Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn Dressings Burn DressingsBurn Dressings Burn Dressings

1. Burn Dressings
19-12-05
Zohaib Hussain
1

2. Burn Wounds
Trends in biotechnology, 36(9), 907-922. 2

3. Ideal Burn Wound Dressing
3

4. Dressing based upon Wound Depth
and Exudates
4

5. Types of Polymeric Dressings
5

6. a. sodium alginate b. Chitosan c. Dextran d. N-O-carboxymethyl chitosan
e. Hydroxyethyl starch f. Glucan g. Hyaluronic acid h. Poly-N-acetylglucosamine
i. Silk j. Gelatin
Natural Polymers
6

7. a. polyvinyl alcohol
b. poly (N-isopropylacrylamide)
c. poly (N-vinylpyrrolidone)
d. polyethylene glycol
e. polyurethane)
Synthetic Polymers
7

8. Hydrocolloid Dressings
• The gel forming agents are combined with elastomers and adhesives
and applied to a carrier
• A variety of constituents including gelatin, pectin and sodium
carboxymethylcellulose in an adhesive polymer matrix.
• Forms a gel when their inner layer comes into contact with exudate
• Examples of a hydrocolloid dressing include Comfeel (Coloplast) and
DuoDerm (ConvaTec).
8

9. SMARTPORE Technology®
9

10. Comfeel® Plus
It consists of a semipermeable polyurethane film coated with a
flexible, cross-linked adhesive mass containing sodium
carboxymethylcellulose and calcium alginate
DuoDERM® Dressings
First to incorporate hydrocolloid technology
BETAplast®
It consists of polyurethane foam dressing impregnated with 3%
PVP-I, which has powerful antimicrobial properties
Medifoam®
A korea leading company in biomaterials especially wound
dressings 10

11. BETAplast®
11

12. Commercial Products
12

13. Polyurethane Films Based Dressings
• Polyurethane films are transparent, adhesive-coated sheets
• Permeable to water vapour, oxygen and carbon dioxide but
not to liquid water or bacteria.
• Film dressings are suitable for lightly exuding wounds
• OpSite (Smith & Nephew) or Tegaderm(3M Company),
Finesse PU Film,
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14. Polyurethanes
• Composed of urethane linkages in their main chains.
• Properties can be tuned-chemical structure, the molecular
weight of polyol, contents of hard and soft segment, or a
synthetic method.
• Fibers, elastomers, adhesives, coatings, synthetic leathers and
construction materials.
• Hydrophilic (PEG)
14

15. Hydrogel Dressings
• High water content gels containing insoluble polymers d by crosslinking of
polymers (PVA, PEO)
• Modified carboxymethylcellulose, hemicellulose, agar, glycerol and pectin.
• More capacity to absorb fluid-higher levels of wound exudate-Autolytic
debridement
• Amorphous form (a loose gel)
• such as IntraSite (Smith & Nephew) and Solugel,
• Sheet form where the gel is presented with a fixed three-dimensional macro
structure.
• Aqua clear and Nu-gel (Johnson & Johnson) 15

16. INTRASITE Gel
• Amorphous hydrogel-contains propylene glycol
• SOLUGEL™
Wound Care Gel is a clear hydrogel
• Purilon® gel
Consists of purified water, sodium carboxymethylcellulose, and
calcium alginate. Natural ingredients-No additives
16

17. Commercial Products
17

18. Alginate Dressings
• Calcium or sodium/calcium salts of alginate acid-seaweed
• Sodium salts present in the wound exchange with the calcium in the alginate
to form sodium alginate, a hydrophilic gel
• Ability to absorb exudate into itself while maintaining a moist environment.
• Highly absorbent, form gel with exudates, provide a moist interface, are
easily removed-Rinsed away with saline irrigation
• (Algisite M™, Sorbsan™, Algosteril (Johnson & Johnson), Comfeel Alginate
Dressing (Coloplast), Carrasorb H (Carrington Laboratories), Kaltostat
(ConvaTec), quacel®, Aquacel Extra® and Aquacel Foam®.
18

19. Commercial Products
19

20. Silk Fibroin
• Poor mechanical strength of collagen that restricts its applications
for wound dressings
• SF is a flexible polymer with excellent mechanical properties,
including tensile strength (0.5 GPa), breaking elongation (15%), and
elasticity (<35%)
• Cross-linked structure of elastin hinders its processability and
decreases its solubility. Additionally, available supplies of elastin are
more limited
• SF has high solubility in aqueous salt solutions
• nanofibers, sponges, films, and hydrogels.
• Synthetic polymers, such as soft silicon are not biodegradable,
Polyurethanes-toxicity of the degradation products
• SF is categorized as a non-degradable material based on the US
Pharmacopeia’s definition 20

21. Chouhan, D., Lohe, T. U., Samudrala, P. K., & Mandal, B. B. (2018). In situ forming injectable silk
fibroin hydrogel promotes skin regeneration in full thickness burn wounds. Advanced healthcare
materials, 7(24), 1801092.
Silk Fibroin
21

22. Foam Dressings
• Soft, open-celled hydrophobic/hydrophilic non-adherent dressings that may
be single or multiple layered and meet many of the properties of an ideal
dressing
• Exudry™ Zetuvit™ and Mesorb® are examples of products with a highly
absorbent pad and a non-stick, non-shear surface.
• As a secondary dressing over moderate to highly exudating wounds and over
hydrocolloid paste, cadexomer iodine, alginate and other primary dressings.
• Zetuvit E is a non-irritant absorbent dressing pad. The covering layer consists
of hydrophobic, non-woven polypropelene material.
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23. Nanofiber-based Wound Dressings
An electrospun-nanofibrous layer is applied to a basic support
fabric material
• Haemostasis
• High filtration & liquid absorption efficiency
• Semi-permeability: Facilitate cell respiration due to their porosity
• Conformability
• Functional ability
• Scar free
23

24. Commercial Products
24

25. Hydroactive Dressings
• Hydroactive dressings are multi-layered highly absorbent polymer
dressings with a surface adhesive and a waterproof outer layer are
similar to hydrocolloids, however, instead of forming a gel in
contact with exudate, the fluid is trapped within the product itself,
to maintain a moist environment.
• highly absorbent polymer dressings
• waterproof
• non-residual
• semi-permeable
Cutinova Hydro™, Tielle™, Biatain™Cavity dressing, PolyMem® 25

26. Conclusion
A wound dressing thus approaching ideal characteristics should
conform to the site of the wound, offer alleviation of pain
symptoms, promote faster wound-healing time and attempt to
restore the patients’ normal daily activities
The need for a more holistic approach towards wound healing and
management so that while selecting the appropriate dressing for a
wound, the physiological and biochemical requirement of the
wound and the patient are also taken into account.
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