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February 2010 Selected Zoonotic Diseases Conference Call
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In contrast to 2014, news on the Ebola virus today is relatively minimal. However, Ebola outbreaks are still occurring, most recently in the Democratic Republic of Congo. This article reviews the response of the U.S. FDA to the Ebola virus and programs that have encouraged the availability of investigational medical countermeasures, including vaccines and diagnostic tests...
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Data Con LA 2020 Description The Children's Hospital, Los Angeles (CHLA) COVID-19 Analysis Research Database (CARD) (https://covid19.cpmbiodev.net/) is a comprehensive genomic resource of SARS-CoV-2 viral genomes and associated meta-data of over 80,000 (as of August 13, 2020) isolates collected from global sequencing laboratories and the Center for Personalized Medicine (CPM) at CHLA. A Virus Genome Tracker accepts virus genome sequence and places the new viral isolate within the global or USA phylogenetic contexts based upon variant and haplotype comparisons to trace the transmission for genomic surveillance. By haplotype analysis of 4,200 California isolates, 6,356 USA isolates, and over 80,000 global isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. Phylogenetic analyses revealed the cryptic introduction of multiple SARS-CoV-2 lineages into California and Los Angeles, deriving from state-to-state transmission, and from international travel by air and ship. The majority of sequences Orange County isolates formed distinct outbreak clusters whose haplotypes were different from isolates of the neighboring Los Angeles. From the 50,000 global isolates, 22,171 (45.8%) isolates carried country-private haplotypes. The percentage were 28.2-29.6% in January to March, and rapidly increased to 46.4% and 59.6% in April and May, co-occurring with global travel restrictions. Speaker Lishuang Shen, Children's Hospital Los Angeles, Sr. Bioinformatics Scientist
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Background Influenza A viruses are medically significant pathogens responsible for higher mortality and morbidity throughout the world. Swine influenza is known to be caused by influenza A subtypes H1N1, H1N2, and H3N2, which are highly contagious, and belongs to the family Orthomyxoviridae. Efficient and accurate diagnosis of influenza A in individuals is critical for monitoring of a constantly evolving pandemic. A rapid result is important, because timely treatment can reduce disease severity and duration. Rapid antigen tests were among the first-line diagnostic tools for the detection of pandemic H1N1 (2009) virus infection during the initial outbreak. Current study focuses on the significant approach of the usage of molecular method utilizing real-time PCR for the detection of type A influenza virus (H1N1 subtype) in humans. Methods A total of 2000 mixed nasal/throat swab specimens collected in commercial viral transport from Apollo hospitals, Hyderabad were submitted to Institute of Preventive Medicine for molecular testing by reverse transcriptase polymerase chain reaction (RT-PCR) from 2009 to 2015 from its affiliated primary care clinics. Results Among the 2000 samples collected, 700 samples were positive for Human Inf A, swine Inf A, and Swine Inf H1 (fourth table in the article). One thousand two hundred samples were negative for Human Inf A, swine Inf A, and Swine Inf H1, and 100 samples were positive for Influenza A only. Conclusion The molecular testing of H1N1 patients helped the clinicians in timely diagnosis and treatment of these patients during the pandemic surveillance. The RT-PCR test has higher sensitivity and specificity; hence it is considered to be the best tool to use during the pandemic surveillance, as compared to the any other commercial antigen-based tests, which show a variable performance, with the sensitivities of tests from different manufacturers ranging from 9 to 77%.
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Data Con LA 2020 Description The Children's Hospital, Los Angeles (CHLA) COVID-19 Analysis Research Database (CARD) (https://covid19.cpmbiodev.net/) is a comprehensive genomic resource of SARS-CoV-2 viral genomes and associated meta-data of over 80,000 (as of August 13, 2020) isolates collected from global sequencing laboratories and the Center for Personalized Medicine (CPM) at CHLA. A Virus Genome Tracker accepts virus genome sequence and places the new viral isolate within the global or USA phylogenetic contexts based upon variant and haplotype comparisons to trace the transmission for genomic surveillance. By haplotype analysis of 4,200 California isolates, 6,356 USA isolates, and over 80,000 global isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. Phylogenetic analyses revealed the cryptic introduction of multiple SARS-CoV-2 lineages into California and Los Angeles, deriving from state-to-state transmission, and from international travel by air and ship. The majority of sequences Orange County isolates formed distinct outbreak clusters whose haplotypes were different from isolates of the neighboring Los Angeles. From the 50,000 global isolates, 22,171 (45.8%) isolates carried country-private haplotypes. The percentage were 28.2-29.6% in January to March, and rapidly increased to 46.4% and 59.6% in April and May, co-occurring with global travel restrictions. Speaker Lishuang Shen, Children's Hospital Los Angeles, Sr. Bioinformatics Scientist
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Background Influenza A viruses are medically significant pathogens responsible for higher mortality and morbidity throughout the world. Swine influenza is known to be caused by influenza A subtypes H1N1, H1N2, and H3N2, which are highly contagious, and belongs to the family Orthomyxoviridae. Efficient and accurate diagnosis of influenza A in individuals is critical for monitoring of a constantly evolving pandemic. A rapid result is important, because timely treatment can reduce disease severity and duration. Rapid antigen tests were among the first-line diagnostic tools for the detection of pandemic H1N1 (2009) virus infection during the initial outbreak. Current study focuses on the significant approach of the usage of molecular method utilizing real-time PCR for the detection of type A influenza virus (H1N1 subtype) in humans. Methods A total of 2000 mixed nasal/throat swab specimens collected in commercial viral transport from Apollo hospitals, Hyderabad were submitted to Institute of Preventive Medicine for molecular testing by reverse transcriptase polymerase chain reaction (RT-PCR) from 2009 to 2015 from its affiliated primary care clinics. Results Among the 2000 samples collected, 700 samples were positive for Human Inf A, swine Inf A, and Swine Inf H1 (fourth table in the article). One thousand two hundred samples were negative for Human Inf A, swine Inf A, and Swine Inf H1, and 100 samples were positive for Influenza A only. Conclusion The molecular testing of H1N1 patients helped the clinicians in timely diagnosis and treatment of these patients during the pandemic surveillance. The RT-PCR test has higher sensitivity and specificity; hence it is considered to be the best tool to use during the pandemic surveillance, as compared to the any other commercial antigen-based tests, which show a variable performance, with the sensitivities of tests from different manufacturers ranging from 9 to 77%.
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In the midst of a rapidly spreading global pandemic, real-world evidence can offer invaluable insight into the most promising treatments, risk factors, and not only predict but suggest how to improve outcomes. Despite overwhelming news coverage, significant knowledge gaps regarding COVID-19 persist. The current uncertainties regarding incidence and the case fatality rate can only be addressed by widespread testing. But the paucity of testing, and diversity of approaches implemented in different countries, particularly among the general asymptomatic public, perpetuates a lack of understanding about spread and infectivity. The essential indicators that would describe the pandemic more accurately can be obtained using real-world data (RWD). To that purpose, we designed a data collection tool to collect data from hospitals that treat COVID-19 patients. The captured data will enhance our understanding of the COVID-19 pandemic, identify risk factors relevant for triage, relate to other similar seasonal infections and gain insight into the safety and efficacy of experimental and off-label therapies. Knowledge derived from a focused data collection effort will enable clinicians to adjust rapidly clinical protocols and discontinue interventions that turn out to be ineffective or harmful. By deploying our elegantly designed survey to capture routine clinical indicators, we avoid placing an additional burden on practitioners. Systematically generating real-world evidence can decrease the time to insight compared to randomized clinical trials, improving the odds for patients in rapidly changing conditions.
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The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published. The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
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Malaria is still considered globally as a leading cause of morbidity with Nigeria carrying the highest burden of 19%. Coinfection of malaria and Human Immunodeficiency Virus (HIV) accelerate disease progression of HIV/AIDS subjects. This study investigated the prevalence and predictors of malaria among HIV infected subjects attending the antiretroviral therapy Clinic at Federal the Medical Centre, Keffi, Nigeria. After ethical clearance, 200 whole blood specimens were collected from patients who gave informed consent and completed a self-structured questionnaire. The specimens were examined for malarial parasite using rapid kits and microscopy. The overall prevalence of the infection was 78/200 (39.0%). The prevalence was higher in male (44.7%) than female (34.0%) subjects. Those subjects aged < 20 years (54.5), male gender (44.7%), non-formal education holders (61.5%), farmers (62.5%), stream water users (48.1%), those that lives in rural setting (43.6%), those that do not use Insecticides Treated Nets (ITNs) (39.4%) and swampy environment dwellers (41.7%) were identified predictors for malaria infection in the area. All the predictors studied did not show any statistically significant difference with the infection but some arithmetic difference exists (P > 0.05). The 39.0% prevalence of malaria in HIV infected subjects is a public health concern. Therefore, Public health surveillance and health education among HIV population should be advocated to help eradicate malaria comes 2030. Further study that will characterize the genes of the parasite should be carried out.
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download.ppt
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The value of real-world evidence for clinicians and clinical researchers in t...
Emerging infectious threats to the blood supply
Emerging infectious threats to the blood supply
HIV Epidemiology in the Prairies
HIV Epidemiology in the Prairies
CNS Iinfection dengue, Teaching Slides, Dr M D Mohire, Kolhapur, Maharashtra,...
CNS Iinfection dengue, Teaching Slides, Dr M D Mohire, Kolhapur, Maharashtra,...
G021201054057
G021201054057
Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an...
Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an...
The dynmics of covid 19 in africa compare to the rest of the world
The dynmics of covid 19 in africa compare to the rest of the world
Advisor Live: Zika virus disease – What you need to know
Advisor Live: Zika virus disease – What you need to know
Mais de GDPH
Mosquitoes of Georgia
Mosquitoes of Georgia
GDPH
History of pesticide use and integrated pest management.
The Smell of Malathion
The Smell of Malathion
GDPH
NPDES Update - 2013
NPDES Update - 2013
GDPH
The Future of Arboviral Surveillance in Georgia
The Future of Arboviral Surveillance in Georgia
GDPH
Bed Bugs in Schools
Bed Bugs in Schools
GDPH
Updated bed bug handbook for the Georgia Department of Public Health.
GDPH Bed Bug Handbook 2012
GDPH Bed Bug Handbook 2012
GDPH
NPDES Update 2012
NPDES Update 2012
GDPH
public health, things that bite
What bit me
What bit me
GDPH
GMCA
Pesticide Environmental Stewardship Program
Pesticide Environmental Stewardship Program
GDPH
Update on NPDES permit for Georgia Mosquito Control ProgramP
NPDES Update GMCA 2011
NPDES Update GMCA 2011
GDPH
History and practices of mosquito control in coastal Georgia.
Master Naturalist Mosquito Control
Master Naturalist Mosquito Control
GDPH
BedBugsLiceScabiesOhMy
BedBugsLiceScabiesOhMy
GDPH
GA NPDES Permit Information
GA NPDES Permit Information
GDPH
NPDES Permit and Mosquito Surveillance
NPDES Permit and Mosquito Surveillance
GDPH
Mosquito license training chap 3 4
Mosquito license training chap 3 4
GDPH
bed bug biology, surveillance, and control
Bed Bugs GPHA
Bed Bugs GPHA
GDPH
GA bed bugs
GA bed bugs
GDPH
1. bed bugs
1. bed bugs
GDPH
about the Georgia Mosquito Control Association
GMCA
GMCA
GDPH
Surveillance, Record Keeping, And Mapping
Surveillance, Record Keeping, And Mapping
GDPH
Mais de GDPH
(20)
Mosquitoes of Georgia
Mosquitoes of Georgia
The Smell of Malathion
The Smell of Malathion
NPDES Update - 2013
NPDES Update - 2013
The Future of Arboviral Surveillance in Georgia
The Future of Arboviral Surveillance in Georgia
Bed Bugs in Schools
Bed Bugs in Schools
GDPH Bed Bug Handbook 2012
GDPH Bed Bug Handbook 2012
NPDES Update 2012
NPDES Update 2012
What bit me
What bit me
Pesticide Environmental Stewardship Program
Pesticide Environmental Stewardship Program
NPDES Update GMCA 2011
NPDES Update GMCA 2011
Master Naturalist Mosquito Control
Master Naturalist Mosquito Control
BedBugsLiceScabiesOhMy
BedBugsLiceScabiesOhMy
GA NPDES Permit Information
GA NPDES Permit Information
NPDES Permit and Mosquito Surveillance
NPDES Permit and Mosquito Surveillance
Mosquito license training chap 3 4
Mosquito license training chap 3 4
Bed Bugs GPHA
Bed Bugs GPHA
GA bed bugs
GA bed bugs
1. bed bugs
1. bed bugs
GMCA
GMCA
Surveillance, Record Keeping, And Mapping
Surveillance, Record Keeping, And Mapping
Ga Arboviral Surveillance
1.
GEORGIA UPDATE 2009
Rosmarie Kelly Public Health Entomologist Georgia Division of Public Health
2.
3.
Human Arboviral Disease
Surveillance in Georgia Meghan Weems
4.
5.
6.
7.
8.
9.
10.
Veterinary Cases Georgia
Department of Agriculture Dr Rhonda Veit
11.
12.
13.
14.
15.
Detection of veterinary
cases indicates that the risk of human disease is increasing.
16.
Dead Bird Surveillance
GDPH and UGA/SCWDS
17.
18.
Where Are The
Birds?
19.
Mosquito Surveillance GDPH
and UGA/SCWDS
20.
21.
22.
23.
24.
25.
A cost-benefit analysis
indicated that only 15 cases of West Nile neuroinvasive disease would need to be prevented to make the emergency spray cost-effective.
26.
Emergency Mosquito Control
27.
Surveillance trailer
28.
29.
RESPONSE: Surveillance and
Control
30.
ANY QUESTIONS ?
Thanks to everyone involved in arboviral surveillance in Georgia.
Baixar agora