SlideShare uma empresa Scribd logo
1 de 51
Renal Development & Dysplasia Part I Hsiao Lai, MD Feb 19, 2010 ECU, Brody School of Medicine Nephrology and Hypertension Pediatric Nephrology Core Curriculum
Where will you encounter Renal Dysplasia? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Congenital Anomalies of  Kidney and Urinary tract  (CAKUT) ,[object Object],[object Object],[object Object],[object Object],[object Object],Woolf et. Al: in Renal Dysplasia Birth Defects Monitoring Program
Causes of Pediatric ESRD % 23 Other 3 PKD 3 Cystinosis 5 Nephronophthises 8 Congenital Nephrotic Syndrome 18 Acquired GN 40 CAKUT
Common Congenital Renal Anomalies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Common Urogenital Anomalies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Congenital Renal Anomalies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Intermediate mesoderm
Renal Development ,[object Object],[object Object],[object Object],[object Object],[object Object]
Formation of Fetal Kidney ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal and Urogenital Development ,[object Object],[object Object],[object Object],[object Object]
Urogenital Development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Later Stages of Nephrogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Late Nephrogenesis
Mechanisms of Maldevelopment  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Edith Louise Potter ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Euro J Pediatrics 1994
Potter’s Syndrome ,[object Object],[object Object],[object Object]
Normal Kidneys
“ Dysplastic” Kidneys ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Multicystic Dysplastic Kidney ,[object Object],[object Object],[object Object]
Multicystic Dysplastic Kidney ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MCDK
ARPKD ,[object Object],[object Object],[object Object],[object Object]
ARPKD ,[object Object],[object Object],[object Object],[object Object]
ARPKD Cortical cysts form in collectng duct
ADPKD on Fetal US
Radiographic Appearance of  ARPKD vs ADPKD
ADPKD kennythekidney.com
Renal Hypoplasia ,[object Object],[object Object],[object Object]
Decreased Nephron Number ,[object Object],[object Object],[object Object],[object Object],[object Object]
Duplex Kidney and Ureters ,[object Object],[object Object],[object Object]
Weigert-Meyer Law Upper Pole Moiety: obstructed Lower Pole Moiety: refluxes
Weigert-Meyer Law ,[object Object],[object Object],[object Object]
Duplex Kidney and Ureters ,[object Object],[object Object],[object Object]
 
Abnormalities of Renal Fusion, Ascent and Rotation  ,[object Object],[object Object],[object Object],[object Object]
Abnormalities of Ascent and Rotation Horseshoe kidney Cross fused ectopia
Horseshoe Kidney ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Crossed-Fused Ectopia ,[object Object],[object Object],[object Object]
Pelvic/Ectopic Kidney ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
 
Bladder Outlet Obstruction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
UPJ Obstruction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
UPJ Obstruction ,[object Object],[object Object],[object Object],[object Object]
UPJ Obstruction
Posterior Urethral Valves ,[object Object],[object Object],[object Object],[object Object],[object Object]
Posterior Urethral Valves ,[object Object],[object Object],[object Object]
PUV
Management PUV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Congenital Syndromes with Renal Anomalies ,[object Object],[object Object],[object Object],[object Object]

Mais conteúdo relacionado

Mais procurados

Megaureter ppt. Types, pathophysiology, evaluation and management.
Megaureter ppt. Types, pathophysiology, evaluation and management.Megaureter ppt. Types, pathophysiology, evaluation and management.
Megaureter ppt. Types, pathophysiology, evaluation and management.Hussain Shah
 
Posterior Urethral Valves
Posterior Urethral ValvesPosterior Urethral Valves
Posterior Urethral ValvesEfosa Aimien
 
Vesicouretric reflux
Vesicouretric refluxVesicouretric reflux
Vesicouretric refluxsanyal1981
 
Congenital anomalies of the kidney and urinary tract
Congenital  anomalies of the kidney and urinary tractCongenital  anomalies of the kidney and urinary tract
Congenital anomalies of the kidney and urinary tractDhanya Raghu
 
Developmental anomalies of Renal system
Developmental anomalies of Renal systemDevelopmental anomalies of Renal system
Developmental anomalies of Renal systemsudarshan731
 
Congenital anomaly of urinary system.
Congenital anomaly of urinary system.Congenital anomaly of urinary system.
Congenital anomaly of urinary system.SANJAY SIR
 
Ectopic ureter & ureterocoele
Ectopic ureter & ureterocoeleEctopic ureter & ureterocoele
Ectopic ureter & ureterocoeleGAURAV NAHAR
 
Ultrasound of pancreas and spleen
Ultrasound of pancreas and spleenUltrasound of pancreas and spleen
Ultrasound of pancreas and spleenVikas Yadav
 
Diagnostic Imaging of Congenital Renal Anomalies
Diagnostic Imaging of Congenital Renal AnomaliesDiagnostic Imaging of Congenital Renal Anomalies
Diagnostic Imaging of Congenital Renal AnomaliesMohamed M.A. Zaitoun
 
Development and congenital anomalies of urogenital system
Development and congenital anomalies of urogenital systemDevelopment and congenital anomalies of urogenital system
Development and congenital anomalies of urogenital systemJayeta Choudhury
 
Posterior urethral valves- Pediatric Surgery
Posterior urethral valves- Pediatric SurgeryPosterior urethral valves- Pediatric Surgery
Posterior urethral valves- Pediatric SurgerySelvaraj Balasubramani
 
Flexible Uretero-renoscopy or RIRS
Flexible Uretero-renoscopy or RIRSFlexible Uretero-renoscopy or RIRS
Flexible Uretero-renoscopy or RIRSGAURAV NAHAR
 
Renal Hypoplasia FINAL OUTPUT by Nica Valencia
Renal Hypoplasia FINAL OUTPUT by Nica ValenciaRenal Hypoplasia FINAL OUTPUT by Nica Valencia
Renal Hypoplasia FINAL OUTPUT by Nica ValenciaNica Valencia
 
Congenital abnormalities of kidney and urinary system
Congenital abnormalities of kidney and urinary systemCongenital abnormalities of kidney and urinary system
Congenital abnormalities of kidney and urinary systemSUNIL KUMAR PEDDANA
 

Mais procurados (20)

Megaureter ppt. Types, pathophysiology, evaluation and management.
Megaureter ppt. Types, pathophysiology, evaluation and management.Megaureter ppt. Types, pathophysiology, evaluation and management.
Megaureter ppt. Types, pathophysiology, evaluation and management.
 
Posterior Urethral Valves
Posterior Urethral ValvesPosterior Urethral Valves
Posterior Urethral Valves
 
Antenatal Hydronephrosis
Antenatal HydronephrosisAntenatal Hydronephrosis
Antenatal Hydronephrosis
 
Vesicouretric reflux
Vesicouretric refluxVesicouretric reflux
Vesicouretric reflux
 
Congenital anomalies of the kidney and urinary tract
Congenital  anomalies of the kidney and urinary tractCongenital  anomalies of the kidney and urinary tract
Congenital anomalies of the kidney and urinary tract
 
Developmental anomalies of Renal system
Developmental anomalies of Renal systemDevelopmental anomalies of Renal system
Developmental anomalies of Renal system
 
Congenital anomalies ppt
Congenital anomalies pptCongenital anomalies ppt
Congenital anomalies ppt
 
Posterior urethral valve
Posterior urethral valvePosterior urethral valve
Posterior urethral valve
 
Congenital anomaly of urinary system.
Congenital anomaly of urinary system.Congenital anomaly of urinary system.
Congenital anomaly of urinary system.
 
Ectopic ureter & ureterocoele
Ectopic ureter & ureterocoeleEctopic ureter & ureterocoele
Ectopic ureter & ureterocoele
 
Biliary atresia
Biliary atresiaBiliary atresia
Biliary atresia
 
Ultrasound of pancreas and spleen
Ultrasound of pancreas and spleenUltrasound of pancreas and spleen
Ultrasound of pancreas and spleen
 
Diagnostic Imaging of Congenital Renal Anomalies
Diagnostic Imaging of Congenital Renal AnomaliesDiagnostic Imaging of Congenital Renal Anomalies
Diagnostic Imaging of Congenital Renal Anomalies
 
Development and congenital anomalies of urogenital system
Development and congenital anomalies of urogenital systemDevelopment and congenital anomalies of urogenital system
Development and congenital anomalies of urogenital system
 
Posterior urethral valves- Pediatric Surgery
Posterior urethral valves- Pediatric SurgeryPosterior urethral valves- Pediatric Surgery
Posterior urethral valves- Pediatric Surgery
 
Flexible Uretero-renoscopy or RIRS
Flexible Uretero-renoscopy or RIRSFlexible Uretero-renoscopy or RIRS
Flexible Uretero-renoscopy or RIRS
 
Nephrolithiasis
NephrolithiasisNephrolithiasis
Nephrolithiasis
 
Hydronephrosis
HydronephrosisHydronephrosis
Hydronephrosis
 
Renal Hypoplasia FINAL OUTPUT by Nica Valencia
Renal Hypoplasia FINAL OUTPUT by Nica ValenciaRenal Hypoplasia FINAL OUTPUT by Nica Valencia
Renal Hypoplasia FINAL OUTPUT by Nica Valencia
 
Congenital abnormalities of kidney and urinary system
Congenital abnormalities of kidney and urinary systemCongenital abnormalities of kidney and urinary system
Congenital abnormalities of kidney and urinary system
 

Semelhante a Renal Development Dysplasia 2

13. oldIntroduction to nephrology 1 & 2.ppt
13. oldIntroduction to nephrology 1 & 2.ppt13. oldIntroduction to nephrology 1 & 2.ppt
13. oldIntroduction to nephrology 1 & 2.pptYusuphShittu
 
Fetal genitourinary
Fetal genitourinaryFetal genitourinary
Fetal genitourinarydypradio
 
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).ppt
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).pptCongenital Anomalies of the Kidney and the Urinary Tract (CAKUT).ppt
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).pptIslombekOchildiev
 
Kidney embryology & its clinical implications
Kidney embryology & its clinical implicationsKidney embryology & its clinical implications
Kidney embryology & its clinical implicationsDr. Khaled Elzorkany
 
Posterior urethral valve
Posterior urethral valvePosterior urethral valve
Posterior urethral valveMakafui Yigah
 
Embryology of genitourinary system
Embryology of genitourinary systemEmbryology of genitourinary system
Embryology of genitourinary systemMilan Silwal
 
Congenital Anomalies Of UG System PATHOLOGY.pptx
Congenital Anomalies Of UG System PATHOLOGY.pptxCongenital Anomalies Of UG System PATHOLOGY.pptx
Congenital Anomalies Of UG System PATHOLOGY.pptxirtzaali420
 
Radiology of urogenital systsm slide share
Radiology of urogenital systsm slide shareRadiology of urogenital systsm slide share
Radiology of urogenital systsm slide shareREKHAKHARE
 
Pediatric renal cystic diseases
Pediatric renal cystic diseasesPediatric renal cystic diseases
Pediatric renal cystic diseasesMoosaAllawati1
 
Obstructive Uropathy "online"
Obstructive Uropathy "online"Obstructive Uropathy "online"
Obstructive Uropathy "online"Ayman Rashed, MD
 
Pelvi ureteric junction obstruction in children
Pelvi ureteric junction obstruction in childrenPelvi ureteric junction obstruction in children
Pelvi ureteric junction obstruction in childrenAseesh Varma
 
kidney_and_ureters.ppt
kidney_and_ureters.pptkidney_and_ureters.ppt
kidney_and_ureters.pptDrSamiyahSyeed
 
kidney_and_ureters.ppt
kidney_and_ureters.pptkidney_and_ureters.ppt
kidney_and_ureters.pptDrSamiyahSyeed
 
Congenital Anomalies of Kidney bt dr. shahariar
Congenital Anomalies of Kidney bt dr. shahariarCongenital Anomalies of Kidney bt dr. shahariar
Congenital Anomalies of Kidney bt dr. shahariarshahariarhossainshaw
 
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)Durre Sabih
 
Hydronephrosis Dr Lokku
Hydronephrosis   Dr LokkuHydronephrosis   Dr Lokku
Hydronephrosis Dr Lokkuranga0007
 
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptxCONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptxXavier875943
 

Semelhante a Renal Development Dysplasia 2 (20)

13. oldIntroduction to nephrology 1 & 2.ppt
13. oldIntroduction to nephrology 1 & 2.ppt13. oldIntroduction to nephrology 1 & 2.ppt
13. oldIntroduction to nephrology 1 & 2.ppt
 
Fetal genitourinary
Fetal genitourinaryFetal genitourinary
Fetal genitourinary
 
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).ppt
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).pptCongenital Anomalies of the Kidney and the Urinary Tract (CAKUT).ppt
Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT).ppt
 
Kidney embryology & its clinical implications
Kidney embryology & its clinical implicationsKidney embryology & its clinical implications
Kidney embryology & its clinical implications
 
Antenatal hydronephrosis
Antenatal hydronephrosisAntenatal hydronephrosis
Antenatal hydronephrosis
 
Posterior urethral valve
Posterior urethral valvePosterior urethral valve
Posterior urethral valve
 
Embryology of genitourinary system
Embryology of genitourinary systemEmbryology of genitourinary system
Embryology of genitourinary system
 
Fetal urogenital usg
Fetal urogenital usgFetal urogenital usg
Fetal urogenital usg
 
Congenital Anomalies Of UG System PATHOLOGY.pptx
Congenital Anomalies Of UG System PATHOLOGY.pptxCongenital Anomalies Of UG System PATHOLOGY.pptx
Congenital Anomalies Of UG System PATHOLOGY.pptx
 
Radiology of urogenital systsm slide share
Radiology of urogenital systsm slide shareRadiology of urogenital systsm slide share
Radiology of urogenital systsm slide share
 
Renal anomalies
Renal anomaliesRenal anomalies
Renal anomalies
 
Pediatric renal cystic diseases
Pediatric renal cystic diseasesPediatric renal cystic diseases
Pediatric renal cystic diseases
 
Obstructive Uropathy "online"
Obstructive Uropathy "online"Obstructive Uropathy "online"
Obstructive Uropathy "online"
 
Pelvi ureteric junction obstruction in children
Pelvi ureteric junction obstruction in childrenPelvi ureteric junction obstruction in children
Pelvi ureteric junction obstruction in children
 
kidney_and_ureters.ppt
kidney_and_ureters.pptkidney_and_ureters.ppt
kidney_and_ureters.ppt
 
kidney_and_ureters.ppt
kidney_and_ureters.pptkidney_and_ureters.ppt
kidney_and_ureters.ppt
 
Congenital Anomalies of Kidney bt dr. shahariar
Congenital Anomalies of Kidney bt dr. shahariarCongenital Anomalies of Kidney bt dr. shahariar
Congenital Anomalies of Kidney bt dr. shahariar
 
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)
Antenatal diagnosis of Congenital Anomalies of Kidneys and Urinary Tract (CAKUT)
 
Hydronephrosis Dr Lokku
Hydronephrosis   Dr LokkuHydronephrosis   Dr Lokku
Hydronephrosis Dr Lokku
 
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptxCONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
 

Renal Development Dysplasia 2

Notas do Editor

  1. Intermediate mesoderm on either side of the dorsal body wall/notochord gives rise to 3 successive nephric structures of increasingly advanced design
  2. Pronephroi- nonfunctional segmental nephrotomes which develop in cervical region-represent a vestige of primitive kidneys seen in lower vertebrates, begin to appear at 24 days and regress in the fourth week Mesonephros – initial appearance of mesonephros and mesonephric duct at 25 days. Metanephric blastema and metanephric ducts appear at 28 days or end of week 4 Mesonephros develop in thoracic and lumbar regions during 4 th week, functional with complete but simple nephrons drained by the mesonephric (Wolffian Ducts) Nephric ducts grow caudally to open into the posterior wall of the primitive urogenital sinus by week 5 Metanephroi-definitive kidneys begin to form during 5 th week by induction of sacral intermediate mesoderm by UBs
  3. UBs sprout from the distal end of the mesonephric duct by week 5