28. Neurodegenerative diseases
• Parkinsonism
• It is defined as a neurodegenerative disorder of
extrapyramidal Nigrostriatal pathway
• Therapy : MAO & COMT inhibitors
• Alzhiemers
• loss of cholinergic neurons results in shrinkage of the brain
and other pathological conditions
• Therapy : Nootropic agents
• Antiamyloid antibodies
• NMDA receptor blocker
30. CONCLUSION
• The optimistic view is that a better understanding of
the particular functions of the many molecular subtypes
of these targets, and the design of more subtype-
specific ligands, will lead to future breakthroughs.
31. References
1. Bleakman, D., Lodge, D., 1998. Neuropharmacology
of AMPA and kainate receptors. Neuropharmacology
37, 187–204. (Review giving molecular and functional
information on these receptors),
2. Barnard, E.A., 2000. The molecular architecture of
GABAA receptors. In: Möhler, H. (Ed.), Pharmacology of
GABA and glycine neurotransmission. Handbook of
experimental pharmacology 150. Springer-Verlag, Berlin,
pp. 79–100. (Authoritative review on the molecular subtypes of
GABAA receptors
32. 3. Bylund, D.B., 2007. Receptors for norepinephrine and
signal transduction pathways. In: Ordway, G.A., Schwartz,
M.A., Frazer, A. (Eds.), Brain norepinephrine. Cambridge
University Press, London.
Head, G.A., Mayorov, D.N., 2006. Imidazoline receptors,
novel agents and therapeutic potential. Cardiovasc.
Hematol. Agents Med. Chem. 4, 17–32. (Provides an update
on the elusive imidazoline receptors