Polypharmacy+in+Schizophrenia

Antipsychotic Combinations or ‘Polypharmacy’ Rationale Combination Antipsychotic Medication Usage

“ These Are but Shadows of the Things That Have Been,'' Said the Ghost. A Christmas Carol Charles Dickens

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Antipsychotic Combinations vs. Monotherapy in Schizophrenia

Increasing use of Polypharmacy ,[object Object],[object Object],Miller AL et al. Clin Psychiatry (2004) 65:(4):500–508

Drug Response Dependent on 3 Variables: 2. Drug Concentration Absorption Distribution Metabolism Elimination 1. Affinity Receptors Enzymes Uptake Pumps 3. Patient Genetics Age Disease Environment Clinical Response Adapted from Preskorn S. J Pract Psychiatry Behav Health . 1999;5:50-55.

Antipsychotic polytherapy - Relevance ,[object Object],[object Object],Correll et al. Schizophr Res. 2007;89(1-3):91-100.

Antipsychotic Combinations vs Monotherapy Christoph Et al. Schizophrenia Bulletin. 2008

Finding of superior efficacy of antipsychotic co-treatment ,[object Object],[object Object],[object Object],Christoph Et al. Schizophrenia Bulletin. 2008

Antipsychotic augmentation strategies ,[object Object],[object Object],[object Object],Christoph Et al. Schizophrenia Bulletin. 2008

Clozapine co-initiated ,[object Object],Christoph Et al. Schizophrenia Bulletin. 2008

Algorithm Philosophy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Some Causes of Polypharmacy: ,[object Object],[object Object],[object Object]

ALGORITHM - Aligning the Arrows ,[object Object]

PennMAPS Antipsychotic Algorithm

PennMAPS Antipsychotic Algorithm (Cont’d)

Long-term Safety of Co-treatments ???? ,[object Object],[object Object]

Conclusion – I ,[object Object],[object Object],[object Object],[object Object],[object Object]

Conclsion - II ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rune AK et al. BMC Psychiatry 2009, 9:24

Conclusion - III ,[object Object],[object Object],[object Object],[object Object]

Polypharmacy+in+Schizophrenia

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