA4 Folha R$ 0,15 R$ 0,15 33 Papel CartolinaBranca Folha R$ 0,50 R$ 0,50 34 Papel Sulfite A4brancocom 100 folhas Pacote R$ 3,89 - Seninha R$ 3,89 - Seninha 35 Papel Sulfite A4brancocom 500 folhas Pacote Não Tem Não Tem 36 RéguaPlásticaTransparente - 30 cm Unidade R$ 0,50 - Dello R$ 2,70 - Dello 37 Tesousasempontapequena Unidade R$ 1,70 - Adeck R$ 3,70 - Tris 38 Tintaguache 6 cores pequena Caixa R$ 3,60 - Acrilex R$ 3,60 - Acrilex 39 Xerox "preto" Folha R$ 0,25 R$ 0,25 40 Xerox "colorido" Folha R$ 0,35 R$ 0,35