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Differentiation of human embryonic stem cells



                                                     Mesoderm




                Ed Fridlander                        http://ahdc.vet.cornell.edu     http://training.fws.gov

                     Skeletal                         Erythrocytes                    Smooth Muscle
                     Muscle                                                               (Gut)


                                                     Ectoderm




                                http://www.biology                                  Yukiko Goda
                                ofhumanaging.com

                                      Epidermis                                    Neurons
hESC
                                                                                                Endoderm
                  http://flylib.com




                                                                                      http://www.sciencellonline.com

                              Alveolar Cells                                                        Hepatocytes        Hormone expressing islet
Differentiation of human embryonic stem cells – islet genesis



Human Embryonic
  Stem Cells      Endoderm                             Islet


                             Pancreatic   Endocrine
                             Progenitor   Progenitor
Differentiation of human embryonic stem cells - teratoma


             hESC      Endoderm      Islet




            Teratoma

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Stem Cell therapy for type 1 diabetes

  • 1. Differentiation of human embryonic stem cells Mesoderm Ed Fridlander http://ahdc.vet.cornell.edu http://training.fws.gov Skeletal Erythrocytes Smooth Muscle Muscle (Gut) Ectoderm http://www.biology Yukiko Goda ofhumanaging.com Epidermis Neurons hESC Endoderm http://flylib.com http://www.sciencellonline.com Alveolar Cells Hepatocytes Hormone expressing islet
  • 2. Differentiation of human embryonic stem cells – islet genesis Human Embryonic Stem Cells Endoderm Islet Pancreatic Endocrine Progenitor Progenitor
  • 3. Differentiation of human embryonic stem cells - teratoma hESC Endoderm Islet Teratoma