Original research presented orally at the 2006 Southeastern Psychological Association Meeting

1. Effect of a GABA Antagonist on Ethanol-Induced Taste Aversions Joseph Tkacz , M.S. Stephen H. Hobbs , Ph.D. Ralph L. Elkins , Ph.D.

6. Research with Animal Lines

7. Research with Animal Lines Cont.

8. Our interest: What mechanisms are involved in the aversive response to ethanol by TAP animals?

13. Pre Post Consummatory Forced Consummatory Dependent Group Injection Drink Injection Variable Hypothesis (CS) ( UCS) _______________________________________________________________________________ A Strong Conditioning Saline -> Saccharin -> Ethanol -> Two Bottle Aversion Test B Weaker Low Drug Picrotoxin -> Saccharin -> Ethanol -> Two Bottle Aversion Experimental .5 mg/kg Test C Weakest High Drug Picrotoxin -> Saccharin -> Ethanol -> Two Bottle Aversion Experimental 1 mg/kg Test D No Pseudo- Picrotoxin -> H20 -> Ethanol -> Two Bottle Aversion Conditioning 1 mg/kg Test Control E No Injection Picrotoxin -> Saccharin -> Saline -> Two Bottle Aversion Control 1 mg/kg Test