NỘI TIẾT

1. TỤY TẠNG NỘI TiẾT-ĐÁI
THÁO ĐƯỜNG-THUỐC DÙNG
TRONG ĐÁI THÁO ĐƯỜNG

2. TỤY TẠNG & INSULIN

3. INSULIN&GLUCAGON 2 THÀNH PHẦN PHẢN ĐiỀU HÒA

4. THỤ THỂ GLUCAGON

5. GLUCOSE TRANSPORTER


6. YẾU TỐ ĐiỀU BiẾN INSULIN

7. exendin-4

8. TASTE RECEPTOR IN INCRETINS SECRETION

9. INCRETINS
GIP, glucose-dependent insulinotropic
polypeptide; GLP-1, glucagon-like peptide-1.

10. PHYSIOLOGICAL ROLE OF INCRETINS
Physiology of GLP-1 secretion and action on GLP-1 receptors in different organs and tissues. GLP-1 is
produced postprandially by intestinal L-cells. Through activation of insulin receptors on beta-cells GLP-1
(like GIP) stimulates insulin biosynthesis and secretion and inhibits glucagon secretion in the pancreas,
which in turn reduces hepatic gluconeogenesis. GLP-1 release also exerts protective effects on heart and
brain. Insulin sensitivity in the periphery is increased by improved insulin signaling and reduced
gluconeogenesis. Figure modified with permission from Cell Metabolism [3]

11. PHYSIOLOGICAL ROLE OF INCRETINS

12. TÁC ĐỘNG CỦA GLP-1 TRÊN TẾ BÀO  ĐẢO TỤY

13. ADIPOSE TISSUE: FIRST MODULATOR

15. TẾ BÀO MỠ

16. DIABETES TYPE II: PATHOGENESIS
MODULATOR & TREATMENT WITH
SULFONYLUREAS-
THIAZOLIDINEDIONE-METFORMIN-
INCRETINS AGONISTS-DIPEPTIDYL
PEPTIDASE-4 INHIBITORS

17. INSULIN & BLOOD GLUCOSE

19. LỘ TRÌNH TÍN HiỆU CỦA INSULN

26. TZDs ACTIVATE PPARγ

27. THIAZOLIDINEDIONE GÂY PHÓNG THÍCH
INSULIN QUA CHOLESTEROL EFFLUX

28. TZDs INDUCED OSTEOPOROSIS

29. GLP-1 & AGONISTS

31. AMPK TARGET OF METFORMIN
+

32. AMPK NHIBITED Acetyl-CoA Carboxylase

33. ROLE OF METFORMIN IN CARDIAC PROTECTION
GLUT: Glucose transporter; PFK,
phosphofructokinase; ACC, Acetyl-CoA carboxylase;
CPT1, carnitine palmitoyltransferase 1; and MCD,
malonyl-CoA decarboxylase.

34. CẢM ƠN SỰ QUAN TÂM THEO DÕI