Dr. Russell Waddell of Royal Adelaide Hospital
discusses the clinical presentation and treatment of syphilis in people with HIV. This presentation was given at AFAO's syphilis forum in May 2009.
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Russell Waddell: Syphilis Presentation and Treatment
1. Sexually Transmitted Diseases Services Dr. Russell Waddell Internal Medicine Service Royal Adelaide Hospital Syphilis Presentation Manifestations PLHIV Treatment
2. How Syphilis Causes Disease (Pathophysiology) Treponema pallidum penetrates intact mucous membranes or microscopic dermal abrasions and within hours enters lymphatics and blood to spread throughout the body. It attaches to the endothelial lining of blood vessels causing inflammation - endarteritis. Later there can be a hyper-sensitivity response to the organism resulting in gummatous lesions and necrosis
9. Secondary Syphilis – Condylomata Lata Source : Florida STD/HIV Prevention Training Center
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12. Clinical History of Syphilis 1 o 1- 6 weeks 2 o weeks to months 3 y Early latent Early latent Late latent 2 years Incubation 9 – 90 days Neuro syphilis Gumma Cardiovascular