Sirdalud (Tizanidine) is a muscle relaxant which helps to relax certain muscles in your body. It relieves the painful muscle spasms related to the static and functional disorders of the spine or following certain surgeries such as herniated intervertebral disc or osteoarthritis of the hip. It is also used to treat spasticity due to neurological disorders such as multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.

1. Sirdalud Tablets
Sirdalud (Tizanidine) is a muscle
relaxant which helps to relax certain
muscles in your body. Sirdalud is
available in tablets containing 2 mg, 4 mg
or 6 mg Tizanidine Hydrochloride.
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2. Sirdalud Tablets
Indications
It relieves the painful muscle spasms related
to the static and functional disorders of the
spine or following certain surgeries such as
herniated intervertebral disc or osteoarthritis
of the hip.
It is also used to treat spasticity due to
neurological disorders such as multiple
sclerosis, chronic myelopathy, degenerative
spinal cord diseases, cerebrovascular
accidents, and cerebral palsy.
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3. Sirdalud Tablets
Chemical Structure
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4. Sirdalud Tablets
Recommended Adult Dosage
The Recommended dosage of
Sirdalud Tablets for various
indications is given below:
Painful muscle spasms:
2 to 4 mg three times daily.
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5. Sirdalud Tablets
Recommended Adult Dosage
Spasticity due to neurological
disorders:
The maximum initial recommended
dosage is 6 mg/day in 3 divided doses.
The dosage is then increased stepwise
to achieve optimum therapeutic
response (generally between 12 to 24
mg/day). The maximum daily dose is
36 mg which should not be exceeded.
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6. Sirdalud Tablets
Missed Dose
If you miss a dose, take it as soon as
you remember.
However, if you remember when it is
almost time for your next dose, take
only your usual dose at that time.
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7. Sirdalud Tablets
Contraindications
Sirdalud Tablets are contraindicated
in the following cases:
➔Known hypersensitivity to Tizanidine
Hydrochloride or any inactive ingredients
of this medication.
➔Significantly impaired hepatic function.
➔Concomitant use with strong CYP1A2
inhibitors such as fluvoxamine or
ciprofloxacin.
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8. Sirdalud Tablets
Side Effects of Sirdalud Tablets
With low doses, such as those
recommended for the relief of painful
muscle spasms the reported side effects
were somnolence, fatigue, asthenia,
dizziness, dry mouth, nausea,
gastrointestinal disorder, transaminase
increase, increased spasm or tone,
blood pressure decrease.
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9. Sirdalud Tablets
Side Effects of Sirdalud Tablets
With the higher doses, as recommended
for the treatment of spasticity, muscular
weakness, insomnia, sleep disorder,
hallucination, hypotension, bradycardia,
hepatitis and hepatic failure have also
been reported in addition to the side
effects for lower doses.
© The Swiss Pharmacy, Geneva Switzerland

10. Sirdalud Tablets
Warnings And Precautions
➔Co-administration of Sirdalud with inhibitors of
CYP1A2 such as some antiarrhythmics (amiodarone,
mexiletine, propafenone), cimetidine, some
fluoroquinolones (enoxacin, pefloxacin, norfloxacin),
rofecoxib, oral contraceptives and ticlopidine is not
recommended.
➔Hypotension may occur with potential severe
symptoms such as loss of consciousness and
circulatory collapse.
➔Gradual reduction in dosage is recommended to
avoid withdrawal syndrome.
➔Caution is advised in patients with impaired kidney
function.
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11. Sirdalud Tablets
Warnings And Precautions
➔Refrain from driving a vehicle or using
machines if dizziness or hypotension
occurs.
➔Use during pregnancy only if benefit
clearly outweighs the risk.
➔Avoid breastfeeding.
➔Use in children not recommended and
caution in elderly patients.
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12. Sirdalud Tablets
Overdosage Symptoms
A decrease in sensorium was
observed in the majority of cases that
included lethargy, somnolence,
confusion and coma. Depressed
cardiac functions are also observed
including most often bradycardia and
hypotension. Respiratory depression is
another common feature of tizanidine
overdose.
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13. Sirdalud Tablets
Overdose Treatment
Should overdose occur, basic steps to
ensure the adequacy of an airway
and the monitoring of cardiovascular
and respiratory systems should be
undertaken. Symptoms should
usually resolve within one to three
days following discontinuation of
tizanidine and administration of
appropriate therapy.
© The Swiss Pharmacy, Geneva Switzerland

14. Sirdalud Tablets
Sirdalud Tablets 2 mg
Manufactured by Novartis India
For more information click here
© The Swiss Pharmacy, Geneva Switzerland