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Extended Spectrum Beta Lactamases Esbl

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T
Temujin Chavez

Beta-lactamases confer resistance to penicillin, 1st 2nd & 3rd generation cephalosporins, and aztreonam

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Extended Spectrum Beta-lactamases Temujin T. Chavez, M.D. LCDR MC USN Infectious Diseases Fellow
ESBL Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686
ESBL Introduction ,[object Object],[object Object],[object Object],Clin Microbiol Rev.18;2005:657-689.
ESBL Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PPID, 6th ed. 2005
ESBL Types
ESBL Types-SHV ,[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686.
ESBL-TEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686.
ESBL Other Types ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686.
B-lactamases other types ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Microb Drug Restance. 2006;12:223-230.
ESBL In Vitro Susceptibility
ESBL In Vitro Susceptiblity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686 J Clin Microbiol.2001;39:2206-2212.
ESBL In Vitro Susceptibility ,[object Object],[object Object],[object Object],[object Object],J Clin Microbiol. 2001;39:2206-2212.
ESBL In Vitro Susceptibility ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Clin Microbiol. 2001;39:2206-2212.
ESBL In Vitro Susceptibilty ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Clin Microbiol. 2001;39:2206-2212.
ESBL In Vitro Susceptibilty ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Infect. 2008;14:169-174.
ESBL Epidemiology
ESBL Epidemiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686.
Risk Factors
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],J Clinical Microbiol. 2004;42:1089-1094
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],J Clinical Micobiol. 2004;42:1089-1094.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Clinical Microbiol. 2004;42:1089-1094.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],CID. 2005;40:1317-1324.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],CID. 2005;40:1317-1324.
ESBL Risk Factors ,[object Object],[object Object],CID. 2005;40:1317-1324.
ESBL Risk Factors ,[object Object],[object Object],[object Object],CID. 2005;40:1317
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],Annals of Int Med. 2004;140:26-32.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],Annals of Int Med. 2004;140:26-32.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],Annals of Int Med. 2004;140:26-32.
ESBL Risk Factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ESBL Antibiotic Choice ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clin Microbiol Rev. 2005;18:657-686.
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Extended Spectrum Beta Lactamases Esbl

Notas do Editor

  1. Amp C associated with clinical failure when 3rd gen ceph used. In general, 4th gen ceph, cefepime, clinically useful against AmpC type organisms.
  2. Germany isolate with B-lactamase related to SHV-1
  3. Amp C associated with clinical failure when 3rd gen ceph used. In general, 4th gen ceph, cefepime, clinically useful against AmpC type organisms.
  4. Inoculum effect-K pneumo with mic 0.25ug/ml when 10*5cfu/ml but increases to >64ug/ml when 10*7 cfu/ml
  5. NNIS=National Nosocomial Infection Surveillance National Nosocomial Infections Surveillance. 2002. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 to June 2002, issued August 2002. Am J Infect. Control 30:458-475.
  6. NO clonal relatedeness discovered Unable to determine if plasmid mediated resistance Data not present shows that no clonal relationship between outpt and inpt samples