ScienceCloud: Collaborative Workflows in Biologics R&D
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The life sciences industry has undergone dramatic changes and effective global collaboration has become a key success factor in this new age. BIOVIA is providing a hosted and comprehensive solution stack for externalized, collaborative research for pharma/biotech and CROs to address these new challenges. Recently we added the support for biologics data management and IP capture. In this talk we will present collaborative and comprehensive capabilities in antibody characterization and development: capabilities to analyze, annotate and predict developability as part of a framework that facilitates secure data sharing and collaboration.
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ScienceCloud: Collaborative Workflows in Biologics R&D
- 1. 3DS.COM©DassaultSystèmes|ConfidentialInformation|3/5/2015|ref.:3DS_Document_2014 Mathew Hahn, Ph.D., Ton van Daelen, Ph.D. BIOVIA ScienceCloud: Collaborative Workflows in Biologics R&D
- 3. Industry Trends • Number of new drugs approved per billion US dollars spent on R&D has halved roughly every 9 years since 1950 • Average cost of bringing a new drug to market: $2.6B* Nature Reviews Drug Discovery 11, 191-200 (March 2012) * ‘Cost to Develop and Win Marketing Approval for a New Drug’ Joseph A. DiMasi, director of economic analysis at Tufts CSDD, 2014
- 4. Two Major Trends: Shift towards biologics Increased reliance on external collaborations
- 5. External Collaboration Challenges • Internal IT infrastructure not suitable for external projects • Work is manual and error prone • Starting up / closing down projects can take months • Every collaboration is different / not clear where to go
- 6. ScienceCloud • A suite of cloud-based integrated apps able to interface with on-prem systems to support networked scientific workflows for all shapes of external collaborations A AA Transfer, Translate, Transform A Data Documents Context Integrated Apps API Social Mobile Security IntegrationAdmin Business rules Tech transfer Automation
- 7. ScienceCloud Application Suite Tasks BTX. WorkbenchBioReg Notebook Project Data & Documents Analysis ExchangeAuthoring (Pipeline Pilot) Search (Insight) Inventory (CisPro) Screening
- 8. Challenges in Biologics Discovery Innovation Barriers • Lack of dedicated tools to: • process and understand high volume antibody sequence data, assay data and cell line data together • assess developability early in the process • rapidly customize workflows • Integrate, process and report on data through all phases of the discovery process • Lack of real time project tracking and collaboration with internal and external partners • Lack of biologically aware and integrated: • registration system • sample and assay management systems • ELN and corporate databases • bioprocess systems • process optimization systems • regulatory quality and compliance systems Process Efficiency Barriers
- 9. BIOVIA Suite for Antibody R&D Antibody R&D Analysis Biotherapeutics Workbench (BTx) Predictive Analytics Discovery Studio Custom Workflows Pipeline Pilot Entity Mgmt Registration and Sample Laboratory Management ELN & EKB Process Knowledge Discoverant Innovation Barriers Process Efficiency Barriers
- 10. External Collaboration with Biologics Notebook Registration 1. Receive biologic (antigen) from supplier 2. Register biologic 3. Share with external partner 4. Request synthesis of hybridoma clones 4. Synthesize biologic 5. Document experiment in ScienceCloud Notebook 6. Send notification to pharma 7. Pick up synthesized clones 8. Merge with assay data 9. Analyze in BTX workbench (annotate cluster) 10. Share and report BTX Workbench
- 11. Sign in to ScienceCloud
- 15. Automated Notification to Project Team
- 18. Partner: Analyze Clones Analyze Clones
- 19. Cluster Clones Using Assay Data
- 20. Save Most Promising Candidates
- 22. Wrap Up • Effective external collaboration is key success factor • Biologics functionality has matured and now available both on-prem and in the cloud • ton.vandaelen@3ds.com
- 23. Contact Info • Visit us on the web at www.sciencecloud.com • Find us on LinkedIn: • Join the ScienceCloud LinkedIn Group: ScienceCloud: Transforming Externalized Drug Discovery • Follow the BIOVIA page • To get in touch with a ScienceCloud team member, please click here
Notas do Editor
- I want to start out by stating a fact that I am sure you are well too aware of. the number of new drugs approved per billion dollars spent on R&D has halved roughly every 9 years since 1950. The cost of getting a drug to market is growing the curve here is adjusted for inflation and appears to be the opposite of the graphs we are used to seeing representing Moores law depicting the dramatic increase in the computer processing power,.
- Here’s just a quick overview of the Product Life Cycle for Discovery, Dev and manufacturing of biologics, Informatics needs are highlighted by t the arrows below. Today we are only going to talk about value we add in the biologics discovery space but keep in mind that the whole is much greater than the sum of its parts. and
- There are innovation barriers that include a lack of dedicated tools to: process and understand high volume antibody sequence data manage high volumes of sequence data, cell line data, analyse sequence annotation and activity data together assess developability early in the process rapidly customize workflows These barriers slow speed to market and cost organizations 100’S OF Millions of dollars for each year a drug is not on the market $30Mdollars a day (humira) There are also process efficiency barriers that include: a lack of real time project tracking and collaboration with various groups involved in the process a lack of biologically aware and integrated: Registration, sample management and bioprocess management systems Lab management ELN’s and corporate dB’s if you could: improve scientific insight and decision-making on promotion of biologic candidates reduce experiments performed, attributable to easy access to modeling and previous experimental data reduce time spent recording information for bioprocess experiments save time assembling relevant information for biologics portfolio review reduce effort required for technology transfer from research to development optimize bioprocess and manufacturing and easily maintain and process compliance documents for regulatory agencies.
- (This is the elevator pitch) If you are developing biologics and are faced with barriers to innovation and barriers to process efficiency we have a solution suite that can save you time and reduce cost associated with errors or lack of accessible information early in the process. The BIOVIA suite for biologics will allow you to: capture and render all relationships and structural information for novel biologics manage and mine all experimental, sample, and results data from bioprocess and cell line management processes integrate predictive modeling, characterization, and assay information for tracking the progress of your biologics portfolio And facilitate team decision making and collaboration with: project-level sharing of data, analysis results and reporting project-tracking dashboards And cloud and SaaS-based deployment options
- Business Issues in externalization: How can each participant in the project share the data they have generated with the sponsoring company and where appropriate between the partners in real time? How can each partners IP be tracked and ownership maintained? How can dynamic collaborations be spun up and down as needed to support a fast changing project landscape? What do I do when my internal IT systems can’t address these issues? Accelrys ScienceCloud addresses these issues, will cover in the next few slides. At a high level, ScienceCloud provides a platform for Information exchange, technology transfer, collaborative workspace, and hosted scientific data Initial vision is a suite of integrated applications which network of RD partners can use for collaborations, to facilitate better sharing and exchange of data and information This sharing takes place between “Applications” and partners. Many apps will still reside on prem, so we have capability to link on prem to cloud…internal and external sources are connected ScienceCloud Project Data is central collaboration core, applications surround it. This slide is a complete vision- through releases of a variety of applications, Accelrys ScienceCloud helps customers achieve this vision all at once, or a bit at a time.