Renal Tubular Acidosis

TUBULAR FUNCTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acidosis & anion gap ,[object Object],[object Object],[object Object]

Normal Urinary Acidification ,[object Object],[object Object],[object Object],[object Object],[object Object]

DEFINITION ,[object Object],[object Object],[object Object]

TYPES OF RTAs ,[object Object],[object Object],[object Object]

Proximal ( Type II ) Renal Tubular Acidosis ,[object Object],[object Object]

Proximal (Type II) Renal Tubular Acidosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical Manifestations of Proximal RTA and Fanconi Syndrome. ,[object Object]

Distal (Type I) Renal Tubular Acidosis ,[object Object],Distal RTA occurs as the result of impaired distal urinary acidification (hydrogen ion secretion). Primary or secondary causes can result in damaged or impaired functioning of one or more transporters or proteins involved in the acidification process, including the H+/ATPase, the HCO3-/Cl- anion exchangers or the components of the aldosterone pathway. Because of impaired hydrogen ion excretion, urine pH cannot be reduced below 5.5, despite the presence of severe metabolic acidosis. Loss of sodium bicarbonate results in hyperchloremia and hypokalemia. Hypercalciuria is usually present and may lead to nephrocalcinosis or nephrolithiasis. Chronic metabolic acidosis also impairs urinary citrate excretion. Hypocitraturia further increases the risk of calcium deposition in the tubules. Bone disease is common, resulting from mobilization of organic components from bone to serve as buffers to chronic acidosis. Both primary sporadic or inherited forms occur. As with proximal RTA, distal RTA can also occur as a complication of either inherited or acquired diseases of the distal tubules.

Distal (Type I) Renal Tubular Acidosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Distal (Type I) Renal Tubular Acidosis ,[object Object],[object Object]

Hyperkalemic (Type IV) Renal Tubular Acidosis ,[object Object],[object Object]

Hyperkalemic (Type IV) Renal Tubular Acidosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diagnosis of RTA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diagnosis of RTA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment of RTA ,[object Object],[object Object],[object Object],[object Object]

Treatment of RTA cont. ,[object Object],[object Object],[object Object]

Renal Tubular Acidosis

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Renal Tubular Acidosis