If customization of bioanalytical tools or separation materials resemble a scientific or economic bottleneck in your company, a very unique approach can help: Our proprietary technologies MATE and Autodisplay enable the development and production of coating materials for customized SPR biochips, ELISA-assays as well as separation and detox materials. Two options are possible: (A) stripping off and adhering the outer membrane of the cell, (B) adhering whole cells displaying the heterologous protein/enzyme of interest. This enables the cost-efficient production of fully customized bioanalytical tools and separation materials. On top of that, sensitivity can be enhanced significantly. Find out how Autodisplay Biotech's products and services can drive your R&D efforts and/or product portfolio to the next level.

1. ask
yourself
THE FOLLOWING
QUESTIONS!

2. HAVE YOU EVER
WISHED TO CUSTOMIZE AN
ELISA OR BIOCHIP?
1

3. HAVE YOU EVER WISHED
TO CUSTOMIZE SEPARATION OR
DETOX MATERIALS?
2

4. HAS A BIOCHIP EVER
FAILED TO DETECT ULTRA LOW
CONCENTRATIONS?
3

5. IS THE LACK OF CUSTOMIZED
(BIOANALYTICAL) TOOLS SLOWING
DOWN YOUR R&D-PROCESSES?
4

6. THERE IS
ONE
OPTION

7. FUNCTIONALISE SURFACES WITH
MEMBRANE ISOLATES FROM…
bacterial
surface
display

8. OUR TECHNOLOGY ENABLES…
OM
PP
IM
CP
SP
PASSENGER
LINKER
β-BARREL

9. … THE EXPRESSION OF PROTEINS
OM
PP
IM
ON THE SURFACE OF
BACTERIAL CELLS

10. THE OUTER MEMBRANE CAN
EASILY BE STRIPPED OFF THE CELL
GACTTCGAAGTC
TTTAAGAATGACT
TCGAAGTCTTTAT
1
GENE SEQUENCE
2
gram –
+
HOST
ORGANISM
PLASMID
3
4
NAME YOUR
PROTEIN
MEMBRANE ISOLATES FOR
COATING PURPOSES
CELL CULTURE

11. THE ASYMMETRIC MEMBRANE CAN
BE ATTACHED TO SOLID SURFACES
PEPTIDES, PROTEINS OR
FUNCTIONAL ENZYMES
HYDROPHILIC SIDE
HYDROPHOBIC SIDE
SOLID SURFACE

12. MEMBRANE ISOLATES CAN BE
USED FOR VARIOUS APPLICATIONS
MICROTITERPLATES
SPR-BIOCHIPS
SEPARATION/DETOX
MATERIALS

13. you
may
ask
HOW MANY
MOLECULES ARE LOCATED
ON THE SURFACE?

14. 100,000
–
200,000
MOLECULES/CELL

15. WHAT ARE THE BENEFITS

16. CUSTOMIZATION OF BIOANALYTIC
TOOLS / SEPEARATION MATERIALS
EVEN
multimerisation
wide range
of proteins is
possible
&
co-factors

17. OUR TECHNOLOGY DOES NOT
REQUIRE COATING ANTIBODIES
STREPAVIDIN
HRP
BIOTIN
COATING ANTIBODY
ANTIGENE
YYY
CONVENTIONAL
SYSTEMS
Y
Y
DETECTION ANTIBODY

18. FULL CONTROL OF ORIENTATION
BOOSTS BIOCHIP-SENSITIVITY
up to
factor
CONVENTIONAL
SYSTEMS
100x
ANTIGENE OR BIOMARKER
PROTEIN OR ANTIBODY

19. NATURAL IMMOBILISATION LET’S
YOU SAVE ON THE COSTS
EVEN WHOLE
CELLS CAN BE
ADHERED TO A
SURFACE
NO PURIFICATION
OF TARGET PROTEIN
NECESSARY
NO COATING
ANTIBODIES
NECESSARY

20. ?
YOU ARE INTERESTED
TRY OUR FREE MEMBRANE
ISOLATE SAMPLES