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Cognito ergo sum.     Descartes     I think, therefore I am…!
CPC 4.2.3 ,[object Object],[object Object],[object Object],[object Object]
CPC 4.2.3 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CPC 4.2.3 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Investigations ,[object Object],[object Object],[object Object],[object Object],[object Object]
CPC 4.2.3 –Discuss D.D. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ Thought is Free & Powerful”  --William Shakespeare “Human mind is the  most powerful weapon in the world…!   - Osama bin laden…!
Pathology of Biliary Disorders Dr. Shashidhar Venkatesh Murthy Associate Prof. & Head of Pathology School of Medicine.
Anatomy:
Physiology: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Biliary Disorders: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholecystitis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute Cholecystitis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Cholecystitis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholesterosis : Strawberry GB. ,[object Object],[object Object],[object Object]
Cholesterolosis of gallbladder mucosa Cholesterol filled Foamy macrophages in mucosal folds
Complications of Cholecystitis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gallstone ileus
Cholelithiasis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Risk Factors: Cholelithiasis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholelithiasis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholelithiasis: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholelithiasis – Complications.
Gallstones + Chronic Cholecystitis ,[object Object],[object Object],[object Object],[object Object]
Cholecystitis & Gallstones ,[object Object],[object Object],[object Object]
Gallstones (mixed) Note: Yellowish shiny faceted stones, and thick inflammed gallbladder.
Pure Cholesterol Gallstones, bleeding. Round, yellow, spiky, bleeding.
Cholesterol Gallstones, bleeding. Round, yellow, spiky, bleeding. Note thickened inflammed gall bladder.
Cholesterol Gallstones.
Pigment stones in hemolytic anemia Note: Dark Black friable soft stones – Bilirubin
Gall stones in CBD Stones in CBD Stonees in GB 20% of mixed chol. stones and >50% of pigment stones are radio-opaque
Cholecystitis & Gallstones
“ What we think, we become”  --Buddha
Primary Biliary Cirrhosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Excess Bile - plugs Bile Obstruction leading to Cholestasis & Cholangitis Bile duct inflammation Bile staining
Cholestasis:  Bile “plugs”,  Bile “lakes” Bile Plugs Bile Lakes
Excess Bile Bile plug
PBC – Microscopy:
PBC – Microscopy:
PBC – Microscopy:
PBC – Microscopy:
Macronodular Cirrhosis - PBC
Macronodular Cirrhosis - PBC
Biliary Atresia in a 3m child. Dark bile stained liver tissue, cirrhosis & death before 2 years of age.
Neoplastic Disorders: (rare) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholangiocarcinoma: Gross Microscopy: Glands in desmoplastic (fibrous) stroma
“ Outer world is the reflection of our inner world  (thoughts) ”   --Baba
Carcinoma Gallbladder: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Carcinoma Gallbladder: Note irregular glandular structures and clusters of similar cells.
Carcinoma Bile duct: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Carcinoma Bile duct:
Adenocarcinoma: Normal Adeno Ca
Carcinoma Bile duct:
Great wars & Great creations start first in human mind…!    -- Thoughts are seeds with potential.
38y F, Obese, abdominal colicky pain, Gallbladder: ? Type of stones ,[object Object],[object Object],[object Object],[object Object],[object Object]
38y F, Obese, abdominal colicky pain, Gallbladder: ? Type of stones ,[object Object],[object Object],[object Object],[object Object],[object Object]
A 45y mildly obese woman, 1-week history of upper abdominal pain, fever, shaking chills, and occasional vomiting. Physical examination shows severe right upper quadrant tenderness. Laboratory studies include serum bilirubin of 1.0 mg/dL, AST of 25 U/L, ALT of 35 U/L, alkaline phosphatase of 220 U/L (high), WBC of 14,000/µL, and amylase of 95 U/L (normal). An ultrasound examination of the abdomen reveals a normal-appearing liver and bile duct and thickening of the wall of the gallbladder.  Most likely diagnosis?   ,[object Object],[object Object],[object Object],[object Object],[object Object]
40y Black woman, indigestion, abdominal pain, Gallbladder:  Most likely associated disease? ,[object Object],[object Object],[object Object],[object Object],[object Object]
69y M, Massive GI bleeding, jaundice.  Section of liver  ? Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
38y F, Obese, abdominal colicky pain, Gallbladder: ? Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
38y F, Obese, abdominal colicky pain, Gallbladder:  Most likely metabolic abnormality? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of Cholelithiasis include all the following  EXCEPT : ,[object Object],[object Object],[object Object],[object Object],[object Object]
62y F, Abd. Pain & jaundice. Gall bladder biopsy ? Diag ,[object Object],[object Object],[object Object],[object Object],[object Object]
38y F, jaundice. Gall bladder  ? Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
34y M, alcholic, mild icterus and malaise 6 months.  Liver biopsy.  ? diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
42y M, alcoholic, recurrent fatigue.  Liver biopsy.  ? Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
26y fem, medical student, day before pathology exam presents with mild scleral icterus. Physical Examination normal,  Liver function tests: Protein total-7.9, Albumin 4.8 g/dl, AST-36 U.L, ALT 16 U/L, ALP-36 U/L, Total Bilirubin 4.9, direct 0.7 mg/dl. Icterus resolves week later after exams.  Most likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Viral serology interpretation: ,[object Object],[object Object],[object Object],[object Object],[object Object],HBsAg  Positive,  Anti HBcAg  Positive Anti HBcAg IGM  Negative Anti HBsAg  Negative
CPC-2.3– C ore  L earning  I ssues : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ The ancestor of every action is a thought.”   --Ralph Waldo Emerson
34y M, alcoholic, homosexual- icterus and fever 6 months. Liver biopsy.  ? diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
34y M, icterus and fever.  Liver biopsy.  ? diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
56y chronic alcoholic, 2 days fever, abdomen distended, tender, tap yielded cloudy yellow fluid with 98% neutrophils, Blood culture E.coli. Patient dies 3 days later. Image shows his liver.  Most Likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
58y M, alcoholic, distended abdomen & icterus. Liver biopsy.  ? diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Viral serology interpretation: ,[object Object],[object Object],[object Object],[object Object],[object Object],HBsAg Negative,  Anti HBcAg Negative Anti HBcAg IGM Negative Anti HBsAg Positive
69y Female, Chronic bronchitis. Died following chronic Cardiac failure. Liver specimen.  Likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Viral serology interpretation: ,[object Object],[object Object],[object Object],[object Object],[object Object],HBsAg  Negative,  Anti HBsAg  Positive Anti HBcAg  Positive Anti HBcAg IGM Negative
59y Male, Alcoholic, presents with fatigue, anorexia. Normal liver function tests. Liver specimen.  Likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Histopathology Image is from lung biopsy of a 61 year male chronic smoker. What is the most likely type of carcinoma? ,[object Object],[object Object],[object Object],[object Object],[object Object]
The gross image of lung specimen from a 59year old male heavy smoker presented with high fever, shortness of breath.  Likely type of pneumonia?   ,[object Object],[object Object],[object Object],[object Object],[object Object]
42y male smoker presented with recurrent cough & dyspnoea. Image shows cut section of his lung.  What is the most likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
46 year male on treatment for lymphoma presents with pallor, shortness of breath and mild jaundice. Image shows his blood film appearance.  What is the most likely type of anemia? ,[object Object],[object Object],[object Object],[object Object],[object Object]
12 year old girl presents with two week history of fever and joint pain. The image shows her heart specimen.  What feature of the disease is shown by the arrow? ,[object Object],[object Object],[object Object],[object Object],[object Object]
78year female presents with prolonged weakness, fatigue and anemia. She has palpable spleen & few enlarged cervical  Lymphnodes. Image shows her blood film.  What is the most likely diagnosis? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Self Assessment is the key…! Whether new information is "stored" or "dumped" depends, then, on our  Interest , Reciting, Writing &  Reviewing  the information. Source:  http://www.web-us.com/memory/human_memory.htm   Retention of Learning Time Delay No review Review 7 Days 33% 83% 63 Days 14% 70%
Reminder…. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Living becomes a glorious experience only when there is tolerance and love. Willingness to compromise with other people’s ways of living and cooperation in common tasks, these make happy and successful societies. Divine Discourse, 17th February 1980 - Baba.   Love is Selfless Service.
5 A’s & SNAP  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Silence… To the question "Who am I?" the only relevant answer is silence. You need to discard all answers in words, including "I am Nothing" or "I am the Cosmic Self" or "I am the Self" - and just stick to the question "Who am I?". All other answers are just thoughts. Thoughts can never be complete. Only Silence is complete. Thoughts are not the goal in themselves. Their goal is Silence. When you ask the question "Who am I?" you get no answer, there is silence. That is the real answer. For your soul is solidified silence. This solidified silence is wisdom, is knowledge. The easy way to silence the thoughts is to arouse the feelings. For, through feelings only peace, joy and love dawn. And they are all your very nature. - Sri Sri Ravishankar

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Disorders of Biliary System

Notas do Editor

  1. A normal liver should NOT have this much bile pigment, in fact bile pigment in a normal liver biopsy should be scarce!
  2. Bile accumulations. Why does it look like a lot is BETWEEN hepatocytes in early stages?