This document discusses food-drug interactions, including how foods can impact drug absorption, distribution, metabolism, and excretion. It provides examples of how foods and nutrients can interact with medications to decrease or increase their intended effects. Specifically, it outlines how foods can influence the pharmacokinetics of drugs by altering absorption, enzyme activity, and nutrient levels in ways that either enhance or reduce drug efficacy and safety.
2. DEFINITION
Drug-nutrient interaction: the result of
the action between a drug and a nutrient
that would not happen with the nutrient or
the drug alone.
Food-drug interaction: a broad term that
includes drug-nutrient interactions and the
effect of a medication on nutritional status.
3. Food-Drug Interaction
For example, a drug that causes chronic nausea or
mouth pain may result in poor intake and weight
loss.
4. BENEFITS OF MINIMISING DRUG
INTERACTION
Medications achieve their intended effects.
Patients do not discontinue their drug.
The need for additional medication is minimized.
Fewer caloric or nutrient supplements are required.
Adverse side effects are avoided.
Optimal nutritional status is preserved.
Accidents and injuries are avoided.
Disease complications are minimized.
The cost of health care services is reduced.
There is less professional liability.
Licensing agency requirements are met.
5. DRUG EFFECTS ON FOOD INTAKE
Increased appetite (antihistamines,
psychotropic drugs and steroids)
Decreased appetite(amphetamines, insulin
and alcohol)
Taste changes(chelating agents and
diuretics)
Nausea (cardiac glycosides )
Bulking effects (methylcellulose and other
dietary fiber products)
6. DRUG EFFECTS ON NUTRIENT
ABSORPTION AND METABOLISM
Increased nutrient absorption (cimetidine
and ranitidine)
Decrease nutrient
absorption(colchicine, alcohol, laxatives, an
tibiotic neomycin)
Mineral depletion (diuretics, chelating
agents, alcohol, antacids, aspirin)
Vitamin depletion(vitamin antagonists, oral
contraceptives)
7. OUTCOMES OF DRUG AND NUTRIENT
INTERACTIONS
BENEFICIAL EFFECTS:
Infectious disease control
Control of cancer
Prevention of thromboses
Treatment of metabolic disease
Prevention of acute drug toxicity
8. To be continued :
ADVERSE EFFECTS:
Loss of drug efficacy
Drug- induced nutritional deficiencies
Toxic reactions
Blocked feeding tubes
10. To be continued:
DRUG AFFECTED
NUTRIENTS
POSSIBLE
MECHANISM
EFFECT
CHOLESTYRAMINE Fat , vitamin
A,D,K,B12,folate iron
Complex formation
bleeding, steatorrhoea
Anaemia ,osteomalacia
COLCHICINE Fat, β-carotene, Na,K,
vitamin B12
Mucosal damage Anaemia , lethargy
CORTICOSTEROIDS Calcium Decreased Ca, vitamin
D metabolism
Bone disorders
COUMARIN
ANTICOGULANTS
Vitamin K ? Hemorrhage
DIURETICS Zn , Ca, K, Mg Urinary loss depression Weakness , electrolyte
imbalance
FRUSEMIDE Thiamin Urinary loss Cardiac muscle
weakness
GLUTETHIMIDE Calcium Enzyme induction,
altered calcium
metabolism
Weakness, osteopenia
11. To be continued:
DRUG AFFECTED
NUTRIENTS
POSSIBLE
MECHANISM
EFFECT
HARMONAL
CONTRACEPATIVES
STEROIDS
Riboflavin , Folate Enzyme induction,
decreased absorption,
competition for binding
of the enzymes
Metabolic errors,
depression
HYDRALAZINE Pyridoxine Complex formation Peripheral neuropathy
ISONIAZED (INH) Pyridoxine Complex formation Peripheral neuropathy,
Convulsions, psychatric
manifestation
LAXATIVE (MINERAL
OILS)
Vitamin D Enzyme inhibition Osteopenia
LEVODOPA Nicotinic acid Competitive inhibition
coenzyme and vitamin
B6 deficiency
Pellagra
NEOMYCIN Vitamin A,D,E,K,
B12,Ca,
pyridoxine
Mal-absorption,
complex formation,
Mucosal damage,
binding of bile salts
Osteomalacia,
Peripheral neuropathy
12. To be continued:
DRUG AFFECTED
NUTRIENTS
POSSIBLE
MECHANISM
EFFECT
PARA – AMINO
SALICYCLIC (PAS)
Vitamin B12 decreased absorption Megaloblastic anaemia
D-PENICILLAMINE Pyridoxine ,Zn, Cu Complex formation Peripheral neuropathy,
Anemia
POTASSIUM
CHLORIDE
Vitamin B12 decreased ileal Ph Decreased absorption
RIFAMPCIN Vitamin D Enzyme induction Osteomalacia
SALICYLATES Vitamin C, Folate Increased excretion,
decreased uptake
Anemia ,infection
NEOMYCIN Vitamin A,D,E,K,
B12,Ca,
pyridoxine
Mal-absorption,
complex formation,
Mucosal damage,
binding of bile salts
Osteomalacia,
Peripheral neuropathy
SULPHASALAZINE Folate Mucosal block Decreased absorption
TETRACYCLINE Iron , vitamin C Chelation Decreased absorption
13. TYPES:
1. Pharmacodynamic Interactions: which
affect the pharmacologic action of the
drug.
1. Pharmacokinetic Interaction: which
affect the movement of the drug
into, around, out of the body.
14. PHARMACODYNAMICS
Pharmaco-dynamics is the study of the biochemical
and physiologic effects of a drug.
The mechanism of action, e.g. how a drug works
Often the drug molecule binds to a receptor, enzyme,
or ion channel, producing a physiological response
15. PHARMACOKINETICS
Pharmacokinetics is the study of the
time course of a drug in the body
involving absorption, distribution,
metabolism (biotransformation), and
excretion of the drug.
16. ABSORPTION :
Absorption is the process of the movement of the drug from the site
of administration to the blood-stream.
This process is dependent on the
(1) route of administration,
(2) the chemistry of the drug and its ability to cross biologic
membranes,
(3.) the rate of gastric emptying & gastrointestinal movement, and
(4.) the quality of product formulation
Food, food components and nutritional supplements can interfere
with the absorption process, especially when the drug is
administered orally.
17. Absorption
Swallowing
Disintegration
tablet swells
breaks up
Dissolution
reactions with acid
faster when ionized
Absorption
most post pyloric
in basic environment
require non-ionized state
18. Food Interactions with Absorption
Milk products alter pH
Metals chelate some medications
Some foods compete for same absorption sites
Food speeds GI speed – reduced absorption
Degree of significance is important
19. DISTRIBUTION:
Distribution occurs when the drug leaves the
systemic circulation and moves to various parts of
the body
Drugs in the bloodstream are often bound to
plasma proteins; only unbound drugs can leave the
blood and affect target organs
Low serum albumin can increase availability of
drugs and potentiate their effects
20. Metabolism (biotransformation)
Primarily in the liver; cytochrome P-450 enzyme
system facilitates drug metabolism; metabolism
generally changes fat soluble compounds to water
soluble compounds that can be excreted
Foods or dietary supplements that increase or inhibit
these enzyme systems can change the rate or extent of
drug metabolism
21. Metabolism – Interaction with food
Cytochrome P-450 in
GI, liver Grapefruit juice
made from frozen
concentrate will alter
this enzyme
Many drugs for AIDS,
HTN
Effects occur 24 hours
after ingestion
22. EXCRETION
Drugs are eliminated from the body as an
unchanged drug or metabolite
Renal excretion the major route of elimination;
affected by renal function and urinary pH
Some drugs eliminated in bile and other body
fluids
23. Excretion
Urine acidity will
change drug
excretion
Cranberry juice
will alter pH and
cause higher
dissolution. This
occurs with
sulfonamides
Lime juice is most
acidic
24. PHARMACOGENOMICS
Genetically determined variations that are
revealed solely by the effects of drugs
Affect only a subset of people
Examples include G6PD (glucose-6-phosphate
dehydrogenase) enzyme deficiency, warfarin
resistance, and slow inactivation of isoniazid
(IHN) or phenelzine
25. SLOW INACTIVATION OF ISONIAZID OR PHENEIZINE:
Increases the risk of pyridoxine
deficiency and peripheral
neuropathy.
Slow inactivation of
phenelzine, a monoamine
oxidase inhibitor (MAOI),
increases the risk for
hypertensive crisis if foods
high in tyramine are
consumed.
26. G6PD (GLUCOSE-6-PHOSPHATE
DEHYDROGENASE) ENZYME DEFICIENCY
It can lead to : Neonatal jaundice, hemolytic anemia or
acute hemolysis.
It is also called favism.
Drugs included: aspirin, sulfonamides and
antimalerial drugs caused hemolysis and acute
anemia.
Food –drug interactions in G6PD deficiency :
Ingestion of fava beans
Vitamin C
Vitamin K
27. Warfarin
Anticoagulant used to reduce strokes
Inactivated by Vitamin K - broccoli
Enteral nutrition products contain Vitamin K.
Warfarin activity drops when nutrition given
Study shows warfarin binds to protein at pH 8