LO49 Explain how expression of related genes can be coordinated in eukaryotes. Which of the following examples can lead to coordinated transcription of genes in eukaryotes: The chromatin is loosely coiled around 3 genes A mediator is activated by a molecule from the environment A transcription factor binds to 3 different promoters when it is active The chromatin is tightly coiled around 3 genes An insulator blocks the expression of a gene that is downstream from an enhancer but not the one that is upstream.