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To predict and identify details regarding function from protein sequences is an emergency task since the growing number and diversity of protein s equence. Here, we develop a novel approach for identifying conservation residues and motifs of ligand-binding proteins. In this method, called MuLiSA (Multiple Ligand-bound Structure Alig nment), we first superimpose the ligands of ligand-binding proteins and then the residues of ligand-binding sites are naturally aligned. We identify important residues and patterns based o n the z-scores of the residue entropy and residue-segment entropy. After identifying new patt ern candidates, the profiles of patterns are generated to predict the protein function from only protein sequences. We tested our approach on ATP-binding proteins and HEM-binding proteins. T he experiments show that MuLiSA can identify the conservation residues and novel patter ns which are really correlated with protein functions of certain ligand-binding proteins. We fo und that our MuLiSA can identify conservation patterns and is better than traditiona l alignments such as CE and CLUSTALW in some ligand-binding proteins. We believe that our M uLiSA is useful to discover ligand-binding specificity-determining residues and functional imp ortant patterns of proteins.
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UVA Data Science Institute Master of Science in Data Science students Sean Mullane, Ruoyan Chen and Sri Vaishnavi Vemulapalli were motivated to apply data science tools and techniques to the problem, and see if protein structures can be quantitatively described, compared and otherwise analyzed in a more robust, efficient and automated manner. Potential applications include more effectively designed drugs to inhibit disease-related proteins, or even newly engineered ones. The researchers received the award for Best Paper in the Data Science for Health category at the 2019 Systems & Information Design Symposium (SIEDS) meeting. Their project, "Machine Learning for Classification of Protein Helix Capping Motifs," focused on small segments of a protein called secondary structural elements. These structural elements are the basic molecular-scale building blocks that all proteins—and therefore life—build upon.
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These are the slides delivered in a workshop at Data Innovation Summit Stockholm April 2024, by Kristof Neys and Jonas El Reweny.
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Neo4j
Sara Mae O’Brien Scott and Tatiana Baquero Cakici, Senior Consultants at Enterprise Knowledge (EK), presented “AI Fast Track to Search-Focused AI Solutions” at the Information Architecture Conference (IAC24) that took place on April 11, 2024 in Seattle, WA. In their presentation, O’Brien-Scott and Cakici focused on what Enterprise AI is, why it is important, and what it takes to empower organizations to get started on a search-based AI journey and stay on track. The presentation explored the complexities of enterprise search challenges and how IA principles can be leveraged to provide AI solutions through the use of a semantic layer. O’Brien-Scott and Cakici showcased a case study where a taxonomy, an ontology, and a knowledge graph were used to structure content at a healthcare workforce solutions organization, providing personalized content recommendations and increasing content findability. In this session, participants gained insights about the following: Most common types of AI categories and use cases; Recommended steps to design and implement taxonomies and ontologies, ensuring they evolve effectively and support the organization’s search objectives; Taxonomy and ontology design considerations and best practices; Real-world AI applications that illustrated the value of taxonomies, ontologies, and knowledge graphs; and Tools, roles, and skills to design and implement AI-powered search solutions.
IAC 2024 - IA Fast Track to Search Focused AI Solutions
IAC 2024 - IA Fast Track to Search Focused AI Solutions
Enterprise Knowledge
Cisco CCNA
CNv6 Instructor Chapter 6 Quality of Service
CNv6 Instructor Chapter 6 Quality of Service
giselly40
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
The Digital Insurer
Tech Trends Report 2024 Future Today Institute
Tech Trends Report 2024 Future Today Institute.pdf
Tech Trends Report 2024 Future Today Institute.pdf
hans926745
Partners Life - Insurer Innovation Award 2024
Partners Life - Insurer Innovation Award 2024
Partners Life - Insurer Innovation Award 2024
The Digital Insurer
This presentations targets students or working professionals. You may know Google for search, YouTube, Android, Chrome, and Gmail, but did you know Google has many developer tools, platforms & APIs? This comprehensive yet still high-level overview outlines the most impactful tools for where to run your code, store & analyze your data. It will also inspire you as to what's possible. This talk is 50 minutes in length.
Powerful Google developer tools for immediate impact! (2023-24 C)
Powerful Google developer tools for immediate impact! (2023-24 C)
wesley chun
Slides from the presentation on Machine Learning for the Arts & Humanities seminar at the University of Bologna (Digital Humanities and Digital Knowledge program)
Handwritten Text Recognition for manuscripts and early printed texts
Handwritten Text Recognition for manuscripts and early printed texts
Maria Levchenko
The Raspberry Pi 5 was announced on October 2023. This new version of the popular embedded device comes with a new iteration of Broadcom’s VideoCore GPU platform, and was released with a fully open source driver stack, developed by Igalia. The presentation will discuss some of the major changes required to support this new Video Core iteration, the challenges we faced in the process and the solutions we provided in order to deliver conformant OpenGL ES and Vulkan drivers. The talk will also cover the next steps for the open source Raspberry Pi 5 graphics stack. (c) Embedded Open Source Summit 2024 April 16-18, 2024 Seattle, Washington (US) https://events.linuxfoundation.org/embedded-open-source-summit/ https://eoss24.sched.com/event/1aBEx
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Igalia
45-60 minute session deck from introducing Google Apps Script to developers, IT leadership, and other technical professionals.
Automating Google Workspace (GWS) & more with Apps Script
Automating Google Workspace (GWS) & more with Apps Script
wesley chun
Copy of the slides presented by Matt Robison to the SFWelly Salesforce user group community on May 2 2024. The audience was truly international with attendees from at least 4 different countries joining online. Matt is an expert in data cloud and this was a brilliant session.
Data Cloud, More than a CDP by Matt Robison
Data Cloud, More than a CDP by Matt Robison
Anna Loughnan Colquhoun
Presented by Sergio Licea and John Hendershot
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
ThousandEyes
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Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
The Digital Insurer
writing some innovation for development and search
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdf
sudhanshuwaghmare1
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Scaling API-first – The story of a global engineering organization
Scaling API-first – The story of a global engineering organization
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
Strategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a Fresher
08448380779 Call Girls In Friends Colony Women Seeking Men
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08448380779 Call Girls In Civil Lines Women Seeking Men
08448380779 Call Girls In Civil Lines Women Seeking Men
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
IAC 2024 - IA Fast Track to Search Focused AI Solutions
IAC 2024 - IA Fast Track to Search Focused AI Solutions
CNv6 Instructor Chapter 6 Quality of Service
CNv6 Instructor Chapter 6 Quality of Service
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
Tech Trends Report 2024 Future Today Institute.pdf
Tech Trends Report 2024 Future Today Institute.pdf
Partners Life - Insurer Innovation Award 2024
Partners Life - Insurer Innovation Award 2024
Powerful Google developer tools for immediate impact! (2023-24 C)
Powerful Google developer tools for immediate impact! (2023-24 C)
Handwritten Text Recognition for manuscripts and early printed texts
Handwritten Text Recognition for manuscripts and early printed texts
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Automating Google Workspace (GWS) & more with Apps Script
Automating Google Workspace (GWS) & more with Apps Script
Data Cloud, More than a CDP by Matt Robison
Data Cloud, More than a CDP by Matt Robison
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
08448380779 Call Girls In Diplomatic Enclave Women Seeking Men
08448380779 Call Girls In Diplomatic Enclave Women Seeking Men
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdf
BEL110 presentation
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Protein tertiary and
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