Insulin

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Melissa Anne Lim

Presentation on basic information on insulin

PRoTein: Insulin Biology 185 PJ LeBLanc MeLissa Lim Sonny PaTeL DaN MiRau

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ABSTRACT- Introduction: Importance of measurement of glycated hemoglobin (HbA1c) has been recommended for the diagnosis of diabetes and pre-diabetes. However, various epidemiological studies conducted different parts of the universe have shown significant discordance between HbA1c and glucose-based tests. Glycated hemoglobin (HbA1c) is assumed to be the gold standard for monitoring glycemic control in patients with diabetes mellitus disorder. The Glycated hemoglobin (HbA1c) assay provided an accurate, precise measure of chronic glycemic levels, and associates with the risk of diabetes complications. Materials and Methods: This is a cross sectional prospective study. A total of 868 individuals attended to the medicine outpatient clinic at Lord Buddha Koshi Medical College, Saharsa, Bihar between Jan 2016 to Dec 2016 were selected for the study after screening a large cohort visited OPD. The results of FPG, OGTT, and HbA1c for 868 individual were analyzed as well as all grouped as diabetic patients, glucose intolerant (pre-diabetes) patients, and non-diabetic patients according to new ADA criteria for the diagnosis of diabetes. Results: Diagnostic sensitivity of all diabetic criteria were 80.33% for A1c; 75% for OGTT and only 41.87% for FPG respectively. Conclusion: The proposed A1c diagnostic criteria have greater diagnostic than FPG and 2-h OGTT regarding a diagnosis of diabetes mellitus disorder. Key-words- Glycated Hemoglobin, Fasting Plasma Glucose, Oral glucose tolerances test (OGTT), Diabetes Mellitus, and Pre- diabetes

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Software engineers share experiences with modern technologies by means of software information sites, such as Stack Overflow. These sites allow developers to label posted content, referred to as software objects, with short descriptions, known as tags. However, tags assigned to objects tend to be noisy and some objects are not well tagged. To improve the quality of tags in software information sites, we propose EnTagRec, an automatic tag recommender based on historical tag assignments to software objects and we evaluate its performance on four software information sites, StackOverflow, AskUbuntu, AskDifferent and FreeCode. We observe that that EnTagRec achieves Recall@5 scores of 0.805, 0.815, 0.88 and 0.64, and Recall@10 scores of 0.868, 0.876, 0.944 and 0.753, on StackOverflow, AskUbuntu, AskDifferent and FreeCode, respectively. In terms of Recall@5 and Recall@10, averaging across the 4 datasets, EnTagRec improves TagCombine, which is the state of the art approach, by 27.3\% and 12.9\% respectively.

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Pancreas is composed of two major types of tissues. 1. The Acini: which secrete digestive juices into the duodenum. 2. The islets of Langerhans: Contain three major types of cells INSULINMetabolized by the enzyme Insulinase (present mainly in the liver, kidneys and muscles). Insulin is a small protein, it is composed of two amino acid chains connected to each otherby disulfide linkages. When the two amino acid chainsare split apart, the functional activity of the insulinmolecule is lost. Insulin is synthesized in the beta cells. Diabetes Mellitus

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