Recent updates in synthetic polymers used in drug delivery systems

Recent updates in synthetic polymers used in drug delivery systems KUSUM SINGH NEELAM SINGH I.T.S. PHARMACY COLLEGE,GHAZIABAD, INDIA

CONTENTS ,[object Object],[object Object],[object Object],[object Object],[object Object]

INTRODUCTION ,[object Object],[object Object],[object Object]

DEFINITION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CLASSIFICATION OF SYNTHETIC POLYMERS ON THE BASIS OF STRUCTURE BRANCHED CHAIN POLYMERS EXAMPLES :- Low Density Polythene CROSS LINKED POLYMERS EXAMPLES:- Bakelite, MF Resin LINEAR POYMERS EXAMPLES :- PEG, Polyesters

CONTD… ON THE BASIS OF DEGRADABILITY OF POLYMERS BIODEGRADABLE POLYMERS NONBIODEGRADABLE POLYMERS ENVIRONMENT RESPONSIVE POLYMERS ELECTRICALLY & CHEMICALLY CONTROLLED POLYMERS THERMOSENSITIVE POLYMERS pH-SENSITIVE POLYMERS

SYNTHETIC POLYMER :- CLASS EXAMPLES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PLA, PGA, PHB PCL, PMA, POLYDIOXANONES POLYSEBACIC ACID, PTA POLYPHOSPHAZENES, POLYPHOSPHONATE POLYCYANOACRYLATES, POLYURETHENES, POLYORTHOESTERS B) NONBIODEGRADABLE CELLULOSE DERIVATIVE SILICONES ACRYLIC POLYMERS OTHERS CMC, EC, CA, CAP PDS, COLLOIDAL SILICA PMA, PMMA, PHEMA PVP, EVA. POLYOXAMER

ON THE BASIS OF MONOMERIC UNITS CONTD… HOMOPOLYMERS COPOLYMERS GRAFTED COPOLYMERS ALTERNATING COPOLYMERS BLOCK COPOLYMERS RANDOM COPOLYMERS

PROPERTIES & SELECTION OF POLYMERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PROPERTIES OF SYNTHETIC POLYMER THAT NEED TO BE CONSIDERD FOR APPLICATION OF POLYMERS TO DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMER APPLICABILITY Poly Amino Amine dendrimer ,[object Object],[object Object],[object Object],Poly aryl ether dendrimer To deliver Methotrexate

SYNTHETIC POLYMER USED IN MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLASS SYNTHETIC POLYMERS SURFACTANTS Polyoxyethylene, Polyoxyethylene-9-lauryl ether,Polyoxyethylene-20-cetyl ether THIOLATED POLYMERS Polycarbophil, Polyacrylic acid

BIOADHESIVE POLYMERS IN MUCOADHESIVE DRUG DELIVERY SYSTEMS BIOADHESIVE PROPERTIES CHARACTERISTICS Poly-hydroxyl Butyrate Poly(e-caprolactone) Polyorthoesters Polyphosphazenes Polycyanoacrylates Polyvinyl Acetate Polyethyleneoxide-b-propylene oxide Biodegradable Properties can be changed by chemical modification Surface eroding polymer Can be tailored with versatile side chain functioning Biodegradable Biocompatible Amphiphillic surfactant Biocompatible Matrix for DDS Cell encapsulation Sustained DDS, opthalmology To make films, Hydrogels in DDS Surgical adhesives, glues in DDS Gels & Blended membranes in DD & Immobilization Protein delivery

SYNTHETIC POLYMERS USED IN SUSTAINED RELEASE DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object]

SYNTHETIC POLYMER APPLICABILITY Poly(Monosteroyl Glycerol-co-succinate) For Sustained release of Theophylline/ Risperidone from microparticles in-vitro Polyvinyl Acetate For sustained release capsules of Nifedipine Eudragit RLPM, RSPM & HPMC Sustained release of theophylline

SYNTHETIC POLYMER BASED VECTORS IN GENE THERAPY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN OPTHALAMIC DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object],[object Object]

CONTD… SYNTHETIC POLYMERS APPLICABILITY Polyhydroxy ethyl - methacrylate Used to formulate liposomes loaded with Dimyristoyl phosphatidylcholine (DMPC). It is optically transparent & release drug for a period of 8 days. Poly (D,L-lactide) Biodegradable polymer used for sustained retinal delivery of Celecoxib to inhibit diabetes induced Retinal oxidative demage Polyanhydrides, Polyorthoesters For sustained release of 5-FU Poly (Ɛ-caprolactone) rod shaped implants Tolerated by retinal tissues & used to release corticosteroid triamcinolone acetide over 4 weeks

SYNTHETC POLYMERS USED IN TRANSDERMAL DRUG DELIVERY SYSTEM ,[object Object],[object Object],[object Object]

IN TDDS POLYMERS ACTS AS MATRIX FORMERS BACKING LAYERS RELEASE LINERS RATE –CONTROLING MEMBRANE PRESSURE- SENSITIVE ADHESIVES (PSAs)

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN HYDROGEL DRUG DELIVERY SYSTEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC BIODEGRADABLE POLYMER PROPERTIES & APPLICABILITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS PROPERTIES & APPLICABILITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMER PROPERTIES & APPLICABILITY G) Polyacrylic acid Hydrogel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN GASTRORETENTIVE DRUG DELIVERY SYSTEMS (GRDDS) ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN CONTROLLED DDS ,[object Object],[object Object],[object Object],SYNTHETIC POLYMER APPLICABILITY Poly (DL- lactide- co- glycolide) microsphere For Live Rotavirus vaccine, For encapsulating ß - lactoglo- bulin microspheres Polyacrylic acid Polyanion excipient to shield Transforming Growth Factor (TGF) from inactivation with Alginates Poly- Ɛ- caprolactone nanoparticles For encapsulating Cyclosporine A Polyester Tetanus Toxoid (vaccine) encapsulating microspheres for single- injection immunization

SYNTHETIC POLYMERS USED IN CONTROLLED & TARGETED DRUG DELIVERY SYSTEMS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMER PROPERTIES & APPLICABILITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMER APPLICABILITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SYNTHETIC POLYMERS USED IN MICELLAR DRUG DELIVERY SYSTEM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

POLYMER VESCICLES ,[object Object],SYNTHETIC POLYMER APPLICABILITY Non-ionic Polyethylene-oxide- Poly butadiene To form vesicles in aqueous solution PMOXA- PDMS- PMOXA Water soluble & midblock is hydrophilic (PEO- Polyethylethylene To form polymerosomes in aqueous solution for encapsulating Doxorubicin

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

Recent updates in synthetic polymers used in drug delivery systems

Recent updates in synthetic polymers used in drug delivery systems

Recomendados

Recomendados

Mais conteúdo relacionado

Mais procurados

Mais procurados (20)

Semelhante a Recent updates in synthetic polymers used in drug delivery systems

Semelhante a Recent updates in synthetic polymers used in drug delivery systems (20)

Último

Último (20)

Recent updates in synthetic polymers used in drug delivery systems