1. Influenza A(H1N1)
Luke Jon Rodríguez Girón

2. Breve Historía
• Influenza A viruses
o RNA Dependent RNA Polymerasa
o nonsense
o single-stranded segmented RNA viruses.
• There are labeled according to an H number for
the type of hemagglutinin and an N number for
the type of neuraminidase.
o Sixteen different H antigens (H1 to H16)
o Nine different N antigens (N1 to N9).
• Influenza A H1N1
o Began In the 1918
 virus came over the poultry barrier
and began to infect humans

3. Proteínas y Sus Funciones
• The 2009 Influenza A virus has a total genome
size is 13,588 bases in its RNA that codifies
eleven proteins
o HA
 Determines host cell
o NA
 Encodes neuraminidase
o NP
 Encodes nucleoprotein
o M1
 A matrix protein
o M2
 A matrix protein
o NS1
 A structural protein

4. Proteínas y Sus Funciones
o NEP
 A strucural protein
o PA
 Encodes a RNA polymerase
o PB1
 Encodes a RNA polymerase
o PB1-F2
 The protein formed by PB1
o PB2
 Encodes a RNA polymerase

5. Replicación
The ends of the RNA strands are partially complementary,
allowing them to bond to each other by hydrogen bonds. After
transcription from sense to nonsense RNA the RNA sense strands
get the cellular 5' cap added by cap snatching, which involves the
viral protein NS1 binding to the cellular pre mRNAs. The cap is
then cleaved from the cellular pre-mRNA using a second viral
protein, PB2. The short oligonucleotide cap is then added to the
influenza RNA sense strands, allowing its processing as
messenger RNA by ribosomes. The RNA sense strands also serve
for synthesis of RNA sense strands for new virus particles. The
RNA synthesis and its assembly with the nucleoprotein takes
place in the cell nucleus, the synthesis of proteins takes place in
the cytoplasm. The assembled virion cores leave the nucleus and
migrate towards the cell membrane, with patches of viral
transmembrane proteins (hemagglutinin, neuraminidase and M2
proteins) and an underlying layer of the M1 protein, and bud
through these patches, releasing finished enveloped viruses into
the extracellular fluid.

6. Síntomas
• Symptoms include
o fever
o cough
o sore throat
o body aches
o headache
o chill
o fatigue
• The 2009 outbreak has shown
an increased percentage of
patients reporting diarrhea and
vomiting.

7. Prevención
• Prevention of pig to human transmission
o Using face mask when dealing with infected
animals
o The use of vaccines on swine to prevent their
infection is a major method of limiting swine to
human transmission
o wearing gloves when working with sick animals
• Prevention of human to human transmission
o frequent washing of hands with soap and water
or with alcohol-based hand sanitizers
o disinfecting household surfaces, which can be
done effectively with a diluted chlorine bleach
solution
o not touching your eyes, nose or mouth with
your hands
o Cover your mouth when coughing or sneezing,
o Anyone with flu-like symptoms such as a
sudden fever, cough or muscle aches should
stay away from work or public transportation
and should contact a doctor for advice

9. Refencias
Google Images www.google.com
Shen, J. ; Ma, J. and Wang Q.. August 2009. Evolutionary Trends
of A(H1N1) Influenza VirusHemagglutinin Since 1918. PLoS
One. Vol 4. No 11.
Maurer-Stroh, S.; Ma, J.; Lee, R. T. C.; Sirota, F.L. and Frank E..
May 2009.Influenza A (H1N1) . Biology Direct. Vol 4. No 18.

10. Muchas Garcias