Rifagut Tablets (Rifaximin) is an antibacterial used for the treatment of travelers diarrhea (TD). It is also used for reduction in risk of overt hepatic encephalopathy (HE) recurrence in patients.

1. Rifagut Tablets
Rifagut is an antibacterial used for the
treatment of travelers' diarrhea (TD) caused
by noninvasive strains of Escherichia coli in
patients 12 years of age and older. It is also
used for reduction in risk of overt hepatic
encephalopathy (HE) recurrence in patients 18
years of age and older. The active ingedient
present in Rifagut tablets is Rifaximin.
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2. Rifagut Tablets
Indications
Rifagut Tablets is an antibacterial. Rifagut
Tablets should be used only to treat or prevent
infections that are proven or strongly suspected
to be caused by bacteria.
Rifagut 200 mg is indicated for the treatment of
travelers' diarrhea (TD) caused by non-invasive
strains of Escherichia coli in patients
12 years of age and older.
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3. Rifagut Tablets
Indications
Rifagut Tablets (Rifaximin) should not be
used in patients with diarrhea
complicated by fever or blood in the stool
or diarrhea due to pathogens other than
Escherichia coli.
It is also used for reduction in risk of
overt hepatic encephalopathy (HE)
recurrence in patients 18 years of age
and older.
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4. Rifagut Tablets
Chemical Structure
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5. Rifagut Tablets
Active Ingredient
The active pharmaceutical ingredient
contained in Rifagut Tablets is
Rifaximin. Rifaximin is a semisynthetic
antibiotic based on Rifamycin.
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6. Rifagut Tablets
Recommended Dosage
The recommended dosage of Rifaximin for the
treatment of various indications is given below:
➔Travelers’ Diarrhea: The recommended dose of
Rifagut is one 200 mg tablet taken orally three
times a day for 3 days. Rifagut can be administered
orally, with or without food.
➔Hepatic Encephalopathy: The recommended
dose of Rifagut (Rifaximin) is one 550 mg tablet
taken orally two times a day, with or without food.
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7. Rifagut Tablets
Contraindications
Rifagut (Rifaximin Tablets) is contraindicated
in patients with the following conditions:
➔Hypersensitivity to Rifaximin, or any inactive
component of this medication.
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8. Rifagut Tablets
Side Effects of Rifagut Tablets
The most common side effects of Rifagut
Tablets in the treatment of Travelers’ Diarrhea
with an incidence rate of 5% or more Flatulence,
headache, abdominal pain, rectal tenesmus,
defecation urgency and nausea.
Most common side effects of Rifaximin (Rifagut
Tablets) in the treatment of Hepatic
Encephalopathy with an incidence rate of 10%
or more are Peripheral edema, nausea,
dizziness, fatigue, ascites, flatulence, and
headache.
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9. Rifagut Tablets
Warnings And Precautions
➔Travelers' Diarrhea Not Caused by Escherichia coli:
Rifagut was not found to be effective in patients with
diarrhea complicated by fever and/or blood in the stool or
diarrhea due to pathogens other than Escherichia coli.
Rifagut has to be discontinued if diarrhea symptoms get
worse or persist for more than 24 to 48 hours and
alternative antibiotic therapy should be considered.
➔Rifagut is not effective in cases of travelers’ diarrhea due
to Campylobacter jejuni. The effectiveness of Rifagut in
travelers’ diarrhea caused by Shigella spp. and Salmonella
spp. has not been proven. Rifagut should not be used in
patients where Campylobacter jejuni, Shigella spp., or
Salmonella spp. may be suspected as causative
pathogens.
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10. Rifagut Tablets
Warnings And Precautions
➔Clostridium difficile-Associated Diarrhea:
Clostridium difficile-associated diarrhea (CDAD) has
been reported with use of nearly all antibacterial
agents, including Rifagut, and may range in severity
from mild diarrhea to fatal colitis. Treatment with
antibacterial agents alters the normal flora of the
colon which may lead to overgrowth of C. difficile.
➔Development of Drug Resistant Bacteria:
Prescribing Rifagut for travelers’ diarrhea in the
absence of a proven or strongly suspected bacterial
infection or a prophylactic indication is unlikely to
provide benefit to the patient and increases the risk of
the development of drug-resistant bacteria.
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11. Rifagut Tablets
Warnings And Precautions
➔Severe (Child-Pugh C) Hepatic Impairment: There is
increased systemic exposure in patients with severe
hepatic impairment. Therefore, caution should be
exercised when administering Rifaximin (Rifagut
Tablets) to patients with severe hepatic impairment
(Child-Pugh C).
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12. Rifagut Tablets
Overdose Symptoms
No specific information is available on the treatment
of overdosage with Rifaximin (Rifagut Tablets). In
clinical studies at doses higher than the
recommended dose (more than 600 mg/day for
travelers’ diarrhea or more than 1100 mg/day for
hepatic encephalopathy), adverse reactions were
similar in patients who received doses higher than
the recommended dose and placebo.
In the case of overdosage, discontinue Rifaximin,
treat symptomatically, and institute supportive
measures as required.
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13. Rifagut Tablets
Rifagut Tablets from Sun Pharmaceutical
Industries Ltd., India
For more information click here
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