This recombination process creates genetic diversity at the level of genes that reflects differences in the DNA sequences of different organisms.

1. RECOMBINATION ERROR
Or
Double stranded DNA repair
Or
Non-homologous end joining repair
Presented by
Mr.Karthick J.

2. • It is also called double stranded DNA repair
because in this phenomenon repair of the two
broken ends of the DNA takes place and protect
the genome from further degradation .
•Double stranded breaks are generated by
exposure to ionizing radiation or chemical
mutagens or during recombination events .

3. • A multi-component protein complex directs a DNA
Ligase to the break.
• The complex contains a protein called Ku, having two
non – identical subunit binds to two broken ends of
the DNA

4. • The binding of Ku is accomplished by the DNA -PK
Protein kinase.
• It activates a third protein XRCC4, which interacts with
the mammalian DNA Ligase –IV directing this repair
to join the double strands broken ends.
• Like recombination, non-homologous ends are joined
by this process.

5. • Therefore, this type of repair process is also
called non- homologous end joining repair
process.