10. Receptor Molecules In
Synapses
After that neurotransmitters
interact with the next cell. This way
the nervous impulse is transmitted
between 2 neurons.
10
12. o Exocytose vesicles, spontaneously,
merge with the pre synaptic
membrane, propagating a nervous
impulse to the next neuron.
12
13. o Substance that alters
nervous impulse
transmission.
13
Adenosine
14. o It is a secreted protein
in humans.
o Encourage the growth
and differentiation of
new neurons.
o BDNF itself is
important for long-
term memory.
14
15. o It plays an important role
in the consolidation of
information from short to
long-term memory.
15
16. The goal of this experiment was to address weather BDNF
effects on mIPSC frequency are dependent on A2ARs
activation.
16
19. 19
o Removal of the
brain
o Dissection of the
hippocampus
o Acute brain slices
technique
o 300µm slices
o 2 to 4 weeks old
o Anesthetization
o Decapitation
26. Adenosine A2A receptor agonist
Adenosine Activates
Track B
receptors
Potentiates
Effects of
BDNF
26
27. 10 minutes of control time - with TTX, KYN, and SCH
40 minutes of data registration of the inhibitory response
10 min || 40 min
TTX, KYN,
SCH (100 nM)
BDNF 10
(ng/mL)
27
36. o Adition of SCH prevents the effects of BDNF;
o Results from a single experimente;
o Plenty of room for Biomedical Engeneering to
improve essencial equipement.
36