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TIPS	
  
Transfers,	
  Interfaces	
  and	
  Processes	
  
Ecole	
  Polytechnique	
  de	
  Bruxelles	
  
UNIVERSITÉ	
  LIBRE	
  DE	
  BRUXELLES	
  
Prof.	
  Frédéric	
  Debaste	
  
Chargé	
  de	
  cours	
  
«	
  Drying	
  of	
  yeast	
  op0misa0on	
  »	
  
FERMENTATION	
  IN	
  THE	
  FOOD	
  INDUSTRY	
  :	
  	
  
Managing	
  Living	
  Organisms	
  to	
  op0mize	
  your	
  Produc0on	
  
Pore	
  scale	
  
Grain	
  scale	
  
Reactor	
  scale	
  
FIELDS	
  OF	
  EXPERTISE	
  
  Drying	
  (of	
  yeast)	
  opera0on	
  design	
  and	
  op0miza0on	
  
  In	
  fluidized	
  bed,	
  spray	
  dryer,	
  spouted	
  bed	
  
  Mul0scale	
  modelling	
  of	
  drying	
  
  Analysis	
  of	
  local	
  drying	
  condi0ons	
  and	
  their	
  impact	
  on	
  
drying	
  	
  
A	
  FINE	
  ANALYSIS	
  OF	
  ACTIVITY	
  LOSS	
  DURING	
  DRYING	
  
  First	
  on	
  small	
  amounts	
  of	
  yeast	
  :	
  	
  
  Analysis	
  of	
  shrinkage	
  and	
  viability	
  
  For	
  various	
  controlled	
  drying	
  condi0ons	
  
  Valid	
  for	
  a	
  strain	
  (with	
  given	
  carrier	
  and	
  encapsula0ng	
  agent)	
  
A	
  FINE	
  ANALYSIS	
  OF	
  ACTIVITY	
  LOSS	
  DURING	
  DRYING	
  
  Ini0al	
  drying	
  rate	
  is	
  the	
  key	
  phenomenon	
  	
  
  Correla0on	
  shrinkage	
  –	
  
viability	
  
A	
  FINE	
  ANALYSIS	
  OF	
  ACTIVITY	
  LOSS	
  DURING	
  DRYING	
  
  Up-­‐scaling	
  the	
  result	
  
  Directly	
  from	
  the	
  experiments	
  
  Toward	
  mathema0cal	
  modelling	
  
	
  
By	
  characterizing	
  the	
  dryer	
  
(flow,	
  temperature,	
  humidity)	
  
  Measurment	
  (pilot	
  scale)	
  
  Modelling	
  (pilot	
  and	
  industrial	
  scale)	
  	
  
	
  
A	
  FINE	
  ANALYSIS	
  OF	
  ACTIVITY	
  LOSS	
  DURING	
  DRYING	
  
  Results	
  
  x1,25	
  viability	
  at	
  pilot	
  scale	
  in	
  fluidized	
  bed	
  (at	
  fixed	
  drying	
  0me)	
  
  x1,15	
  viability	
  gain	
  if	
  going	
  to	
  spouted	
  bed,	
  but	
  further	
  op0mizable	
  
  Possibility	
  to	
  iden0fy	
  best	
  reactor	
  for	
  a	
  given	
  strain	
  
	
  
SERVICE	
  PROPOSAL	
  
	
  
AUDIT/ANALYSIS	
  	
  
RESEARCH	
  
  Faster	
  evalua0on	
  of	
  viability	
  of	
  a	
  strain	
  under	
  various	
  
drying	
  condi0ons	
  
  Reactor	
  «	
  killing	
  zone	
  »	
  iden0fica0on	
  by	
  modelling	
  
	
  
  Further	
  inves0ga0on	
  of	
  solutes	
  role	
  in	
  viability	
  	
  
  Development/op0misa0on	
  of	
  enhanced	
  dryers	
  
  Extensions	
  to	
  spray	
  drying	
  
	
  
PROF.	
  FRÉDÉRIC	
  DEBASTE	
  
Chargé	
  de	
  cours	
  
	
  	
  	
  	
  	
  	
  	
  	
  	
  fdebaste@ulb.ac.be	
  
	
  	
  	
  	
  	
  	
  	
  	
  	
  +32	
  26506756	
  
	
  
@
TIPS	
  
Transfers,	
  Interfaces	
  and	
  Processes	
  
Ecole	
  Polytechnique	
  de	
  Bruxelles	
  
UNIVERSITÉ	
  LIBRE	
  DE	
  BRUXELLES	
  

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Transfers, Interfaces and Processes (TIPs) ULB

  • 1. TIPS   Transfers,  Interfaces  and  Processes   Ecole  Polytechnique  de  Bruxelles   UNIVERSITÉ  LIBRE  DE  BRUXELLES   Prof.  Frédéric  Debaste   Chargé  de  cours   «  Drying  of  yeast  op0misa0on  »   FERMENTATION  IN  THE  FOOD  INDUSTRY  :     Managing  Living  Organisms  to  op0mize  your  Produc0on  
  • 2. Pore  scale   Grain  scale   Reactor  scale   FIELDS  OF  EXPERTISE     Drying  (of  yeast)  opera0on  design  and  op0miza0on     In  fluidized  bed,  spray  dryer,  spouted  bed     Mul0scale  modelling  of  drying     Analysis  of  local  drying  condi0ons  and  their  impact  on   drying    
  • 3. A  FINE  ANALYSIS  OF  ACTIVITY  LOSS  DURING  DRYING     First  on  small  amounts  of  yeast  :       Analysis  of  shrinkage  and  viability     For  various  controlled  drying  condi0ons     Valid  for  a  strain  (with  given  carrier  and  encapsula0ng  agent)  
  • 4. A  FINE  ANALYSIS  OF  ACTIVITY  LOSS  DURING  DRYING     Ini0al  drying  rate  is  the  key  phenomenon       Correla0on  shrinkage  –   viability  
  • 5. A  FINE  ANALYSIS  OF  ACTIVITY  LOSS  DURING  DRYING     Up-­‐scaling  the  result     Directly  from  the  experiments     Toward  mathema0cal  modelling     By  characterizing  the  dryer   (flow,  temperature,  humidity)     Measurment  (pilot  scale)     Modelling  (pilot  and  industrial  scale)      
  • 6. A  FINE  ANALYSIS  OF  ACTIVITY  LOSS  DURING  DRYING     Results     x1,25  viability  at  pilot  scale  in  fluidized  bed  (at  fixed  drying  0me)     x1,15  viability  gain  if  going  to  spouted  bed,  but  further  op0mizable     Possibility  to  iden0fy  best  reactor  for  a  given  strain    
  • 7. SERVICE  PROPOSAL     AUDIT/ANALYSIS     RESEARCH     Faster  evalua0on  of  viability  of  a  strain  under  various   drying  condi0ons     Reactor  «  killing  zone  »  iden0fica0on  by  modelling       Further  inves0ga0on  of  solutes  role  in  viability       Development/op0misa0on  of  enhanced  dryers     Extensions  to  spray  drying    
  • 8. PROF.  FRÉDÉRIC  DEBASTE   Chargé  de  cours                    fdebaste@ulb.ac.be                    +32  26506756     @ TIPS   Transfers,  Interfaces  and  Processes   Ecole  Polytechnique  de  Bruxelles   UNIVERSITÉ  LIBRE  DE  BRUXELLES