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광우병에서
구글까지
전문가가 되어버리다
M/M
Methionine=Met , Valine = Val
영국인 은
한국 사람은
gtg/atg
dbSNP
단지 하나 차이일뿐인데
단일염기 다형성
(SNP, Single Nucleotide
    Polymorphism)
23
     99.9%
44%   22%              19%




            56%


                  1%
30
인간 유전체 연구
...
점점 커져가는데
생물학 데이터에 대해서
유전체 연구
GeneBank
     Cluster                         SWISS-PROT
               Super Computer
     Hardware                             Database           Biomedical text analysis
                                                         Information
                                                           Retrieval
                  Genomic Variation
                     Research                                  Sequence alignment
                                                        Algorithm
 Machine Learning
Classfication

              Personalized
             Clustering
         Pattern recognition

        Agent
               Medicine
                   Information filtering
                     Monitoring agent


   Personal Genome
                          IT
Machine Learning




               Toby Segaran
         Biotech software company
Sequence Search with MPI
GPU
(Taverna, Myexperiment)
(Folding@Home, Korea@Home)
- foldit
(FreeBase)
Multidimensional Scaling(MDS)
(CEU),         (YRI),   (JPT),   (CHB)
KSNP(Korean SNP) Browser
Genome Browser with Google Maps API
BioBlogRSS:
!
32 Node X86
18 Node IA2 Cluster
                                        Cluster


                                       NAS, DAS
                                        Storage
                                      Workstation
                      100 Node PPC
                         Cluster
해결 해야 할 문제점
...ATTAGGACCAATAAGTCT...
                                                              Person 1 +
  ...ATTAGGAGCAATAAGTCT...

  ...ATTAGGAGCAATAACTCT...
                                                              Person 2 -
  ...ATTAGGAGCAATAAGTCT...
         0.5M SNP, cohort of 5K individuals, 10k random data set
                               Text
        Single locus                          Pair of locii




         (+,-)                                     (+,-)
Cost = 0.5M x 5k x 10k             Cost = 1/2 x 0.5M x 0.5M x 5k x 10k


      1 day                                   120 yr
       Computational problem
구글과 생명 공학의 만남
Google Health BETA
SNP
?
?
원하는것은
4.*(#/,'(5
        Hong ChangBum
        Center for Genome Science
        NIH, KCDC !quot;0*$1,.23quot;'
        hongiiv@gmail.com
          !quot;#quot;$%"'()*&$+,-.#/,'(
          !quot;#$%&'()*!'+,-.#&
        http://socmaster.homelinux.org/~hongiiv
   /++0122quot;3#4-!'5*quot;#$%&'(-(*+

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