How fat is managed in our human body , and how by altering the leptin pathway we can treat bulimia, anorexia and obesity like disorders.

1. LEPTIN & OBESITY
Dr. Smrutiranjan Patanaik

2.  OBESITY – A GLOBAL HEALTH PROBLEM
 RECENT LIPOSTATIC HYPOTHESIS HAS GIVEN
ATTENTION TO LEPTIN
 DEFECTIVE OB/OB GENE IN MICE REVEALS
ASSOCIATION OF LEPTIN WITH OBESITY
 KNOCKOUT OF DB/DB GENE PRODUCES
DECREASE IN LEPTIN RECEPTORS
 LEPTIN RESISTANCE IS ASSOCIATED WITH OBESITY

4.  A PEPTIDE HORMONE
 167 AMINO ACIDS
 M.wt. 16kDa
 SECRETED BY
ADIPOCYTES
 DISCOVERED BY
FRIEDMAN IN 1994

12.  LEPTIN OPERATES AS PART OF A FEEDBACK
LOOP BY WHICH THE SIZE OF THE BODY FAT
DEPOTS CAN OPERATE THROUGH A HUMORAL
LINK TO REGULATE FOOD INTAKE

13. THANK YOU