A Presentation Given at the General Electric Whitney Symposium on Networks

1. Crowd-Sourcing to Build a Structure Centric Community for Chemists Antony Williams Whitney Symposium 2008 - Networks

2. Social Networking for Chemists

3. Network Drug Discovery Tools www.curehunter.com

4. Beware the Networks!

7. Collaborative Knowledge Management for Chemists – Wikipedia, Built by a Network

8. and biologists…WikiProteins

9. WikiProteins What Is Tegafur?

14. Tell me about Aspirin

15. Tell me about Aspirin

16. Links out to KEGG Kyoto Encyclopedia of Genes and Genomes

17. Tell me about Aspirin

18. Tell me About Aspirin

19. Tell me about Aspirin

20. Tell me about Aspirin

22. Example Search

23. Example Search

25. Example Search 2

26. Complex Search

27. Search Open Access Journals – ChemSpider

28. Search PubMed – ChemSpider

31. Quality is a Major Issue- Search Butanol

32. Crowd-sourcing Database Compilation

33. Wikipedia – Crowdsourcing Chemistry

36. Differences between ChemSpider/Wikipedia No Analytical Data Active editors – about 50 (?) Active depositors/curators – 30 No Prediction of properties ???? 5000 people/day; 1100 registered Detailed compound monographs Compound monographs linked Text Complex queries – Properties, Text, structure/substructure, OA publishers, Data Sources, … ~5000 organics, 2000 others >20 million unique structures Wikipedia ChemSpider

37. Differences between Wikipedia/ChemSpider Growing reputation as focused on quality Worldwide reputation as quality source Chemistry is the focus of ‘Spider Chemistry is a subset of the ‘Pedia Mixed “licensing” GFL licensing for everything Growing team of WP:Chem advocates, curators and admins Strong team of WP:Chem advocates, curators and admins “ Out of a basement” on three servers and 5 volunteers Established infrastructure and Wikipedia Foundation Team Primarily Microsoft .NET technologies with OS components Supported by tried and tested Media-Wiki platform. ChemSpider Wikipedia

39. Multi-level Curation and Approval

43. Adding to the Database - Structure

44. Adding New Text Data Add Publication Add Identifier Add URL

45. Adding Supplementary Info to a Structure

48. LASSO Ligand Activity by Surface Similarity Order

49. LASSO Descriptors on ChemSpider SEMANTIC WEB in action

54. ChemSpider TouchGraph