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Non-Specific Immunity
Innate (natural, native, non-specific) immunity  ,[object Object],[object Object],[object Object]
Differen ces  between the Innate and Acquired Immunity  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Differences between inntae and specific immunity
Basic components of non-specific defence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PAMPS – pathogen-associated molecular patterns ( Endotoxin , mannose, double-stranded  RNA , unmelylated CpG nucleotides )   PRR- Pattern recognition receptors  - recognize PAMPS.  TOLL-like receptors –surface or intracellular receptors recognizing  various PAMPS. Expressed on dendritic  cells, macrophages, granulocytes, epithelial cells…. They induce activation of th ese  cells.
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Activation by  Toll-like Receptors and by Cytokine Receptors
The Complement System
General features of the Complement System Activation ,[object Object],[object Object],[object Object],[object Object]
Activation of the complement sytsem
 
Complement  system  activation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  The Complement System
 
 
 
Biological effects of activated complement system ,[object Object],[object Object],[object Object],[object Object]
Phagocytosis
Phagocytic cells ,[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Polymorphonuclear granulocyte
Normal blood count  (in adults) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Macrophages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Development of macrophages
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Extravasation of leukocytes
Chemotaxins ,[object Object],[object Object],[object Object],[object Object],[object Object]
Opsonins ,[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Steps of phagocytosis
 
Killing mechanisms of phagocytic cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Lysozyme ,[object Object],[object Object]
Natural killers (NK cells) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Large granulated lymphocyte
The action of interferon (IFN )
Inflammation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
General symptoms and  signs of inflammation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 19 July 2006 06:34 AM) © 2005 Elsevier  Initiation of inflammation
Accute-phase proteins ,[object Object],[object Object],[object Object],[object Object]
Accute phase response
people.eku.edu/ritchisong/301notes4b.html   Initiation of inflammatory process
Drugs modulating inflammatory process ,[object Object],[object Object],[object Object],[object Object],[object Object]

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