Liquid Crystal Phase & it's uses

1. Liquid Crystals
Presented by- Mr.Shreyas R.
Kulkarni
M.Pharm.(Pharmaceutics)
Roll no.-11
Guided by –Dr.Vishal V. Pande sir
HOD (Pharmaceutics,PG Dept.)
S.C.P.E.R, Kopargaon
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2. • Learning Objectives
1. Introduction
2. History
3. Classification
4. Nematic Liquid Crystals
5. Smectic Liquid Crystals
6. Cholesteric Liquid Crystals
7. Discotic Liquid crystals
8. Applications
9. Conclusion
10. University Questions
11. References
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3. Basic Terminology:
Mesophase- A Phase lying between solid &
liquid formed by changing amount of order in
sample.
Anisotropy- Object or substance having a
physical property which has a different value when
measured in different directions.
Isotropy- When the properties of material are the
same in all direction, the material is said to be
Isotropy.
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4. •Introduction
• Liquid Crystals are matter in state which has properties
between the convensional liquids and solids.
• It’s shows Anisotropy.
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5. • History
Anchen Scientist Otto Lehman
 On 3 May,1888 Lehman with
help of Freidrich Reinitzer
published their first result on
Liquid crystals.
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7. • History
•In early of 1962 the RCA
Laboratories firstly used the
electronic display made with
liquid crystals.
•Ex. cyanobiphenyl
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8. LiquidCrystals
Lyotropic Liq.
crystal
Thermotropic Liq.
Crystal
Polymeric Liq.
Crystal
• Classification
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9. • In solvent
• Depends on Temperature,
Concentration, salt, alcohol
• Structures:
Lamellar, Hexagonal etc
For Ex. 1) Soap, it is the day to
day life example of lyotropic
liquid crystals.
2) Phospholipids (present in cell
membrane)
1. Lyotropic liquid crystals
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10. 2.Thermotropic Liquid Crystals
• These are the liquid crystaline phases that
occures due to change in temprature range.
• Absence of solvent
• Rigid organic molecules
• Depends on Temperature
• Structures:
a) Smectic
b) Nematic
c) Cholesteric
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11. These are basically
the mesogenic unit is
incorporated in the
polymeric molecule.
Ex. electrical and
mechanical parts,
food containers, and
any other applications
requiring chemical
inertness and high
strength.
3. Polymeric Liquid Crystals
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12. Classification of Thermotropic Liq.
Crystal
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13. Phases of Liquid Crystals
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14. • Nematic Phase
• No possitional order
• Molecules in same
direction
• When temperatures is
incrase molecules will
be allign immediately
• In nematic crystal phase
molecules are arranged
paralell
• Ex. Cyanobiphenyl
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15. • Smectic Phase
• This phase can be
reached at lower
temperatures than the
nematic phase.
• Not all positional
order is destroyed
when a crystal melts
to form a smectic
liquid crystal
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16. • Cholesteric Phase
• Chiral nematic phase
• This phase exhibits the twisting of
the molecules perpendicular to the
director.
• Ex. Cholesterol Benzoate:LC 147C
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Applications:
1) sensors
2) Thermometer
3) fashion fabrics that
change colour with
temperature
4) display devices

17. • Columnar
(Discotic phase)
Columnar (or
discotic) liquid
crystals are
different from the
previous types
because they are
shaped like discs
instead of long
rods.
17
Discotic phase
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Liquid
Crystal
• Having 3 Dimensional Order
Smectic
A
• Having 0 Order
• Translational & Rotational Motion
Nematic
• Diffuse Out of the Latice Like Structure
• Layer like arrangement
Isotropic
• Having 0 Order as well
• Liquid
As Temperature Increases………

19. Applications
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1.Pharma drugs as Liquid crystals.
Ex.
a) Nafodixine HCL.
b) Palmitolyl propranolol HCL.
c) Itraconazole.
2.Liquid Crystals as a
solubility enhancers.
Ex. Fenoprofen Calcium
• Pharmaceutical Application
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3. Novel approach for topical
drug deleivary
For eg. Zaltoprofen (an
NSAID)
4. Liquid Crystals in
Cosmaceuticals
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22. 5. Liquid Crystal Thermometers
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• Liquid-crystal
thermometers use
liquid crystals that
change color in
response to
temperature
changes.
• Numbers on the
partitions indicate
temperatures
according to the
amount of heat
present.

23. •Flat screen television
•Laptop screens
•Switchable windows
• Other Uses of Liquid Crystals
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• Digital Clocks
• Digital Calculator
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Why DURACELL so much famous?

26. Conclusion
Today, Thanks to the scientists Reinitzer,
Lehmann and their followers, we know that
literally thousands of substances have a diversity
of other states. Some of them have been found
very usable in several technical innovations,
among which liquid crystal screens and liquid
crystal thermometers may be the best known.
The many applications of LCs in Pharma
industries made many revolutions, which
become very beneficial for the society.
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27. Not yet…….
But Might be ask in this year!!!!
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•Reference
1. P. Gaikwad, Maya t. Desai. Liquid crystalline phase & its pharma applications
international journal of pharma research & review, dec 2013; 2(12):40-52
2. Pande v., Nayak s., Kendre p., Patil p. And sagar k. Fabrication and
characterization of zaltoprofen loaded Lyotropic liquid crystalline gel(received 20
august 2015) (accepted 20 november 2015) indian drugs 53 (03) march 2016
3.Theory of liquid crystals,http://www.springer.com/978-3-319-00857-8
4. Denis Andrienko, Introduction to liquid crystalsInternational Max Planck
Research School Modelling of soft matter,11-15 September 2006, Bad
Marienberg September 14, 2006
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5. Theory of liquid crystals
http://www.worldscientific.com
6. I. Tadwee, Dr.S. Shahi, V. Ramteke, I. Syed. Liquid
Crystals Pharmaceutical Application: A Review; Volume 1,
issue2 (2012), 06-11
7. A. P. Lodha, G. P. Jadhav and V. V. Pande . Liquid
Crystals As A Cubo-Hexagonal Topical Controlled Drug
Delivery System:Pharmacophore 2014, Vol. 5 (3), 430-
441 USA CODEN: PHARM7 ISSN 2229-5402
8.The Classification Of Liquid Crystal,
http://photonicswiki.org/images.
9.Application of liquid Crystal
http://saffron.pharmabiz.com/article/detnews.asp?articleid
=48939&sectionid=46
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