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Yissum’s Mission

To promote the transfer of Hebrew University technology
for the benefit of society, while maximizing returns to
support research, education and scientific excellence




Yissum = Hebrew for ‘application’
The Technology Transfer Process
                                 Yissum protects the IP
                                 and commercializes it




                      HUJI
                  researchers
                                                             The Industry
                 discover new
                                                             partner pays
Research Money    invention &
                                                              Yissum for
                     submit
                                                            the license to
                   disclosure
                                                               use its IP




                                 Yissum pays royalties to
                                the researchers and HUJI
A Heritage of Excellence

                              43% of Israel’s
                              biotechnology       30% of all Israeli
           >1/3 of PhD           research         academic scientific
      students in Israel                          research

                                                      23,000 students
  1,000 researchers
    (staff members)
                                                       1,600 Post-Graduate
                                                       students in
                                                       biotechnology
5 affiliated hospitals
                                                      6 Campuses

       3,500 Research                              >100 Research
              projects
                                                   centers
                           Over 400 Researchers
                            in applied sciences
Areas of Expertise


     Pharmacology and
                          Agriculture
     Medicine


     Brain Research       Engineering and
                          Computer Science


     Nanoscience and
                          Cleantech
     Advanced Materials



     Education            Veterinary
48 Years of Transferring Technologies


                          7,736 patents
                         2,212 inventions
                           566 licenses
                           74 spin-offs




    Products based on Hebrew University technologies &
commercialized by Yissum generate over $2 billion in annual sales
Israel Tech Transfer Organization



                                               Yissum
                                                 40%
      Yeda
      21%

                                                             Yissum’s innovations
                         Yissum -                            reflect 40% of the total
                         a leading                           number of projects
                       member of the                         available for licensing
                           ITTN *
                                                             by Israeli technology
  Technion                                                   transfer companies.
    13%
                                                  Bar Ilan
                                                    5%

                                                  Ben
             Ramot    TLV                        Gurion
              8%                          Carmel
                     Medical   Mor Hadasit 1%     4%
                     Center    2%    5%
                       1%

* By number of available technologies
Intellectual Property


           Materials &                         2011 Snapshot
           Chemistry      Agriculture,           150 new inventions
              20%           Food &
                           Nutrition,
                                                 154 new patent
                          Cleantech              applications
                             14%                 54 new patents granted
                                Micro & Opto
                                Electronics
                A variety of        5%         Intellectual Property at HU
                   new           Computer
                                                 Yissum owns all IP
                inventions       Science &       developed at HU
                                Engeneering      Researchers receive
                                    11%
                                                 40-60% of revenues
     Life Science &
     Biotechnology
           50%
Projects Available for Licensing 2012


                       Materials &          Agriculture,
                     Nanotechnology           Food &
                          15%                Nutrition,
                                             Cleantech
                                                13%


                                                     Applied physics
                                                           4%

                               Over 400
                                                            Computer
                             technologies                   Science &
                                                           Engeneering
    Life Science &                                            13%
    Biotechnology
         53%                                          Education
                                                          1%
                                                Homeland
                                                 Security
                                                   1%
Yissum’s Biotech Product Pipeline:
                           Phase I   Phase II   Phase III
Vekacia ® (Novagali)
Cyclokat ® (Novagali)
Ladostigil, (Avraham)
BC819 (Biocancell)
Anti Angiogenic (Tiltan)
MRX4 (Morria)
MRX6 (Morria)
Acc. Levodopa (Intec)
Acc. Zalepon (Intec)
LABR-312 ( Biorest)
CatioProst ® (Novagali)
BL7040 (Bioline Rx)
AB103 (Atox Bio)
PRX105 (Protalix)
Apocell (Enlivex)
CCS/C (Nasvax)
EPOdure (Medgenics)
Protexia (Pharmathene)
Acc. Baclofen (Intec)
Cortiject ® (Novagali)
MM-002 (Moebius)
74 Spin-Off Companies Created Since 1964
Global Reach
Success Stories - Exelon




             Exelon®

             For Treatment of Symptoms Alzheimer’s Disease and
             Dementia
             Prof. Marta Weinstock-Rosin
             Department of Pharmacology, Faculty of Medicine
             The Hebrew University of Jerusalem
             2010 sales over $1 Billion
Success Stories - Doxil




              DOXIL® - Doxorubicin HCI liposome injection

              Alza’s Lead Product for Oncology
              Prof. Yechezkel Barenholz
              Department of Biochemistry, Faculty of Medicine
              The Hebrew University of Jerusalem
              Prof. Alberto Gabizon
              Hadassah University Hospital Jerusalem
              2010 sales over $500 million
Success Stories - Tomatoes




             Long Shelf Life Tomatoes

             The world’s most popular cocktail hybrids for year
             round greenhouse production
             Prof. Nachum Kedar
             Prof. Haim Rabinowich
             Department of Field Crops, Vegetables and Genetics:
             Faculty of Agriculture, Food and Environmental
             Sciences
             The Hebrew University Rehovot Campus
Success Stories - Peppers




             Hybrid Peppers
             Breeding of Blocky type pepper hybrids for growing under
             mild winter conditions. Market leader in Spain, Israel &
             Mexico In collaboration with Zeraim Gedera (Fully owned
             by Syngenta)
             Dr. Yonatan Elkind
             Department of Field Crops, Vegetables and Genetics:
             Faculty of Agriculture, Food and Environmental Sciences
             The Hebrew University Rehovot Campus
Success Stories - Mobileye




             Mobileye

              Advanced vision based driver assistance system for
              accident prevention
              Prof. Amnon Shashua
              Computer Science & Engineering, Faculty of Science
              The Hebrew University of Jerusalem
              2010 Valuation of $740 million
              (Investment by Goldman Sachs & others)
Products on the Market



The innovative cationic                           Periochip - slow drug
emulsion for the treatment                        release for periodentitis
of dry eye symptoms
                                                  Prof. Michael Friedman &
Prof. Simon Benita                                Prof. Doron Steinberg




                                                   Bioresorbable
Supra-Vir - Acyclovir cream for                    Adhesion Barrier
HSV topical treatment                              reduces the severity
                                  Moisturizing
                                                   of post-operative
Prof. Elka Touitou                Eye Drops
                                                   cardiac adhesions
                                  Prof. Shabtay
                                  Dikstein         Prof. Daniel Cohn

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Yissum May 2012

  • 1. Yissum’s Mission To promote the transfer of Hebrew University technology for the benefit of society, while maximizing returns to support research, education and scientific excellence Yissum = Hebrew for ‘application’
  • 2. The Technology Transfer Process Yissum protects the IP and commercializes it HUJI researchers The Industry discover new partner pays Research Money invention & Yissum for submit the license to disclosure use its IP Yissum pays royalties to the researchers and HUJI
  • 3. A Heritage of Excellence 43% of Israel’s biotechnology 30% of all Israeli >1/3 of PhD research academic scientific students in Israel research 23,000 students 1,000 researchers (staff members) 1,600 Post-Graduate students in biotechnology 5 affiliated hospitals 6 Campuses 3,500 Research >100 Research projects centers Over 400 Researchers in applied sciences
  • 4. Areas of Expertise Pharmacology and Agriculture Medicine Brain Research Engineering and Computer Science Nanoscience and Cleantech Advanced Materials Education Veterinary
  • 5. 48 Years of Transferring Technologies 7,736 patents 2,212 inventions 566 licenses 74 spin-offs Products based on Hebrew University technologies & commercialized by Yissum generate over $2 billion in annual sales
  • 6. Israel Tech Transfer Organization Yissum 40% Yeda 21% Yissum’s innovations Yissum - reflect 40% of the total a leading number of projects member of the available for licensing ITTN * by Israeli technology Technion transfer companies. 13% Bar Ilan 5% Ben Ramot TLV Gurion 8% Carmel Medical Mor Hadasit 1% 4% Center 2% 5% 1% * By number of available technologies
  • 7. Intellectual Property Materials & 2011 Snapshot Chemistry Agriculture, 150 new inventions 20% Food & Nutrition, 154 new patent Cleantech applications 14% 54 new patents granted Micro & Opto Electronics A variety of 5% Intellectual Property at HU new Computer Yissum owns all IP inventions Science & developed at HU Engeneering Researchers receive 11% 40-60% of revenues Life Science & Biotechnology 50%
  • 8. Projects Available for Licensing 2012 Materials & Agriculture, Nanotechnology Food & 15% Nutrition, Cleantech 13% Applied physics 4% Over 400 Computer technologies Science & Engeneering Life Science & 13% Biotechnology 53% Education 1% Homeland Security 1%
  • 9. Yissum’s Biotech Product Pipeline: Phase I Phase II Phase III Vekacia ® (Novagali) Cyclokat ® (Novagali) Ladostigil, (Avraham) BC819 (Biocancell) Anti Angiogenic (Tiltan) MRX4 (Morria) MRX6 (Morria) Acc. Levodopa (Intec) Acc. Zalepon (Intec) LABR-312 ( Biorest) CatioProst ® (Novagali) BL7040 (Bioline Rx) AB103 (Atox Bio) PRX105 (Protalix) Apocell (Enlivex) CCS/C (Nasvax) EPOdure (Medgenics) Protexia (Pharmathene) Acc. Baclofen (Intec) Cortiject ® (Novagali) MM-002 (Moebius)
  • 10. 74 Spin-Off Companies Created Since 1964
  • 12. Success Stories - Exelon Exelon® For Treatment of Symptoms Alzheimer’s Disease and Dementia Prof. Marta Weinstock-Rosin Department of Pharmacology, Faculty of Medicine The Hebrew University of Jerusalem 2010 sales over $1 Billion
  • 13. Success Stories - Doxil DOXIL® - Doxorubicin HCI liposome injection Alza’s Lead Product for Oncology Prof. Yechezkel Barenholz Department of Biochemistry, Faculty of Medicine The Hebrew University of Jerusalem Prof. Alberto Gabizon Hadassah University Hospital Jerusalem 2010 sales over $500 million
  • 14. Success Stories - Tomatoes Long Shelf Life Tomatoes The world’s most popular cocktail hybrids for year round greenhouse production Prof. Nachum Kedar Prof. Haim Rabinowich Department of Field Crops, Vegetables and Genetics: Faculty of Agriculture, Food and Environmental Sciences The Hebrew University Rehovot Campus
  • 15. Success Stories - Peppers Hybrid Peppers Breeding of Blocky type pepper hybrids for growing under mild winter conditions. Market leader in Spain, Israel & Mexico In collaboration with Zeraim Gedera (Fully owned by Syngenta) Dr. Yonatan Elkind Department of Field Crops, Vegetables and Genetics: Faculty of Agriculture, Food and Environmental Sciences The Hebrew University Rehovot Campus
  • 16. Success Stories - Mobileye Mobileye Advanced vision based driver assistance system for accident prevention Prof. Amnon Shashua Computer Science & Engineering, Faculty of Science The Hebrew University of Jerusalem 2010 Valuation of $740 million (Investment by Goldman Sachs & others)
  • 17. Products on the Market The innovative cationic Periochip - slow drug emulsion for the treatment release for periodentitis of dry eye symptoms Prof. Michael Friedman & Prof. Simon Benita Prof. Doron Steinberg Bioresorbable Supra-Vir - Acyclovir cream for Adhesion Barrier HSV topical treatment reduces the severity Moisturizing of post-operative Prof. Elka Touitou Eye Drops cardiac adhesions Prof. Shabtay Dikstein Prof. Daniel Cohn