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An Introduction to Danish Life Science
          - and Medicon Valley

        Bangalore INDIA BIO 2011
AGENDA

                 BIOTECH IN
                  DENMARK

                 MEDICON
                  VALLEY


3 August, 2011
Denmark & Medicon valley




3 August, 2011
BIOTECH IN
                                                                DENMARK


    The Danish Life Sciences Cluster - facts
-    7 science parks                    -   25 CROs

-    8 universities                     -   ≥ 160 core biotech

-    75 hospitals (4 major university       companies

     hospitals)                         -   ≥ 180 core medtech

-    10,000 life science graduates          companies

     annually                           -   48,000 employees in the life

-    2,000 LS PhDs students                 science industry

     graduating annually
BIOTECH IN
                                                      DENMARK


      DENMARK COMPARES WELL
      and it is not just something we say...
• Denmark is among the five countries in the world (and 2nd
  in Europe) with the most likely potential for development
  of biotechnology
    (Scientific American 2010)





• The 3rd best overall biotech sector in the world
    (fDi Magazine, 2008)



• Stable funding situation in the middle of a financial storm
    (Ernst and Young 2010)



• The 3rd largest commercial drug development pipeline in
  Europe (in actual numbers)
    (Ernst and Young 2010)
BIOTECH IN
                                                                                       DENMARK


             Denmark – European TOP 3 position (pipeline)




                               Preclinical:             Phase I:        Phase II:   Phase III:
        Research
                                    69                    59             58           40
(Total commercial drug development pipeline in Denmark Source: Invest
in Denmark, 2010; Copenhagen Capacity 2010)




                   6   Source: Ernst & Young, Beyond borders 2010
BIOTECH IN
                                                                                                                                                                                                     DENMARK



THE POOL OF BIOTECH´S KEEPS GROWING
                                                 New Biotech Start-ups in Denmark
                   20

                   18

                   16

                   14
 Antal start-ups




                   12

                   10

                   8

                   6

                   4

                   2

                   0
                                                                                                 1996

                                                                                                         1997

                                                                                                                1998

                                                                                                                       1999

                                                                                                                              2000

                                                                                                                                     2001

                                                                                                                                            2002

                                                                                                                                                   2003

                                                                                                                                                          2004

                                                                                                                                                                 2005

                                                                                                                                                                        2006

                                                                                                                                                                               2007

                                                                                                                                                                                      2008

                                                                                                                                                                                             2009
                                     1925-1950

                                                 1951-1975

                                                             1976-1985

                                                                         1986-1990

                                                                                     1991-1995
                        until 1925




                                     7                                                                  Source: Danish Biotech Ass., December 2009
BIOTECH IN
                                                                                                                                                                                       DENMARK

TOTAL NUMBER OF BIOTECH COMPANIES IN DENMARK
                       180

                       160

                       140

                       120
  Antal virksomheder




                       100

                        80

                        60

                        40

                        20

                        0
                             Indtil…

                                       1988

                                              1989

                                                     1990

                                                            1991

                                                                   1992

                                                                          1993

                                                                                 1994

                                                                                        1995

                                                                                               1996

                                                                                                      1997

                                                                                                             1998

                                                                                                                    1999

                                                                                                                           2000

                                                                                                                                  2001

                                                                                                                                         2002

                                                                                                                                                2003

                                                                                                                                                       2004

                                                                                                                                                              2005

                                                                                                                                                                     2006

                                                                                                                                                                            2007

                                                                                                                                                                                   2008

                                                                                                                                                                                          2009
                                         8                                        Source: Danish Biotech Ass., December 2009
BIOTECH IN
                                                                               DENMARK
                       Denmark is among the largest exporters per capita of
                                    pharmaceutical products
                            Development in Danish drug exports 1997-2010:
              60

              50

              40
Billion DKK




              30

              20

              10

              0
                   1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
INVEST IN
                                                         DENMARK

 THE DANISH LIFE SCIENCE CLUSTER HOLDS AREAS OF
    GLOBAL BUSINESS EXCELLENCE & STRONGHOLDS

    BIOTECH          MEDTECH                       ICT


     CANCER          DIAGNOSTICS


                       ASSITIVE
    METABOLIC
                     TECHNOLOGY


       CNS           DISPOSABLES


  INFLAMATORY &
INFECTION DISEASES


                                     ROBOTICS

                                   HEALTHCARE IT
BIOTECH IN
                                                                   DENMARK



    Danish competences – Biotech cluster

Areas of Business Excellences              Biotech strongholds
                                           (Technological platforms)
-   Cancer/oncology                         -   Biomedical Informatics

-   CNS/Neuroscience                        -   Clinical Trials
                                            -   Personalized Medicine
-   Metabolic diseases
                                            -   Proteomics

-   Inflammatory and Infectious diseases    -   Nanomedicine
                                            -   Drug Delivery
                                            -   Vaccines
BIOTECH IN
                                     DENMARK
Life Science centres in Denmark




                          Science Parks


                          Innovation Incubators


                          University Hospitals
7 Science Parks

           The Science Parks holds:

•   Incubator solutions
•   Access to VC’s- from pre-seed to seed
•   A facilitating and knowledge-sharing
    environment
•   Access to state-of-the-art lab facilities
•   Cost-competitive m2 prices
•   Usually located close to the universities
6 Innovation Incubators
The purpose of the innovation incubator scheme is to create and
develop more knowledge-intensive start-ups with unique skills

  Innovation incubators:

  •   seeks out and screen risky commercialization ideas
      invest in commercialization ideas
  •   ensure access to appropriate facilities for the knowledge-based
      entrepreneurship
  •   advise entrepreneurs on how to maturation the commercializing idea
  •   help entrepreneurs to build contacts with private investors to attracted
      capital
BIOTECH IN
                                      DENMARK



CLUSTERS IN DENMARK   Northern Jutland/Aalborg
                      • Biomedical technology

                      Central Jutland/Aarhus
                      • Biotech/Biomedical
                       technology/Food
                       innovation

                      Funen/Odense
                      • Biomedical technology

                      Copenhagen area
                      • Medicon Valley
MEDICON
                  VALLEY


MEDICON VALLEY
MEDICON
                                               VALLEY


   MEDICON VALLEY – one of Europe´s strongest life
   science clusters




1997                        2011
MEDICON
                                               VALLEY

MEDICON VALLEY – BASIC FACTS & FIGURES

Population: 3.5 mill.       44.000 life-science
7 large R&D based           employees in the private
pharma companies with       sector
local roots                 9 science parks
App.150 biotechs with       11 universities (5 supply
own R&D                     life science educations)
App. 200 medtech            155.000 students (app
companies                   1/3 in Life Sciences)
More than 50 CROs and       More than a dozen VCs
CMOs                        with experienced life
33 hospitals (of which 11   science teams
are university hospitals)
     18
MEDICON
                                        VALLEY


MEDICON VALLEY STRONGHOLDS

• Global leadership in diabetes and
  obesity
• World-class R&D in CNS
• Very strong R&D tradition in other
  important therapeutic areas, e.g.
  inflammation, infectious diseases,
  immunology and oncology
• Emerging position in the field of
  personalized medicine
MEDICON
                                            VALLEY


MEDICON VALLEY – where tradition meets the future


Tradition: Novo Nordisk, LEO
Pharma, Lundbeck, Nycomed,
Ferring, ALK Albello

Stars of the future: Bavarian
Nordic, Neurosearch, Zealand
Pharma, Genmab, Santaris
Pharma, Symphogen, Lifecycle
Pharma, Action Pharma, Exiqon
BIOTECH IN
                                                               DENMARK



Danish headline deal makers (selected examples)
•   Topotarget and Spectrum Pharmaceuticals (2010)
•   Genmab : GSK (2006) and TenX (2010)
•   LEO : Buy-back of US psoriasis portfolio from Warner-Chilcott (2009)
•   LEO : Acquisition of Peplin (AU) for USD 287.5 mill. (2009)
•   Santaris: Enzon (2006), GSK (2007), Wyeth (2009) and Shire (2009)
•   Neurosearch: Abbot (1999), GSK (2003) and Eli Lilly (2009), Janssen
    (2009)
•   Symphogen: Meiji Seika (2006), Genentech (2008), Origen (2009)
•   Upfront Chromatography and Cangene (2009)
•   Egalet and RedHill Biopharma (2009)
•   Nuevolution: Merck(2008)
•   Lundbeck: Ovation acquisition (2008)
•   Zealand: Sanofi-Aventis (2003) and Helsinn (2008)
•   Zymenex : Divestment of Metazym to Shire (2008)
•   Exiqon: OncoTech acquisition (2007)
•   Lifecycle : Mylan (2006), Sandoz (2006) and Sciele (2007)
www.mediconvalley.com
BIOTECH IN
                                                         DENMARK



Business Solutions


Choose DK for your next R&D Center

 Choose DK for your SalesMarketing office

 Choose DK for Biopharmaceutical Production

 Choose DK for your North European HQ

 The Best Environment for conducting Clinical Trials
BIOTECH IN
                                                        DENMARK



Denmark’s best business framework
• Flexicurity – easy hire and lay off practices

• Best labour relations in the world

• Human resources - World’s most motivated and best trained
  labour force

• Flexible and cooperative government – no red tape

• 2nd most stable political environment in the world

• 25% corporate tax

• 3rd best infrastructure in the world

• Economic top performer
BIOTECH IN
                                                           DENMARK


Assistance from INVEST IN DENMARK


• Identification of specific business opportunities
   Potential partners

• Comprehensive fact base and decision-making support
   Taxation, employment laws, regulatory issues

• Local contacts
  IP consultants, lawyers, authorities & public/private
  co-operation partners

• Tools – unique benchmark, cost/benefit & logistic tools
For more information , Pls contact below :


                                          PRAMILA DAS , MSc, MBA
                                          Investment Manager, LifeSciences




                                INVEST IN DENMARK– INDIA OFFICE
                                M +91 99456 96801
                                DIR: 91 80 4157 0057
                                EMAIL PRADAS@UM.DK

                                TRADE COMMISSION OF DENMARK
                                142, 4th Main Road, Defence Colony
                                Indiranagar, BANGALORE - 560 038
                                Tel: +91 (80) 4157 0057
                                WWW.INVESTINDK.COM

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Medicon Valley and Life science cluster in Denmark

  • 1. An Introduction to Danish Life Science - and Medicon Valley Bangalore INDIA BIO 2011
  • 2. AGENDA BIOTECH IN DENMARK MEDICON VALLEY 3 August, 2011
  • 3. Denmark & Medicon valley 3 August, 2011
  • 4. BIOTECH IN DENMARK The Danish Life Sciences Cluster - facts - 7 science parks - 25 CROs - 8 universities - ≥ 160 core biotech - 75 hospitals (4 major university companies hospitals) - ≥ 180 core medtech - 10,000 life science graduates companies annually - 48,000 employees in the life - 2,000 LS PhDs students science industry graduating annually
  • 5. BIOTECH IN DENMARK DENMARK COMPARES WELL and it is not just something we say... • Denmark is among the five countries in the world (and 2nd in Europe) with the most likely potential for development of biotechnology (Scientific American 2010)  • The 3rd best overall biotech sector in the world (fDi Magazine, 2008) • Stable funding situation in the middle of a financial storm (Ernst and Young 2010) • The 3rd largest commercial drug development pipeline in Europe (in actual numbers) (Ernst and Young 2010)
  • 6. BIOTECH IN DENMARK Denmark – European TOP 3 position (pipeline) Preclinical: Phase I: Phase II: Phase III: Research 69 59 58 40 (Total commercial drug development pipeline in Denmark Source: Invest in Denmark, 2010; Copenhagen Capacity 2010) 6 Source: Ernst & Young, Beyond borders 2010
  • 7. BIOTECH IN DENMARK THE POOL OF BIOTECH´S KEEPS GROWING New Biotech Start-ups in Denmark 20 18 16 14 Antal start-ups 12 10 8 6 4 2 0 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 1925-1950 1951-1975 1976-1985 1986-1990 1991-1995 until 1925 7 Source: Danish Biotech Ass., December 2009
  • 8. BIOTECH IN DENMARK TOTAL NUMBER OF BIOTECH COMPANIES IN DENMARK 180 160 140 120 Antal virksomheder 100 80 60 40 20 0 Indtil… 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 8 Source: Danish Biotech Ass., December 2009
  • 9. BIOTECH IN DENMARK Denmark is among the largest exporters per capita of pharmaceutical products Development in Danish drug exports 1997-2010: 60 50 40 Billion DKK 30 20 10 0 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
  • 10. INVEST IN DENMARK THE DANISH LIFE SCIENCE CLUSTER HOLDS AREAS OF GLOBAL BUSINESS EXCELLENCE & STRONGHOLDS BIOTECH MEDTECH ICT CANCER DIAGNOSTICS ASSITIVE METABOLIC TECHNOLOGY CNS DISPOSABLES INFLAMATORY & INFECTION DISEASES ROBOTICS HEALTHCARE IT
  • 11. BIOTECH IN DENMARK Danish competences – Biotech cluster Areas of Business Excellences Biotech strongholds (Technological platforms) - Cancer/oncology - Biomedical Informatics - CNS/Neuroscience - Clinical Trials - Personalized Medicine - Metabolic diseases - Proteomics - Inflammatory and Infectious diseases - Nanomedicine - Drug Delivery - Vaccines
  • 12. BIOTECH IN DENMARK Life Science centres in Denmark Science Parks Innovation Incubators University Hospitals
  • 13. 7 Science Parks The Science Parks holds: • Incubator solutions • Access to VC’s- from pre-seed to seed • A facilitating and knowledge-sharing environment • Access to state-of-the-art lab facilities • Cost-competitive m2 prices • Usually located close to the universities
  • 14. 6 Innovation Incubators The purpose of the innovation incubator scheme is to create and develop more knowledge-intensive start-ups with unique skills Innovation incubators: • seeks out and screen risky commercialization ideas invest in commercialization ideas • ensure access to appropriate facilities for the knowledge-based entrepreneurship • advise entrepreneurs on how to maturation the commercializing idea • help entrepreneurs to build contacts with private investors to attracted capital
  • 15. BIOTECH IN DENMARK CLUSTERS IN DENMARK Northern Jutland/Aalborg • Biomedical technology Central Jutland/Aarhus • Biotech/Biomedical technology/Food innovation Funen/Odense • Biomedical technology Copenhagen area • Medicon Valley
  • 16. MEDICON VALLEY MEDICON VALLEY
  • 17. MEDICON VALLEY MEDICON VALLEY – one of Europe´s strongest life science clusters 1997 2011
  • 18. MEDICON VALLEY MEDICON VALLEY – BASIC FACTS & FIGURES Population: 3.5 mill. 44.000 life-science 7 large R&D based employees in the private pharma companies with sector local roots 9 science parks App.150 biotechs with 11 universities (5 supply own R&D life science educations) App. 200 medtech 155.000 students (app companies 1/3 in Life Sciences) More than 50 CROs and More than a dozen VCs CMOs with experienced life 33 hospitals (of which 11 science teams are university hospitals) 18
  • 19. MEDICON VALLEY MEDICON VALLEY STRONGHOLDS • Global leadership in diabetes and obesity • World-class R&D in CNS • Very strong R&D tradition in other important therapeutic areas, e.g. inflammation, infectious diseases, immunology and oncology • Emerging position in the field of personalized medicine
  • 20. MEDICON VALLEY MEDICON VALLEY – where tradition meets the future Tradition: Novo Nordisk, LEO Pharma, Lundbeck, Nycomed, Ferring, ALK Albello Stars of the future: Bavarian Nordic, Neurosearch, Zealand Pharma, Genmab, Santaris Pharma, Symphogen, Lifecycle Pharma, Action Pharma, Exiqon
  • 21. BIOTECH IN DENMARK Danish headline deal makers (selected examples) • Topotarget and Spectrum Pharmaceuticals (2010) • Genmab : GSK (2006) and TenX (2010) • LEO : Buy-back of US psoriasis portfolio from Warner-Chilcott (2009) • LEO : Acquisition of Peplin (AU) for USD 287.5 mill. (2009) • Santaris: Enzon (2006), GSK (2007), Wyeth (2009) and Shire (2009) • Neurosearch: Abbot (1999), GSK (2003) and Eli Lilly (2009), Janssen (2009) • Symphogen: Meiji Seika (2006), Genentech (2008), Origen (2009) • Upfront Chromatography and Cangene (2009) • Egalet and RedHill Biopharma (2009) • Nuevolution: Merck(2008) • Lundbeck: Ovation acquisition (2008) • Zealand: Sanofi-Aventis (2003) and Helsinn (2008) • Zymenex : Divestment of Metazym to Shire (2008) • Exiqon: OncoTech acquisition (2007) • Lifecycle : Mylan (2006), Sandoz (2006) and Sciele (2007) www.mediconvalley.com
  • 22. BIOTECH IN DENMARK Business Solutions Choose DK for your next R&D Center  Choose DK for your SalesMarketing office  Choose DK for Biopharmaceutical Production  Choose DK for your North European HQ  The Best Environment for conducting Clinical Trials
  • 23. BIOTECH IN DENMARK Denmark’s best business framework • Flexicurity – easy hire and lay off practices • Best labour relations in the world • Human resources - World’s most motivated and best trained labour force • Flexible and cooperative government – no red tape • 2nd most stable political environment in the world • 25% corporate tax • 3rd best infrastructure in the world • Economic top performer
  • 24. BIOTECH IN DENMARK Assistance from INVEST IN DENMARK • Identification of specific business opportunities Potential partners • Comprehensive fact base and decision-making support Taxation, employment laws, regulatory issues • Local contacts IP consultants, lawyers, authorities & public/private co-operation partners • Tools – unique benchmark, cost/benefit & logistic tools
  • 25. For more information , Pls contact below : PRAMILA DAS , MSc, MBA Investment Manager, LifeSciences INVEST IN DENMARK– INDIA OFFICE M +91 99456 96801 DIR: 91 80 4157 0057 EMAIL PRADAS@UM.DK TRADE COMMISSION OF DENMARK 142, 4th Main Road, Defence Colony Indiranagar, BANGALORE - 560 038 Tel: +91 (80) 4157 0057 WWW.INVESTINDK.COM