its research papr prsntatn ,, which tryed to findout the true relatnshp btwn h.pylori infection and stomach cancer

1. H. pyloriSeropositivity before Age 40 and Subsequent
Risk of Stomach Cancer: A Glimpse of the True
Relationship?
SSrreeeejjiitthh BBeenn ccss
UU33BBIITT1122005511

2. IInnttrroodduuccttiioonn
ppeeooppllee ddoonn’’tt kknnooww aabboouutt tthhiiss ssiilleenntt
iinnffeeccttiioonn uunnttiill tthheeyy ssttaarrtt ssuuffffeerriinngg ffrroomm
ggaassttrriittiiss oorr tthhee ppaaiinnffuull eeffffeeccttss ooff uullcceerrss..
IIttss pprreesseennccee iiss hhaarrdd ttoo ddeetteecctt..
SSpprreeaaddss tthhrroouugghh tthhee ccoonnssuummppttiioonn ooff
ccoonnttaammiinnaatteedd ffoooodd aanndd wwaatteerr..

3. atrophic pangastritis
a process of chronic
inflammation of the stomach
mucosa,
superficial gastritis
intestinal
metaplasia and
associated
hypochlorhydria
chronic inflammation of the lamina
propria, limited to the outer third of
the mucosa
an intermediate precancerous
gastric lesion in the gastric cancer
cascade from chronic gastritis

4. chronic atrophic gastritis, occurring at a much higher rate
in infected destroys the microorganism’s natural niche and
may lead to disappearance of H. pylori ,resulted in
underestimation of the strength of the association
90%

5. case-control study of about 400 000 individuals
Swedish Institute for
Infectious Disease Control
Biobank (since1957)
investigations of the immunity against
infections in the Swedish population
samples that have been analyzed
stored at 22 'C.
samples from 93 462 unique individuals
(with valid
National Registration Numbers [NRNs]
between age 16-40
Malmo¨ Microbiology
Biobank (since 1969).
majority of the samples are
submitted for diagnosis of blood-borne
viral infections, e.g.
hepatitis virus, (over 500,000
samples). About
100,000 samples emanate from
population-based
serological screening for viral
infections and rubella immunity
during pregnancy.samples from
374 598 unique
individuals (with valid NRNs)
collected between age 16 and 40

6. Results :

7. Compared with the ‘clean’ reference group, those seronegative for both
Hp-CSA and CagA antibodies,
subjects seropositive with either Hp-CSA or CagA antibodies had
a close to 10-fold increased risk (95% CI 2.9–32.9), and the
increased risk further rose to close to 50-fold among those
seropositive with both antibodies (95% CI 5.8–407.4).

8. Discussion
H. pyloriwas classified as a class I carcinogen for
stomach cancer by the International Agency for Research on
Cancer (IARC)
H. pylori have been
shown to promote the production of inflammatory mediators such
as IL-1 and TNF-a, both potent suppressors of stomach juice
secretion.
resulting in enhanced inflammation in the mucosa of the corpus, followed by
parietal cell
destruction and irreversible Hypochlorhydria "