About Innate Healing & Health Realisation

1. INNATE HEALING
&
HEALTH REALISATION
BY: DR. SATYENDRA SINGH
BNYS,MD

2. WHAT DO YOU UNDERSTAND BY HEALING ?

3. HEALING MEANS
• The dictionary [Cambridge, Oxford] meaning of healing means - Helping
to make someone well again, esp. after injury
• Also psychologically healing refers to the process by which neuroses or
psychoses are resolved to the degree that leads to normal existence of a
being.[APA]
• According to various studies :

4. Author Definition Themes Sub themes
Cassell “Making whole again” Wholeness Transformation
Kubler-Ross “Becoming whole again” Wholeness Loss/ isolation
Saunders “Finding wholeness” Wholeness Suffering
Inui “Well-being & function” Narrative continuity
Siegel “A state of mind” Narrative Personal
Hammerschlag
“A harmony between the mind, the body & the
spirit”
Spirituality
Reconciliation or
restoration of belief/view
Stephens “A spiritual experience” Spirituality Transcendence
Ref: Egnew T. R. (2005). The meaning of healing: transcending suffering. Annals of family
medicine, 3(3), 255–262. https://doi.org/10.1370/afm.313

5. THEORY OF VITALITY
• Vitality is the innate healing force or self curative force within us.
• It preserves & promotes health
• It prevents and cures diseases
• As we violate ways of natural living, the innate healing mechanism, get
weakened, leading to poor health.
• Revitalising the vital force & strengthening it to restore the self-healing
mechanism of the body are primary steps in nature cure
“Neo Naturopathy”: the New Science of Healing by Louis Kuhne
Benedict Lust - Doctrine of unity of diseases

6. VITAL FORCE
• Vital force or life energy is a manifestation of the measurelessness powers of all
forms of subconsciousness & cosmic consciousness.
• Vital energy/prana is the element of life & the process of circulation of vital energy
is very important.
• As vital energy flows within living organism and help to maintain balance in
physiologically, physically, mentally & emotionally.
• Healing depends on “how much vital nerve energy we have”
• balance of vital energy is must = health

7. THEORY OF SELF- HEALING/ MEDICATRIX NATURAE
• Body has an elaborate healing mechanism that strives to maintain & restore
optimal health.
• This power is an intrinsic part of our being and makes the body capable of self-
healing.
• Adequate rest, which includes physical, physiological, mental, emotional and
sensory rest
• Curative forces carry out the restorative & regenerative processes.
• Naturopathy helps to reconnect with innate healer & the treatment process is
the way to create a conducive environment ideal for self-healing.
Wiley library: application.wiley-vch.de/books
Neo naturopathy -By Louis Kuhne

8. VITAL ECONOMY
How to prevent loss of energy How to accumulate more energy

9. PHILOSOPHICAL CONCEPT OF INNATE
HEALING IN REFERENCE TO MODERN
CONCEPT
• Vital force - efficiency of digestive system & lungs to create energy, blood &
tissue
• Vital essence - balance & harmony of endocrine & neuroendocrine system
• Vital spirit - Strength & connection of spiritual energy within & throughout
• Vital economy - Energy expenditure =energy conserved by the body

10. TYPES OF HEALING
• Healing in human body can be done by 2 means or ways depending on
physiological or pathological demand of the body:
• Regeneration
• Repair

11. LEVELS OF HEALING
• Healing in the either
(repair/regeneration) form
occur in the body at certain
levels.
• Physical or mechanical
• Mental or psychological
• Physiological

12. IMMUNITY ?
• Innate/ non- specific
• Adaptive/specific

14. Table -Components of the innate immune system.
Ref- Aristizábal B, González Á. Innate immune system. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to
Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 2. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK459455/

15. PHYSICAL ASPECT OF
INNATE HEALING

16. • Philosophically - Vitality, vital force etc.
• Physiologically is known as innate immunity or inborn healing capacity
of the body.
• Physical or mechanical innate immunity consists of skin[tight skin
junction], epithelial, mucous membrane, Cilia.
Textbook of Medical Physiology- Guyton & Hall, 19th edition

17. Fig1.Section of Skin
Fig2. How skin protects
Ref: Fitzpatrick’s Dermatology in General Medicine, chapter
22

18. Mucosa- and Skin-Associated Lymphoid
Tissues
The diffuse system of lymphoid tissues that
protect mucosal surfaces lining the
digestive, respiratory, and urogenital
systems is collectively known as MALT
(mucosa-associated lymphoid tissue).
Tissue within the MALT that guards a
particular region of the body may be further
categorized. For example, BALT (bronchi-
associated lymphoid tissue) and NALT
(nasopharynx-associated lymphoid tissue)
together defend the air passages from
foreign attack. GALT (gut-associated
lymphoid tissue) protects the gastrointestinal
tract. SALT is the diffuse collection of
immune cells that protect the skin.
Ref: Nochi T, Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006;12(32):4203-13. doi: 10.2174/138161206778743457. PMID: 17100623.

19. Author & Journal Study Outcome/Conclusion
Zhao W & et al
The Journal of
Immunology, 2005
Cytokine production by skin-derived mast
cells: endogenous proteases are
responsible for degradation of cytokines
Activated Human skin derived mast cells which
produces cytokine.
Human skin derived mast cell that produces alpha-
beta-tryptases cells produce substantial amount of
amounts of IL-5,6,3, TNF-Alpha which results in
degranulation response [immediate response to
wound, injury by releasing performing mediators into
connective tissue resulting in cellular & soluble
effectors]
Wei Zhao & et al
The Journal of
Immunology, 2008
FcγRIIa, Not FcγRIIb, Is Constitutively
and Functionally Expressed on Skin-
Derived Human Mast Cells
This are gene expressed lung mast cells. FcyRIIa
receptors present in human skin mast cells of MT-TC
[mast cell that produces alpha-beta-tryptases] extends
the response capabilities of human mast cells beyond
those associated with the IgE to include those
associated with IgG.

20. Author & Journal Study Outcome/Conclusion
W Zhang
Clinical Journal &
Experimental Immunology,
2010
Transforming growth factor
beta 1 plays an important
role in inducing
CD4+CD25+forhead box P3+
regulatory T cells by mast
cells
Bone marrow derived Mast cell[BMCCs] can also
suppress the immune response through regulatory T
cells. And CD4 T cells can be induced into CD4+,
CD25+, Foxp3+ cells by BMMCs via transforming
growth factor beta.
Margherita Zanetti
The Journal of Leuckocyte
Biology, 2004
Cathelicidins,
multifunctional
peptides of the innate
immunity
Antimicrobial peptide LL-37, PR-39(porcine) (as
discussed earlier) participates in providing innate
immunity by regulating the antimicrobial host defences

21. Author Study Outcome/ conclusion
Elizabeth G. Ibarra-
Coronado & et al
Scientific Reports (Nature),
2017
Innate immunity modulation in
the duodenal mucosa induced
by REM sleep deprivation during
infection with Trichinella spirallis
Sleep is predictor of immunity though it can affect immunity.
Study reported that those rats who were sleep deprived got
affected to Trichinella spiralis (parasite) other developed
immune response of gut mucous membrane against the
parasite.
Troy D. Randall
Elsevier Public health
emergency collection,
2010
Bronchus-
Associated
Lymphoid Tissue
(BALT)
• Dendritic cell in BALT are found in highest concentration in
T cell.
• Role in homeostatic, provides cytokines
• Also have role in neuromodulation which gets stimulated in
viral infections (in rats) leading to leucocyte recruitment to
the airways and BALT hyperplasia {as they have higher
affinity for substance P & neurokinin 1}
• BALT areas have lymphatic vessels from which DC
acquire antigen in the airway through BALT

22. Author Study Outcome/ conclusion
Elisa Casadei & Irene
Salinas
Elsevier Public Emergency
Collection, 2018
Comparative
models for human
nasal infections
and immunity
NALT prevents progression of pathogen to lower respiratory
tract or CNS
Examples are as follows :

24. PHYSIOLOGICAL & CHEMICAL ASPECT
• Homeostasis
• pH - sweat, saliva, HCL, bile, vaginal mucus, urine, tears, gut flora &
fauna
• Certain physiological responses such as diarrhoea, fever

25. Author & Journal Study Outcome/Conclusion
John A Kellum
Springer Critical Care,
2000
Determinants of blood
pH in health & disease
Important in cardiac, pulmonary physiology
Blood pH affects functioning of cell, organ, organism via
local, regional & systemic acid-base balance.
Shu-Hua Kuo & et al
Diagnostics(Basel), 2020
Role of pH value in
clinically relevant
diagnosis
pH affects function & play a critical role in regulating the
activating proteases related to wound healing processes.
pH activity of bacterial entertoxin activity antibacterial
efficacy [Table1 next slide]
Gerry K. Schwarzenberg
Journal of Environmental &
public health, 2012
The alkaline diet: is
there evidence that an
Alkaline pH diet
benefits health?
Alkaline diet = alkaline urine pH =reduced Ca in urine [Ca-
balance because of other buffers like phosphate]=improves
bone health Increased GH= improves CV health.
Increased intracellular Mg = normal functioning of numerous
enzymes, Mg activates Vit.D
[table 2next slide]

27. Author & Journal Study Outcome/Conclusion
Nimshitha
Pavathuparambli Abdul
manaph & et al
Stem cell research &
therapy, 2018
Urine derived cells for
human cell therapy
• Differentiation or transdifferentiation of human urine derived cells can
generate desirable cells for regenerative therapy
• Easy, cost effective, non invasive kind of donor based cells helps:
• Renal reconstruction/kidney bioengineering[good replacement for
epithelial, endothelial & proximal tubule cells which reduces
inflammation & tubular injury by releasing cyokine& growth factor in
turns increases vascularisation by angiogenesis]
• genitourinary repair[as endothelial cells have been known to treat
even end age of bladder disease]
• cardiac repair[induced pluripotent cell,embroyonic stem cell as urine
stem cell have proved to generate mesoderm, endoderm & ectoderm
cells]
• liver reconstruction[renal cells have high expression of the endoderm
marker Sox-17 responsible thyroid, liver, pancreas cells development]
• diabetes treatment [conversion into insulin secreting beta cells]
• neurogeneration[provide functional neurons, esp. dopaminergic which
can help in PD]
• bone engineering[due to proliferative, self-renewal, differentiate
capability of urine stem cell to develop osteoblasts] & many other
conditions

28. Author & Journal Study Outcome/Conclusion
Sahdeo Prasad & et al
Experimental Biology &
medicine, 2016
Detection of
inflammatory
biomarkers in saliva &
urine:Potential in
diagnosis, diagnosis,
prevention & treatment
for chronic diseases
Saliva & urine biomarkers are acting as diagnostic tool as
well as treatment [fig. Next slide] also helps in understanding
disease & body relation.

31. Author & Journal Study Outcome/Conclusion
Hilaire J. Thompson
Journal of Advance
nursing, 2005
Fever: a concept
analysis
Now since past 20 year fever is taken as- acute phase response
Fever is an adaptive, coordinated & systemic response to an immune
stimulus, is a self limiting response in which thermoregulatory control
remains intact & generally requires no treatment.
Misconception about fever Facts
Fevers is a cause of illness Fever is a response to illness
Fever is maladaptive Is an adaptive systemic response to immune stimuli
Fever is solely an increased body temp.
Part of coordinated acute phase response of body including
autonomic, behavioural & neuroendocrine responses
Absolute temp. To define fever (usually 100.4 degree F)
No universal temp. Is defined as is based on individuals
normal diurnal body temp.
Fever requires medical/nursing intervention to prevent
negative consequences
Fever is self-limiting & generally requires no intervention

32. Ref: Mackowiak et al (1997) &
Saper & Breder(1994)

33. CELLULAR ASPECT
• Phagocytosis
• Inflammation
• Cellular adaptation
• Cell deaths

34. Robbins Basic Pathology;Robbins & Cotran, 9th edition (Elsevier publication)
Inflammation

35. Pro-inflammatory cytokine production
Stimulus
Encourage inflammation
Local redness, swelling, heat, pain, loss of function
Depending on nature & infecting pathogen (no. of leucocytes [mainly neutrophils] arrive at site)
Both macrophage & dendritic cells engulf pathogen & cellular debris through phagocytosis
Neutrophils have 2-5 lobes with nucleus & lysosomes. Lysosomes engulf pathogen
Movement of leucocytes & fluid through increasingly permeable capillaries to infection site
Eosinophils (kind of leukocyte) act in allergic response, surrounds parasite & provide protection
PHAGOCYTOSIS

36. Cellular Adaptations

37. Cell Death

38. Author & Journal Study Outcome/Conclusion
Cornelia Hahn Martin A.
Arteriosclerosis,Thromb
osis, and Vascular
Biology, 2009
The role of
cellular
adaptation to
Mechanical
forces in
atherosclerosis
• Pressurised vascular system is an efficient, evolutionary to
circulate blood at cell or tissue level to increase metabolic output
• Mechanical pressure is generally required even in normal
conditions of CVS functioning to promote homeostasis
• Adaptive responses leads to disturbed flow later, gene
expression, matrix remodelling further contributes to
inflammatory pathways
• These events synergise with systemic risk factors (smoking,
diabetes)leading to progression of disease
Corbucci G. & et al
Minerva
Anestesiologica, 2005
Mechanism of
cell protection by
adaptation to
chronic & acute
hypoxia:
molecular
biology & clinical
practice
Adaptation to chronic hypoxia - increases tissue toleration to O2
deprivation
Promising protection have been reported by this cell
preconditioning & adaptation mimicking

39. Author & Journal Study Outcome/Conclusion
Valerie M.Weaver
Seminars in Cell &
Division Biology
(Elsevier), 2017
Cellular
adaptation to
biomechanical
stress across
length scales in
tissue
homeostasis &
disease
Mechanotransduction & matrix mechanics should be considered
while designing therapies to treat human conditions.
Extracellular matrix stiffness syngises with chemical cues to drive
single cell & collective cell behaviour in culture & act to establish
homeostasis
Valentina Fodale & et al
Cancer Journal, 2017
Mechanism of
cell adaptation.
When & how do
cancer develop
chemoresistance
?
Tumor cells develop chemoresistance & multiple mechanism can
be activated by single cell at different stages of disease
progression
Certain effects to overcome effect of pharmacological compounds -
alteration in drug metabolism, cross-talk between different
membrane receptors, modification of apoptotic signalling &
interference with cell proliferation

40. Author & Journal Study Outcome/Conclusion
Daniela N. Petrusca &
et al
Americal Journal of
Respiratory Cell &
Molecular Biology
(ATS),2014
Smoking
exposure
induces human
lung endothelial
cell adptation to
apoptotic stress
Non smoker’s certain cells (ceramide16) were introduced in
emphysema patients & found reduction In proliferation, induced
apoptosis via mitochondrial membrane depolarisation, apoptosis
inducing factor translocation, Akt phosphorylation.
Smokers develop apoptosis-resistant phenotype

41. • Mechanistic view of mind - Sigmund freud [earlier k/a the neuro-psychoses of defense]
• Unconscious mental processes employee by the ego to reduce anxiety.
• He defined defense as “in order to ward off unacceptable ideas or feelings that would cause “distressing
effect”, a person unconsciously resorts to certain mental processes that oppose these ideas or feelings and
render them less disturbing. This mental process, which take place outside the person’s awareness is called
defenses.
• Why ? Without defense mechanism people cannot live together it will be a mess if everyone will follow ones
instinctual drive.
• Also it protect our whole society & ego (upto certain level in normal condition) from some displeasure
• Also human biocultural behaviour results in healing behaviour. Which involves 1.emotional distress has
evolutionary origin 2.regulation of emotion evolved within a social context 3. There are motivators &
mechanisms of interpersonal regulation of emotion that results in consoling behaviour.
PSYCHOLOGICAL ASPECT
Ref: The ego & the mechanisms of defense: By Anna Freud
Brandon & et al- Why we heal: the evolution of psychological healing & implications for global mental health, Clinical Psychological review Vol.822020, Elsevier

42. Role of interpersonal in
responding to emotional distress

43. Psychological healing in the form
of interpersonal regulation of
emotion between social group
member
Ref: de Waal & Preston, 2017

44. NATUROPATHY MODEL OF HEALING
[Optimal health]
Normal health
Inflammation
Irritation
Chronic inflammation
Discharge
Disturbance
Ref: Jared Zeff & et al “Naturopathic model of healing- the process of healing revisited”
(tumors, ulceration, scar, atrophy)
Degeneration

45. Thank You !