Enviar pesquisa
Carregar
Novartis RL
•
0 gostou
•
63 visualizações
J
Joud Al-Kateb
Seguir
Denunciar
Compartilhar
Denunciar
Compartilhar
1 de 1
Baixar agora
Baixar para ler offline
Recomendados
Information about the WPC and the 2006 edition on Brazil
World Puzzle Championship Brasil
World Puzzle Championship Brasil
brandizzi
http://www.fao.org/globalsoilpartnership This presentation was made during the Central America Caribbean and Mexico Soil Partnership Workshop which took place in La Habana, Cuba 1-2 June 2015. The presentation was made by Ing. Alirio Edmundo Mendoza, and it has the objective to present Prioridades para el manejo sostenible del suelo in El Salvador. ©FAO: http://www.fao.org
El Salvador
El Salvador
FAO
Mond resume
Mond resume
Richmond Villanueva
Hahnrecommendation
Hahnrecommendation
Robert McKee
Módulo: EThICS 039.P06.05_PDI_PTI_Delineam Tópico: PESQUISA, DESENVOLVIMENTO & INOVAÇÃO + GARANTIA DE SISTEMAS E PRODUTOS Assunto: Metodologia Integrada de PDI & GSP: Delineamento do Plano de Treinamento e Implantação Escopo: SUMÁRIO DO PROGRAMA Acrônimos Motivações para o Programa Público do Programa Objetivos do Programa Níveis e Formas de Execução Escopo de Treinamentos Básicos do Programa Escopo de Implantações do Programa Plano de Execução do Programa
Metodologia de PDI & GSP: Plano de Treinamento e Implantação
Metodologia de PDI & GSP: Plano de Treinamento e Implantação
Antonio Sallum Librelato
G@S Closing Event - Introduction
G@S Closing Event - Introduction
imec
Diariodumaloira
Diariodumaloira
Pelo Siro
11662
11662
uploadpdfbooks
Recomendados
Information about the WPC and the 2006 edition on Brazil
World Puzzle Championship Brasil
World Puzzle Championship Brasil
brandizzi
http://www.fao.org/globalsoilpartnership This presentation was made during the Central America Caribbean and Mexico Soil Partnership Workshop which took place in La Habana, Cuba 1-2 June 2015. The presentation was made by Ing. Alirio Edmundo Mendoza, and it has the objective to present Prioridades para el manejo sostenible del suelo in El Salvador. ©FAO: http://www.fao.org
El Salvador
El Salvador
FAO
Mond resume
Mond resume
Richmond Villanueva
Hahnrecommendation
Hahnrecommendation
Robert McKee
Módulo: EThICS 039.P06.05_PDI_PTI_Delineam Tópico: PESQUISA, DESENVOLVIMENTO & INOVAÇÃO + GARANTIA DE SISTEMAS E PRODUTOS Assunto: Metodologia Integrada de PDI & GSP: Delineamento do Plano de Treinamento e Implantação Escopo: SUMÁRIO DO PROGRAMA Acrônimos Motivações para o Programa Público do Programa Objetivos do Programa Níveis e Formas de Execução Escopo de Treinamentos Básicos do Programa Escopo de Implantações do Programa Plano de Execução do Programa
Metodologia de PDI & GSP: Plano de Treinamento e Implantação
Metodologia de PDI & GSP: Plano de Treinamento e Implantação
Antonio Sallum Librelato
G@S Closing Event - Introduction
G@S Closing Event - Introduction
imec
Diariodumaloira
Diariodumaloira
Pelo Siro
11662
11662
uploadpdfbooks
En el Siglo 21
La Informática Educativa y la Docencia Universitaria
La Informática Educativa y la Docencia Universitaria
Jorge Francisco Vera Mosquera
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF Maté Ongenaert (Mechelen, Belgium), Maté Ongenaert, Sonia Dupont, Roland Blanqué, Reginald Brys, Ellen van der Aar, Bertrand Heckmann ERS - European Respiratory Society International Congress 2016. Session: Therapeutic horizons: novel targets and pharmacological models Background and objectives GLPG1690 is a novel potent autotaxin (ATX) inhibitor shown to be efficacious in the mouse bleomycin (BLM) lung fibrosis model. Here, we analyze the impact of GLPG1690 on the gene expression signature in mouse fibrotic lung tissue. Methods Lung fibrosis was induced by intranasal administration of BLM. Animals were treated with GLPG1690 or vehicle.Whole superior right lung was used for RNA extraction. Full transcriptome analysis was performed using the Agilent SurePrint G3 mouse chip. Analysis was performed using empirical Bayes methods and linear models. Public human IPF expression data were re-analyzed. Results GLPG1690 strongly reduced lung fibrosis as shown by reduction of Ashcroft scores and collagen content. Microarray analysis of the lungs revealed that GLPG1690 strongly reversed the impact of gene expression caused by BLM (367 out of the 2375 probes). As GLPG1690 treatment affects 395 probes, this treatment effect is highly relevant in the model. Gene clusters affected by BLM treatment and reverted by GLPG1690 are related to extracellular matrix (such as Tnc and Spp1), collagen (Col3a1) and cytokines/chemokines (Cxcl12). Several of the affected genes are known to be involved in the development or progression of lung fibrosis in IPF patients. Conclusions These data provide further mechanistic understanding of the efficacy of ATX inhibition in a pre-clinical lung fibrosis model, highlighting a role for extracellular matrix and inflammation biology. These data strongly suggest that GLPG1690 may be beneficial in treating IPF patients and support its evaluation in a clinical study
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Maté Ongenaert
Guía Básica para tener en cuenta en trabajos donde abundan serpientes y representan un peligro al personal, en especial en los Proyectos en ejecución.
Ofidismo en el trabajo
Ofidismo en el trabajo
Javier Estigarribia Linares
Protección & Seguridad es una publicación especializada del Consejo Colombiano de Seguridad (CCS). Incluye artículos sobre seguridad industrial, salud ocupacional, incendios y emergencias, desastres naturales, security, protección ambiental, entre otros, elaborados por personal especializado en estas áreas de entidades nacionales e internacionales, previa aprobación del consejo editorial.
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Claudio Cesar Pontes ن
Classes Objetos Atributos Comportamentos
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Charles Fortes
By Umair Rasool Azmi. MNS University of Agriculture, Multan.
Maize production technology
Maize production technology
Umair Rasool Azmi
Nesta apresentação serão apresentados diferentes aspectos relacionados à design, manutenção segurança e performance, que influenciam a construção de ERP's com PHP. Boas práticas, Design Patterns, Facade, Adapter, Modelagem, DDD, Acoplamento, Sessões, Cache de objetos.
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Pablo Dall'Oglio
General Arabian Feb
General Arabian Feb
Joud Al-Kateb
Prof. Chin RL
Prof. Chin RL
Joud Al-Kateb
General Arabian May
General Arabian May
Joud Al-Kateb
Kreuz Apotheke Zeugnis
Kreuz Apotheke Zeugnis
Joud Al-Kateb
Bachelor Degree of Pharmacy
Bachelor Degree of Pharmacy
Joud Al-Kateb
MAS_Diploma
MAS_Diploma
Joud Al-Kateb
Mais conteúdo relacionado
Destaque
En el Siglo 21
La Informática Educativa y la Docencia Universitaria
La Informática Educativa y la Docencia Universitaria
Jorge Francisco Vera Mosquera
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF Maté Ongenaert (Mechelen, Belgium), Maté Ongenaert, Sonia Dupont, Roland Blanqué, Reginald Brys, Ellen van der Aar, Bertrand Heckmann ERS - European Respiratory Society International Congress 2016. Session: Therapeutic horizons: novel targets and pharmacological models Background and objectives GLPG1690 is a novel potent autotaxin (ATX) inhibitor shown to be efficacious in the mouse bleomycin (BLM) lung fibrosis model. Here, we analyze the impact of GLPG1690 on the gene expression signature in mouse fibrotic lung tissue. Methods Lung fibrosis was induced by intranasal administration of BLM. Animals were treated with GLPG1690 or vehicle.Whole superior right lung was used for RNA extraction. Full transcriptome analysis was performed using the Agilent SurePrint G3 mouse chip. Analysis was performed using empirical Bayes methods and linear models. Public human IPF expression data were re-analyzed. Results GLPG1690 strongly reduced lung fibrosis as shown by reduction of Ashcroft scores and collagen content. Microarray analysis of the lungs revealed that GLPG1690 strongly reversed the impact of gene expression caused by BLM (367 out of the 2375 probes). As GLPG1690 treatment affects 395 probes, this treatment effect is highly relevant in the model. Gene clusters affected by BLM treatment and reverted by GLPG1690 are related to extracellular matrix (such as Tnc and Spp1), collagen (Col3a1) and cytokines/chemokines (Cxcl12). Several of the affected genes are known to be involved in the development or progression of lung fibrosis in IPF patients. Conclusions These data provide further mechanistic understanding of the efficacy of ATX inhibition in a pre-clinical lung fibrosis model, highlighting a role for extracellular matrix and inflammation biology. These data strongly suggest that GLPG1690 may be beneficial in treating IPF patients and support its evaluation in a clinical study
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Maté Ongenaert
Guía Básica para tener en cuenta en trabajos donde abundan serpientes y representan un peligro al personal, en especial en los Proyectos en ejecución.
Ofidismo en el trabajo
Ofidismo en el trabajo
Javier Estigarribia Linares
Protección & Seguridad es una publicación especializada del Consejo Colombiano de Seguridad (CCS). Incluye artículos sobre seguridad industrial, salud ocupacional, incendios y emergencias, desastres naturales, security, protección ambiental, entre otros, elaborados por personal especializado en estas áreas de entidades nacionales e internacionales, previa aprobación del consejo editorial.
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Claudio Cesar Pontes ن
Classes Objetos Atributos Comportamentos
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Charles Fortes
By Umair Rasool Azmi. MNS University of Agriculture, Multan.
Maize production technology
Maize production technology
Umair Rasool Azmi
Nesta apresentação serão apresentados diferentes aspectos relacionados à design, manutenção segurança e performance, que influenciam a construção de ERP's com PHP. Boas práticas, Design Patterns, Facade, Adapter, Modelagem, DDD, Acoplamento, Sessões, Cache de objetos.
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Pablo Dall'Oglio
Destaque
(7)
La Informática Educativa y la Docencia Universitaria
La Informática Educativa y la Docencia Universitaria
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor...
Ofidismo en el trabajo
Ofidismo en el trabajo
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Revista Protección y Seguridad (Dezembro de 2016 Colombia)
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Pitagoras - Introdução a Programação Orientada a Objetos - Conceitos
Maize production technology
Maize production technology
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Construindo ERP's com PHP: Desafios em design, manutenção segurança e perf...
Mais de Joud Al-Kateb
General Arabian Feb
General Arabian Feb
Joud Al-Kateb
Prof. Chin RL
Prof. Chin RL
Joud Al-Kateb
General Arabian May
General Arabian May
Joud Al-Kateb
Kreuz Apotheke Zeugnis
Kreuz Apotheke Zeugnis
Joud Al-Kateb
Bachelor Degree of Pharmacy
Bachelor Degree of Pharmacy
Joud Al-Kateb
MAS_Diploma
MAS_Diploma
Joud Al-Kateb
Mais de Joud Al-Kateb
(6)
General Arabian Feb
General Arabian Feb
Prof. Chin RL
Prof. Chin RL
General Arabian May
General Arabian May
Kreuz Apotheke Zeugnis
Kreuz Apotheke Zeugnis
Bachelor Degree of Pharmacy
Bachelor Degree of Pharmacy
MAS_Diploma
MAS_Diploma
Novartis RL
1.
Scanned by CamScanner
Baixar agora
