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Neonatal sepsis
1. DR. V. VEERA RATNAKAR REDDY
Senior resident.
05/08/14 Fr. Muller Medical College, Kankanady. 1
2. What is meant by sepsis ??
Systemic bacterial infections are known by the
generic term neonatal sepsis.
05/08/14 Fr. Muller Medical College, Kankanady. 2
3. Definition
Neonatal sepsis is a clinical syndrome
characterized by signs and symptoms of
infection with or without accompanying
bacteremia in the first month of life.
Incorporates septicemia, pneumonia, and meningitis
of the newborn.
Incidence approximately 30/1000 live births
05/08/14 Fr. Muller Medical College, Kankanady. 3
4. Etiology
E.Coli, Staph aureus, Group B Streptococcus and
Klebsiella sp. Are responsible for most cases.
MC CAUSE OF CONG PNEUMONIA-?
As per aiims study both extramural and intramural
cause of sepsis is in the order of: Klebsiella>
s.aureus>e. coli.
05/08/14 Fr. Muller Medical College, Kankanady. 4
5. EARLY ONSET LATE ONSET
ONSET <72 hrs >72 hrs
SOURCE Maternal Nursery
Organism Gp B Strept, E.
Coli
Gram –ve, Staph
Aureus
Maternal Risk
Factors
Present Absent
Presentation Multisystem,
Pneumonia
Focal, Meningitis
Course Fatal Recovery
05/08/14 Fr. Muller Medical College, Kankanady. 5
Types: EOS, LOS, VLOS
7. Infant born through foul smelling liquor/
3 of risk factors/
1 major+2 minor
require treatment with Abs
with 2 risk factors= needs to be investigated
05/08/14 Fr. Muller Medical College, Kankanady. 7
25. Duration of AB COURSE:
Meningitis (with or without positive blood/CSF
culture) : 21
Blood culture positive but no meningitis:14
Culture negative, sepsis screen positive and
clinicalcourse consistent with sepsis: 7-10
Culture and sepsis screen negative, but clinical
coursecompatible with sepsis: 5-7
Arthritis, endocarditis, osteomyelitis: 4 -6w
Ventriculitis: 6wk
05/08/14 Fr. Muller Medical College, Kankanady. 25
27. Summary
Systemic infections in newborn is known as neonatal
sepsis.
Clinical symptomatology is vague and non-specific
Mortality is high among LBW babies and gram
negative sepsis.
Combination of Cefotaxim and Amikacin found to be
a better combination.
05/08/14 Fr. Muller Medical College, Kankanady. 27