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A,B,C,Z DNA

A ,B,C,Z DNA

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A,B,C,Z DNA

  1. 1. Sasna.p.s
  2. 2.  1.RIGHT HANDED DOUBLE HELIX WITH SHORTER AND MORE COMPACT HELICAL STRUCTURE[wider and less flexible].  2.CONDITION: 75% OF RELATIVE HUMIDITY & na+,k+,cs+ ions.  3. WHEN THE PUCKERING OF THE RIBOSE UNIT CONCERNED C3 IS OUT OF THE PLANE SO IT IS C3 ENDOPUCKERING
  3. 3.  4. HELIX DIAMETER :25.5 A*  5.RISE PER BASE PAIR :2.3A*  6.BASE PAIRS PER TURN OF HELIX :11  7:HELICAL PITCH :25.30A*  8.A DNA IS WIDER,LESS FLEXIBLE THAN B DNA IT CAN INCORPORATE MORE BASE PAIRS PER HELICAL TURN  9.PRESENCE OF MAJOR AND MINOR GROOVES.BUT SLIGHT INCREASE IN THE NUMBER OF BASE PAIR;RESULTING TIGHTER ROTATION ANGLE.AND SMALL RISE PER TURN.SO MAJOR GROOVE IS NARROW AND VERY DEEP. MINOR GROOVE IS VERY BROAD AND SHALLOW
  4. 4.  1.THE TWO CHAIN IN THE DOUBLE HELIX ARE ANTIPARALLEL [ones goes 5’-3’ where as complementary strand goes 3’-5’]  2.THE BASES ON THE 2 CHAINS PAIR IN A COMPLEMENTARY FASHION ADENINE [A] PAIR WITH THYMINE [T]. GUANINE[G] PAIR WITH CYTOSINE[C]  3.PHOSPHATE GROUPS ARE LINKED TOGETHER THE SUGAR BACKBONE HAVE PHOPHODIESTER BONDS
  5. 5. 4. HYDROGEN BONDS BETWEEN BASES [3 FOR G-C, 2 FOR A-T] HOLD HELIX TOGETHER 5. THERE ARE 10 BASE PER TURN OF THE HELIX SO THE HELIX ROTATES 36 DEGREE PER BASE 6. THE RISE OF DOUBLE HELIX IS THE DISTANCE PARELLEL TO THE AXIS OF THE HELIX FROM THE LEVEL OF ONE BASE TO THE LEVEL OF ADJACENT BASE
  6. 6.  7.THE PITCH IN B- DNA IS 3.4 nm BECAUSE THE RISE IS 0.34 nm AND THERE ARE 10 BASE PAIRS PER TURN OF HELIX  8.B-DNA IS FORMED AT THE RELATIVE HUMIDITY 92% IN THE PRESENCE OF LOW ION STRENGTH  9.B-DNA POSSES MAJOR AND MINOR GROOVES
  7. 7.  1.C-DNA IS FORMED AT THE RELATIVE HUMIDITY 66% IN THE PRESENCE OF Li+ IONS  2.RIGHT HANDED WITH AN AXIAL RISE OF 3.32A*  3.9.33 BASE PAIRS PER TURNS OF THE HELIX  4.HELIX PITCH IS 30.97A*
  8. 8.  5.THE ROTATIONS PER BASE PAIR IS 38.58 DEGREE  6.HELIX DIAMETER IS 19A*  7.MAJOR AND MINOR GROOVE IS ABSENT
  9. 9.  1.LEFT HANDED HELICAL ROTATION [RICH,NORDHIEM AND WANG IN 1984]  2.HEXA NUCLEOTIDE  3.CGCGCG FORMS THE DUPLEX OF ANTIPARRELLEL STRAND  4.THE PHOSPHATES IN THE Z DNA BACKBONE IS ZIG-ZAG MANNER HENCE THEY TERMED AS Z-DNA
  10. 10. 5. ADJACENT SUGAR RESIDUE HAVE ALTERNATING ORIENTATION [REPEATING UNIT IS A DINUCLEOTIDE] 6.Z-DNA HAVE ONLY ONE DEEP HELICAL GROOVE 7.Z-DNA INVOLVED IN REGULATION OF GENE EXPRESSION,GENETIC RECOMBINATION,
  11. 11. 8.Z-DNA SERVE AS A RECOGANITION SIGNALS IN THE REGULATION OF GENETIC TRANSCRIPTION AND DNA REPLICATION.IT ALSO PLAY A ROLE IN GENE CONVERSION AND GENETIC INSTABILITY 9.Z-DNA IS FORMED AT VERY HIGH SALTCONCENTRATION
  12. 12. CHARACTERISTIC A-DNA B-DNA C-DNA Z-DNA CONDITIONS 75% OF RELATIVE HUMIDITY;K+ Na+,Cs+ IONS 92% RELATIVE HUMIDITY ;LOW ION STRENGTH 60% RELATIVE HUMIDITY ;Li+ IONS VERY HIGH SALT CONCENTRATI- ON SHAPE BROADEST INTER MEDIATE NARROW NARROWEST HELIX SENSE RIGHT HANDED RIGHT HANDED RIGHT HANDED LEFT HANDED HELIX DIAMETER 25.5 A* 23.7 A* 19.0 A* 18.4 A* RISE PER BASE PAIR(h) 2.3 A* 3.4 A* 3.32 A* 3.8 A* BASE PAIRS PER TURN OF HELIX(n) 11 10.4 9.33 12(=6 DIMER) HELIX PITCH(hXn) 25.30 A* 35.36 A* 30.97 A* 45.60 A*
  13. 13. CHARACTERISTICS A DNA B DNA C DNA Z DNA ROTATION PER BASE PAIR +32.72 +34.61 +38.58 -60(PER DIMER) BASE PAIR PER TILT 19 DEGREE 1 DEGREE _ 9 DEGREE GLYCOSIDIC BOND ANTI ANTI _ ANTI FOR C-T SYN FOR A-G MAJOR GROOVE NARROW AND VERY DEEP WIDE AND QUITE DEEP _ FLAT MINOR GROOVE VERY BROAD AND SHALLOW NARROW AND QUITE DEEP _ VERY NARROW AND DEEP

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