Optimal design & Population mod pyn.pptxPawanDhamala1
This document discusses optimal design and population modeling. It begins with an introduction to optimal design, noting that it allows parameters to be estimated without bias and with minimum variance. The advantages of optimal design are that it reduces experimentation costs by allowing statistical models to be estimated with fewer runs. It then describes different types of optimal designs such as A, C, D, and E optimality. The document next discusses population modeling, explaining that it is a tool for integrating data to aid drug development decisions. It notes the key components of population models are structural models, stochastic models, and covariate models. Structural models describe the response over time using algebraic or differential equations, while stochastic models describe variability and covariate models influence factors like dem
MPH07 Computers in clinical development.pptxBhuminJain1
My topic is computers in clinical development. There are various ways pf collecting data like pure paper based system, electronic based system and communication.
REGULATORY AND INDUSTRY VIEWS ON QbD, SCIENTIFICALLY BASED QbD- EXAMPLES OF A...Ardra Krishna
The pharmaceutical Quantity by Design (QbD) is a systemic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quantity risk management.
QbD has been adopted by U.S Food and Drug Administration (FDA) for the discovery, development and manufacture of drugs.
Quality- by- design (QbD) is a concept introduces by the International Conference on Harmonization (ICH) Q8 guidelines.
review of guidelines for herbal cosmetics by private bodies like cosmos with ...MoidulIslam17
review of guidelines for herbal cosmetics by private bodies like cosmos with respect to preservatives, emollients, foaming agents, emulsifiers and rheology modifiers.
hisory of computers in pharmaceutical research presentation.pptxDhanaa Dhoni
Computers have been used in pharmaceutical research and development since the 1940s. Early computers were large mainframe systems that were expensive and shared between organizations. By the 1960s, some pharmaceutical companies had acquired early computers like the IBM 650 to assist with scientific tasks. Today, computers are essential for tasks across the pharmaceutical industry from drug design and clinical trials to manufacturing, sales, and more. Advanced statistical modeling and software continue to be important tools in pharmaceutical research and development.
Optimal design & Population mod pyn.pptxPawanDhamala1
This document discusses optimal design and population modeling. It begins with an introduction to optimal design, noting that it allows parameters to be estimated without bias and with minimum variance. The advantages of optimal design are that it reduces experimentation costs by allowing statistical models to be estimated with fewer runs. It then describes different types of optimal designs such as A, C, D, and E optimality. The document next discusses population modeling, explaining that it is a tool for integrating data to aid drug development decisions. It notes the key components of population models are structural models, stochastic models, and covariate models. Structural models describe the response over time using algebraic or differential equations, while stochastic models describe variability and covariate models influence factors like dem
MPH07 Computers in clinical development.pptxBhuminJain1
My topic is computers in clinical development. There are various ways pf collecting data like pure paper based system, electronic based system and communication.
REGULATORY AND INDUSTRY VIEWS ON QbD, SCIENTIFICALLY BASED QbD- EXAMPLES OF A...Ardra Krishna
The pharmaceutical Quantity by Design (QbD) is a systemic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quantity risk management.
QbD has been adopted by U.S Food and Drug Administration (FDA) for the discovery, development and manufacture of drugs.
Quality- by- design (QbD) is a concept introduces by the International Conference on Harmonization (ICH) Q8 guidelines.
review of guidelines for herbal cosmetics by private bodies like cosmos with ...MoidulIslam17
review of guidelines for herbal cosmetics by private bodies like cosmos with respect to preservatives, emollients, foaming agents, emulsifiers and rheology modifiers.
hisory of computers in pharmaceutical research presentation.pptxDhanaa Dhoni
Computers have been used in pharmaceutical research and development since the 1940s. Early computers were large mainframe systems that were expensive and shared between organizations. By the 1960s, some pharmaceutical companies had acquired early computers like the IBM 650 to assist with scientific tasks. Today, computers are essential for tasks across the pharmaceutical industry from drug design and clinical trials to manufacturing, sales, and more. Advanced statistical modeling and software continue to be important tools in pharmaceutical research and development.
This document discusses in silico modeling techniques for predicting drug absorption and pharmacokinetic properties. It covers two main modeling approaches: quantitative approaches like pharmacophore modeling and QSAR which use statistical analysis of molecular descriptors to correlate structure to properties, and qualitative approaches. Specific techniques covered include modeling solubility, intestinal permeability, and factors like transporters and ionization state that influence absorption. The goal is to use these computational models to predict absorption and other pharmacokinetic properties early in drug discovery to improve candidate selection and reduce late-stage clinical failures.
The document discusses concepts, events, and biological processes involved in drug targeting. It defines drug targeting as selectively delivering pharmacologically active drugs to identified targets in therapeutic concentrations while restricting access to non-targets to minimize toxicity. It describes various strategies for drug targeting including chemical modifications, carrier-mediated delivery, and active targeting. It also outlines biological processes involved like cellular uptake, transport across epithelial barriers, extravasation into tissues, and lymphatic uptake that influence drug distribution. The presentation emphasizes how targeted delivery can improve efficacy and safety of drug therapy especially for cancer.
COMPUTER SIMULATIONS IN PHARMACOKINETICS & PHARMACODYNAMICSsagartrivedi14
Computer simulations in pharmacokinetics and pharmacodynamics can model the whole organism, isolated tissues, and individual organs. Whole organism simulations use lumped-parameter models that represent the body with a small number of differential equations, or physiological models that use more differential equations to describe organs in detail. Isolated tissue and organ simulations often use distributed blood tissue exchange models for organs like the heart and liver. These simulations aim to integrate organ-specific models with whole-body models to improve predictive capabilities in areas like pharmacokinetics.
Computational modeling in drug dispositionHimal Barakoti
The document discusses computational modeling of drug disposition. It covers modeling of drug absorption, distribution, excretion, and active transport. For drug absorption, it describes modeling of solubility, intestinal permeability, and transporters involved. It also discusses modeling approaches for distribution processes like volume of distribution, plasma protein binding, and blood-brain barrier permeability. Current challenges include better incorporating the effects of active transporters in models. The document emphasizes that while computational models are useful for predicting drug properties, fully accounting for complex biological factors remains difficult.
Computer simulations in pharmacokinetics and pharmacodynamicsGOKULAKRISHNAN S
This document discusses computer simulations in pharmacokinetics and pharmacodynamics. It describes how whole organism, isolated tissue, and organ simulations work. For whole organism simulations, two approaches are used: lumped-parameter PK-PD modeling which uses differential equations to model the system over time, and physiological modeling which attempts to model interacting organs in detail. Isolated tissue and organ simulations are also discussed, focusing on models of the heart, liver, kidney and brain. The challenges of complexity and model selection are addressed.
Computerized marketing can facilitate more efficient collection and dissemination of current market information compared to traditional phone-based methods. It could potentially eliminate 90% of the costs associated with negotiating sales. It may also increase competition by allowing traders to more easily communicate with each other. Previous computerized marketing systems have resulted in higher prices for growers, from both increased competition and improved operational efficiency, with cost savings being passed on to growers. A survey of industry participants found general support for developing a computerized marketing system to complement existing practices.
The document discusses various drug delivery systems including niosomes, aquasomes, and phytosomes. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer advantages over liposomes such as lower cost and greater stability. Aquasomes are three-layered nanoparticle structures consisting of a ceramic core coated with an oligosaccharide film that can deliver fragile molecules while maintaining their integrity. Phytosomes utilize phospholipids to surround active herbal constituents, improving their absorption and bioavailability compared to traditional herbal extracts.
Tumour targeting and Brain specific drug deliverySHUBHAMGWAGH
The document discusses tumor targeting and brain specific drug delivery. It provides an introduction to targeted drug delivery and outlines strategies for tumor targeting including passive targeting via the enhanced permeability and retention effect, active targeting using ligands, and triggered drug delivery responsive to microenvironment changes. It also discusses challenges of drug delivery to the brain posed by the blood-brain barrier and factors that affect crossing it, as well as diseases related to the brain and strategies to enhance brain-specific drug delivery.
The document discusses several key concepts related to drug transport and absorption:
1) The pH partition hypothesis states that acidic drugs are absorbed from acidic solutions and basic drugs from alkaline solutions, though some exceptions exist due to the microclimate pH near the membrane surface.
2) Tight junctions form a virtually impermeable barrier between cells, composed of sealing strands that prevent fluid passage.
3) According to Fick's first law, passive diffusion of solutes is determined by concentration gradients and membrane permeability. For ionizable drugs, the uncharged form is more permeable. The pH partition hypothesis relates permeability to pH and the fraction of uncharged molecules.
Computational modelling of drug disposition lalitajoshi9
computational modelling of drug disposition is the integral part of computer aided drug design. different kinds of tools being used in the prediction of drug disposition in human body. This topic in the CADD explains the details about the drug disposition, active transporters and tools.
The document describes electrosomes, which are lipid vesicles containing ion channel proteins that allow ion transport. Electrosomes consist of two compartments - an anode displaying enzymes for ethanol oxidation and a cathode displaying an oxygen-reducing enzyme. Enzymes containing dockerin modules are attached to cohesin sites on scaffoldin proteins and displayed on yeast cell surfaces. This allows electron transfer through enzymatic cascades for high fuel cell power output. Electrosomes show potential as drug delivery carriers by controlling drug release and targeting tissues selectively.
computer simulation in pharmacokinetics and pharmacodynamicsSUJITHA MARY
This document discusses the use of computer simulation in pharmacokinetics and pharmacodynamics at four different levels: whole organism, isolated tissues/organs, cellular, and protein/gene levels. At each level, mathematical models are used to represent biological processes and predict behavior over time. The goal is to better understand drug behavior and improve drug development by replacing animal and human trials with computer simulations. Challenges include integrating data from different structural levels and ensuring high quality input data.
This document summarizes ICH Q8 guidelines for pharmaceutical product development. It discusses key aspects of quality by design (QbD) like quality target product profiles, critical quality attributes, and critical process parameters. The document also outlines the contents recommended for the quality module in a common technical document, including drug substances, excipients, formulation development, manufacturing processes, containers and closures, microbiological attributes, and compatibility studies. The goal of QbD and ICH Q8 is to build quality into pharmaceutical products through scientific approaches and risk management during development.
Artificial intelligence robotics and computational fluid dynamics Chandrakant Kharude
The document discusses applications of artificial intelligence, robotics, and computational fluid dynamics in the pharmaceutical industry. It provides introductions and definitions for each technology, as well as their current and potential applications. Some key applications discussed include using AI for disease identification, personalized treatment, drug discovery/manufacturing, and clinical trials. Applications of robotics mentioned include use in research and development, packaging, sterile syringe filling, and laboratory automation. Current challenges and future directions are also addressed.
Computational modeling of drug dispositionPV. Viji
Computational modeling of drug disposition , Modeling techniques , Drug absorption , solubility , intestinal permeation , Drug distribution , Drug excretion , Active Transport , P-gp , BCRP , Nucleoside transporters , hPEPT1 , ASBT , OCT , OATP , BBB-choline transporter
This document discusses various compendial methods for drug dissolution testing. It begins by defining dissolution as the process where a solid substance solubilizes in a solvent, transferring mass from the solid surface to the liquid phase. It then describes the seven USP dissolution apparatus types and their applications for testing different drug products like tablets, capsules, modified release formulations and transdermal systems. The document provides details on factors that influence dissolution test design and the principles of operation for each apparatus type.
This document discusses computer aided formulation development and optimization techniques. It covers topics like optimization parameters, response surface curves, experimental designs, and factorial designs. Specifically, it defines optimization as making a design or system as effective as possible. It also describes types of experimental designs like factorial designs, which study the effects of varying multiple factors simultaneously. Full and fractional factorial designs are explained, with fractional designs requiring fewer runs by testing only a subset of the full factorial design combinations.
Industrial Engineering unit 4.Production planning and control Notes by badebhau.Er. Bade Bhausaheb
Production planning and control aims to efficiently and effectively manage operations in a manufacturing organization. It addresses issues like low productivity, inventory management, and resource utilization. The key objectives of production planning and control are to optimize capacity utilization, maintain optimal inventory levels, minimize costs, and ensure quality. Production planning involves determining what to produce, when, how much, and other long-term decisions. Production control techniques are used to achieve production planning targets by regulating inventory, scheduling production, and optimizing resource usage.
Industrial Engineering unit 4.Production planning and control Notes by badebhau.Er. Bade Bhausaheb
Production planning and control aims to efficiently and effectively manage operations in a manufacturing organization. It addresses issues like low productivity, inventory management, and resource utilization. The key objectives of production planning and control are to optimize capacity utilization, maintain optimal inventory levels, minimize costs, and ensure quality. Production planning involves determining what to produce, when, how much, and other long-term decisions. Production control techniques are used to achieve production planning targets by regulating inventory, scheduling production, and optimizing resource usage.
This document discusses in silico modeling techniques for predicting drug absorption and pharmacokinetic properties. It covers two main modeling approaches: quantitative approaches like pharmacophore modeling and QSAR which use statistical analysis of molecular descriptors to correlate structure to properties, and qualitative approaches. Specific techniques covered include modeling solubility, intestinal permeability, and factors like transporters and ionization state that influence absorption. The goal is to use these computational models to predict absorption and other pharmacokinetic properties early in drug discovery to improve candidate selection and reduce late-stage clinical failures.
The document discusses concepts, events, and biological processes involved in drug targeting. It defines drug targeting as selectively delivering pharmacologically active drugs to identified targets in therapeutic concentrations while restricting access to non-targets to minimize toxicity. It describes various strategies for drug targeting including chemical modifications, carrier-mediated delivery, and active targeting. It also outlines biological processes involved like cellular uptake, transport across epithelial barriers, extravasation into tissues, and lymphatic uptake that influence drug distribution. The presentation emphasizes how targeted delivery can improve efficacy and safety of drug therapy especially for cancer.
COMPUTER SIMULATIONS IN PHARMACOKINETICS & PHARMACODYNAMICSsagartrivedi14
Computer simulations in pharmacokinetics and pharmacodynamics can model the whole organism, isolated tissues, and individual organs. Whole organism simulations use lumped-parameter models that represent the body with a small number of differential equations, or physiological models that use more differential equations to describe organs in detail. Isolated tissue and organ simulations often use distributed blood tissue exchange models for organs like the heart and liver. These simulations aim to integrate organ-specific models with whole-body models to improve predictive capabilities in areas like pharmacokinetics.
Computational modeling in drug dispositionHimal Barakoti
The document discusses computational modeling of drug disposition. It covers modeling of drug absorption, distribution, excretion, and active transport. For drug absorption, it describes modeling of solubility, intestinal permeability, and transporters involved. It also discusses modeling approaches for distribution processes like volume of distribution, plasma protein binding, and blood-brain barrier permeability. Current challenges include better incorporating the effects of active transporters in models. The document emphasizes that while computational models are useful for predicting drug properties, fully accounting for complex biological factors remains difficult.
Computer simulations in pharmacokinetics and pharmacodynamicsGOKULAKRISHNAN S
This document discusses computer simulations in pharmacokinetics and pharmacodynamics. It describes how whole organism, isolated tissue, and organ simulations work. For whole organism simulations, two approaches are used: lumped-parameter PK-PD modeling which uses differential equations to model the system over time, and physiological modeling which attempts to model interacting organs in detail. Isolated tissue and organ simulations are also discussed, focusing on models of the heart, liver, kidney and brain. The challenges of complexity and model selection are addressed.
Computerized marketing can facilitate more efficient collection and dissemination of current market information compared to traditional phone-based methods. It could potentially eliminate 90% of the costs associated with negotiating sales. It may also increase competition by allowing traders to more easily communicate with each other. Previous computerized marketing systems have resulted in higher prices for growers, from both increased competition and improved operational efficiency, with cost savings being passed on to growers. A survey of industry participants found general support for developing a computerized marketing system to complement existing practices.
The document discusses various drug delivery systems including niosomes, aquasomes, and phytosomes. Niosomes are vesicles composed of non-ionic surfactants that can encapsulate medications and offer advantages over liposomes such as lower cost and greater stability. Aquasomes are three-layered nanoparticle structures consisting of a ceramic core coated with an oligosaccharide film that can deliver fragile molecules while maintaining their integrity. Phytosomes utilize phospholipids to surround active herbal constituents, improving their absorption and bioavailability compared to traditional herbal extracts.
Tumour targeting and Brain specific drug deliverySHUBHAMGWAGH
The document discusses tumor targeting and brain specific drug delivery. It provides an introduction to targeted drug delivery and outlines strategies for tumor targeting including passive targeting via the enhanced permeability and retention effect, active targeting using ligands, and triggered drug delivery responsive to microenvironment changes. It also discusses challenges of drug delivery to the brain posed by the blood-brain barrier and factors that affect crossing it, as well as diseases related to the brain and strategies to enhance brain-specific drug delivery.
The document discusses several key concepts related to drug transport and absorption:
1) The pH partition hypothesis states that acidic drugs are absorbed from acidic solutions and basic drugs from alkaline solutions, though some exceptions exist due to the microclimate pH near the membrane surface.
2) Tight junctions form a virtually impermeable barrier between cells, composed of sealing strands that prevent fluid passage.
3) According to Fick's first law, passive diffusion of solutes is determined by concentration gradients and membrane permeability. For ionizable drugs, the uncharged form is more permeable. The pH partition hypothesis relates permeability to pH and the fraction of uncharged molecules.
Computational modelling of drug disposition lalitajoshi9
computational modelling of drug disposition is the integral part of computer aided drug design. different kinds of tools being used in the prediction of drug disposition in human body. This topic in the CADD explains the details about the drug disposition, active transporters and tools.
The document describes electrosomes, which are lipid vesicles containing ion channel proteins that allow ion transport. Electrosomes consist of two compartments - an anode displaying enzymes for ethanol oxidation and a cathode displaying an oxygen-reducing enzyme. Enzymes containing dockerin modules are attached to cohesin sites on scaffoldin proteins and displayed on yeast cell surfaces. This allows electron transfer through enzymatic cascades for high fuel cell power output. Electrosomes show potential as drug delivery carriers by controlling drug release and targeting tissues selectively.
computer simulation in pharmacokinetics and pharmacodynamicsSUJITHA MARY
This document discusses the use of computer simulation in pharmacokinetics and pharmacodynamics at four different levels: whole organism, isolated tissues/organs, cellular, and protein/gene levels. At each level, mathematical models are used to represent biological processes and predict behavior over time. The goal is to better understand drug behavior and improve drug development by replacing animal and human trials with computer simulations. Challenges include integrating data from different structural levels and ensuring high quality input data.
This document summarizes ICH Q8 guidelines for pharmaceutical product development. It discusses key aspects of quality by design (QbD) like quality target product profiles, critical quality attributes, and critical process parameters. The document also outlines the contents recommended for the quality module in a common technical document, including drug substances, excipients, formulation development, manufacturing processes, containers and closures, microbiological attributes, and compatibility studies. The goal of QbD and ICH Q8 is to build quality into pharmaceutical products through scientific approaches and risk management during development.
Artificial intelligence robotics and computational fluid dynamics Chandrakant Kharude
The document discusses applications of artificial intelligence, robotics, and computational fluid dynamics in the pharmaceutical industry. It provides introductions and definitions for each technology, as well as their current and potential applications. Some key applications discussed include using AI for disease identification, personalized treatment, drug discovery/manufacturing, and clinical trials. Applications of robotics mentioned include use in research and development, packaging, sterile syringe filling, and laboratory automation. Current challenges and future directions are also addressed.
Computational modeling of drug dispositionPV. Viji
Computational modeling of drug disposition , Modeling techniques , Drug absorption , solubility , intestinal permeation , Drug distribution , Drug excretion , Active Transport , P-gp , BCRP , Nucleoside transporters , hPEPT1 , ASBT , OCT , OATP , BBB-choline transporter
This document discusses various compendial methods for drug dissolution testing. It begins by defining dissolution as the process where a solid substance solubilizes in a solvent, transferring mass from the solid surface to the liquid phase. It then describes the seven USP dissolution apparatus types and their applications for testing different drug products like tablets, capsules, modified release formulations and transdermal systems. The document provides details on factors that influence dissolution test design and the principles of operation for each apparatus type.
This document discusses computer aided formulation development and optimization techniques. It covers topics like optimization parameters, response surface curves, experimental designs, and factorial designs. Specifically, it defines optimization as making a design or system as effective as possible. It also describes types of experimental designs like factorial designs, which study the effects of varying multiple factors simultaneously. Full and fractional factorial designs are explained, with fractional designs requiring fewer runs by testing only a subset of the full factorial design combinations.
Industrial Engineering unit 4.Production planning and control Notes by badebhau.Er. Bade Bhausaheb
Production planning and control aims to efficiently and effectively manage operations in a manufacturing organization. It addresses issues like low productivity, inventory management, and resource utilization. The key objectives of production planning and control are to optimize capacity utilization, maintain optimal inventory levels, minimize costs, and ensure quality. Production planning involves determining what to produce, when, how much, and other long-term decisions. Production control techniques are used to achieve production planning targets by regulating inventory, scheduling production, and optimizing resource usage.
Industrial Engineering unit 4.Production planning and control Notes by badebhau.Er. Bade Bhausaheb
Production planning and control aims to efficiently and effectively manage operations in a manufacturing organization. It addresses issues like low productivity, inventory management, and resource utilization. The key objectives of production planning and control are to optimize capacity utilization, maintain optimal inventory levels, minimize costs, and ensure quality. Production planning involves determining what to produce, when, how much, and other long-term decisions. Production control techniques are used to achieve production planning targets by regulating inventory, scheduling production, and optimizing resource usage.
Introduction, Objective; Significance; General consideration; Pilot plant scale up technique for solid, liquid and semi solids; SUPAC Guidelies; Introduction to platform technology
Introduction, Objective; Significance; General consideration; Pilot plant scale up technique for solid, liquid and semi solids; SUPAC Guidelies; Introduction to platform technology
This document provides an overview of operations management concepts related to forecasting, materials flow, production processes, and just-in-time systems. Specifically, it discusses forecasting methods and applications, defines materials flow and material flow management, describes different production systems including job shop, batch, and continuous production, and outlines the objectives, types of waste, tactics, and benefits of just-in-time systems.
Pilot plant scale-up is a branch of the pharma companies in which a lab-scale formula is converted into a commercially viable product by creating a reliable manufacturing technique. The same techniques employed in dosage form Research and Development are adapted to multiple output volumes, frequently larger than those obtained during Research and Development. There is always a requirement for an intermediate batch scale describing techniques and imitating those in commercial manufacturing in any new or established pharmaceutical sector. This is accomplished by testing the formula’s ability to survive batch-scale and process changes.
This document provides an overview of operations management concepts related to forecasting, materials flow, production processes, and just-in-time systems. Specifically, it discusses forecasting methods and applications, defines materials flow and material flow management, describes different production systems including job shop, batch, and continuous production, and outlines the objectives, types of waste, tactics, and benefits of just-in-time systems.
Pilot plant scale-up is a branch of the pharma companies in which a lab-scale formula is converted into a commercially viable product by creating a reliable manufacturing technique. The same techniques employed in dosage form Research and Development are adapted to multiple output volumes, frequently larger than those obtained during Research and Development. There is always a requirement for an intermediate batch scale describing techniques and imitating those in commercial manufacturing in any new or established pharmaceutical sector. This is accomplished by testing the formula’s ability to survive batch-scale and process changes.
This document discusses the space requirements and considerations for designing a pharmaceutical pilot plant facility. It outlines that the facility should have separate areas for administration, physical testing, standard equipment, and storage. The standard equipment area should contain portable intermediate and full-scale production equipment for evaluating scale-up effects. The document also discusses raw material approval and validation, master batch records, analytical method transfer, product stability testing, and GMP compliance considerations like equipment qualification and validation.
This document discusses the space requirements and considerations for designing a pharmaceutical pilot plant facility. It outlines that the facility should have separate areas for administration, physical testing, standard equipment, and storage. The standard equipment area should contain portable intermediate and full-scale production equipment for evaluating scale-up effects. The document also discusses raw material approval and validation, master batch records, analytical method transfer, product stability testing, and GMP compliance considerations like equipment qualification and validation.
pilot plant is a small system which is operated to find out about the behavior of a process before using it on a large industrial scale. so, this presentation tries to illustrate its objective and significance to understand the methodologies of various pharmaceutical dosage forms.
pilot plant is a small system which is operated to find out about the behavior of a process before using it on a large industrial scale. so, this presentation tries to illustrate its objective and significance to understand the methodologies of various pharmaceutical dosage forms.
Overview on History of computers in pharmaceutical research an.docxDrx.Urvashi Saini
A depiction of early pharmaceutical research without computer scientists using manual methods for data analysis.
Here is an overview providing you the history of computer in pharmaceutical research and development from past to current trends.
Medical Research is also known as biomedical research is the scientific process of studying human disease. It is divided into two parts.
Primary Research and Secondary Research.
In this SlideShare you find out what is the medical Research and it's types also with its basic principles made by World Medical Association(WMA) in the Doh. And also additional principles of medical Research with medical care.
Novel Drug delivery System (NDDS) refers to the approaches,
formulations, technologies, and systems for transporting a
pharmaceutical compound in the body as needed to safely
achieve its desired therapeutic effects.
This story board give details from ancient time to 21st century.
Microspheres are small spherical particles, with diameter 1-1000 micrometre. This presentation will give you knowledge about it's types it's applications, advantages, dis-advantages, method of preparation and it's evaluation parameters.
Acne vulgaris is a common skin condition that occurs when hair follicles become blocked with dead skin cells, and by anaerobic bacteria.
Go through this SlideShare and able to know more about Acne, it's causes and types, lifecycle, prevention .
Also find recent trends and therapies with new discoveries and it's statistics.
Form B (per rule 8(a)*for Submission of Research ProtocolDrx.Urvashi Saini
This document contains an application for permission of animal experiments and the research protocol to be submitted to the Institutional Animal Ethics Committee (IAEC) and the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).
The application includes details of the establishment, registration information, animals to be used, location of experiment, and signatures. The research protocol requests information on the project title, investigators, animals required, procedures, potential use of hazardous agents, and post-experiment plans. It requires the investigator's declaration and certification that alternatives to painful procedures were reviewed and approvals will be obtained.
The document discusses copyright information for a book published by NewAge International (P) Ltd., including the copyright years, a dedication to the author's father, intentionally blank pages, and a preface for the second edition noting feedback received and enhancements made.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
Beyond Degrees - Empowering the Workforce in the Context of Skills-First.pptxEduSkills OECD
Iván Bornacelly, Policy Analyst at the OECD Centre for Skills, OECD, presents at the webinar 'Tackling job market gaps with a skills-first approach' on 12 June 2024
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Pharmaceutical Automation,Computer aided drug development.pptx
1. PRESENTED TO PRESENTED BY
Dr.Anjali Sharma Urvashi Saini
(Associate Proff. ) M.pharma(M-410)
GURU GOBIND SINGH COLLEGE OF PHARMACY
YAMUNA NAGAR
2. Pharmaceutical Automation is considered to be a technology for
designing, analyzing, and controlling manufacturing through
timely measurements (i.e., during processing) of critical quality
and performance attributes of raw and in-process materials.
Automation-
Means the use of machines and the equipment for the performing
physical and mental operation in a production processing place
of human being.
It is a system of doing work where material handling, production
process and product design are integrated through mechanism of
thoughts and effort to achieve a set regulating and control
system.
3. It is the result of industrialization, driven by the need to
increase productivity and to archive consisting quality
product and processes with the goal of ensuring final
product quality.
It can be done various levels of manufacturing system
1. Handling of raw materials , semi-finished goods and
finished goods
2. During the production process(efficient machine are used)
3. In inspection and quality control operation
Purpose of Automation
1. To increase productivity
2. Reliving from heavy work load
3. Improve quality of products and reduce waste
4. For safe handling of hazardous substances
5. To reduce the cost
4. 1. It provides better quality of goods and service.
2. It minimizes the total cost ,in direct labor cost.
3. It provides effective control in operation.
4. Greater accuracy, more output and greater speed are
induced.
5. It can improve a better working condition.
6. Safety of workers is improved.
7. Minimal of wastage is done.
8. The quality of product improves as human input is
minimized.
5. 1. Huge capital investment is required.
2. The maintenance cost is very high because
maintenance labor of high caliber is required.
3. It can create unemployment.
4. Continuous power supply is required.
5. Large inventories are required
6. Any breakdown, anywhere lead to the complete
breakdown.
7. There are restrictions in designing and construction of
the building.
6. Benefits of automation in tablet production
1. Improve material handling.
2. Improve specific unit operation-Unit operations in tablet manufacturing:-
Particle size reduction
Sieving
Mixing
Particle size enlargement
Drying
Compression
Sorting
Coating
Packaging.
3.Eliminate or combine processing steps.
4. Incorporate automated process control of unit operation and processes.
7. Pharmaceutical packaging
Pharmaceutical packaging is the combination of
components necessary to contain, preserve, protect and
deliver a safe, efficacious drug product.
Functionally the packaging of pharmaceuticals involves
containment as well as protection from damaging
environmental factors such as moisture, oxygen,
temperature and light
In packaging system automation should include bottle
orientation, capping, labeling and collation.
Automation of packaging will also require a system for
monitoring the operation that will cover a no of
supervisory function, e.g. checking for low hopper level,
fallen bottles, low-level supply and its routine function.
8. New Types of Equipment And Technologies In Automation Of Packaging
Systems.
Bar code tracking
Robotics
Machine vision
Laser printing
9. 1. Internal packaging machine control only( no integration)
2. Electrical interlocking of packaging machine
3. Packaging equipment performance monitoring
4. Product to package verification
5. Machine readable code / text to product/package
verification
6. Manufacturing work order input from MEC or ERP
Automation in laboratory procedures
Analytical procedures can be divided into three stages-
1. Sample preparation
2. Qualitative or quantitative measurement
3. Data reduction