This document discusses normal and abnormal development of the female genital tract. It begins with an overview of embryology, including how genetic sex is determined at fertilization and how the indifferent gonad develops into either an ovary or testis. It then focuses on ovarian development and function. It describes several congenital uterine anomalies and their clinical presentations and treatment approaches. It also discusses Mullerian agenesis, vaginal agenesis, transverse vaginal septum, and imperforated hymen.
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Normal and Abnormal Development of the Female Genital Tract
1. Normal And Abnormal
Development Of Female
Genital Tract
Khalid Sait
FRCSC
Prof Gynecologist Oncologist
Faculty of Medicine
King Abdulaziz University
2. Embryology
n Baby sex established at the time of
fertilization ( sperm meet ovum )
n sperm 46 xy ovum 46 xx
(23x + 23 y) (23 x + 23 x)
Girl Boy
3. Gonadal sex
Testes / Ovaries
Genetic sex
XX / XY
Internal
genitalia
Hormones
External
genitalia
4. Embryology
n Gonads appear as genital ridges by proliferation of
coalemic epithelium(mesoderm)
n Primordal germ cell appear in the endodermal cell in the
wall of yolk sac , migrate along the mesentery of hindgut
and invade the genital ridges
n At 7 weeks the gonads of embryo:
indistinguishable male and female
( indifferent gonad)
n At 8 weeks if xx ----- Ovary
xy------- Testis
5. Embryology
Ovary
n Gonadal ovary : medullary cord degenerate and cortical cord
develop
n Germ cells ----oogonia
n 11-12 w : onset of oogenesis
n 20 w : 7 million germ cells in each ovary
n Birth : 2 millions
n Puberty : 40,000 primary oocytes remaining in the ovaries.
Only 400 ------------- secondary
oocytes and extended at ovulation once every month during menst.
Cycle.
n Descend of ovary is not an active migration, but result of rapid
growth of body and failure of gubernaculum to elongatee ( that why
its maintain blood supply from the aorta
22. Congenital Uterine Anomaly
n Treatment:
1- Double uterus (didelphic uterus): no need to treat.
2- Bicornate ut. --------- Strassmann procedure
( if indicated )
3- Ut. Septum --------- (BCP for dysmenorrhea ),
Tompkins metroplasty or Hysteroscopic resection of
septum )
4- Unicornate ut. -------- Surgery indicated if there is
blind horn which cause symptom----- surgical resection
of blind horn.
23. Mullerian Agenesis
n Mayer Custer Hauser Rokitansky Syndrome
n 1: 4000
n Abscent upper vagina, cervix and uterus and
tubes
n Normal ovaries and vulva
n Associated with spine and renal anomaly
n Treatment:
McIndoe procedure
Self dilatation of vagina
24.
25.
26. Vaginal Agenesis
n 1: 5000
n Normal Vulva
n Ass. With spine, renal and middle ear anomaly
n Treatment:
Karyotype, U/S - MRI ( only 5 % will have normal
functioning uterus)
Once patient sexually active
1- Gradual vaginal dilatation against vaginal dimple
(daily for 20-30 mint for few month with gradual dilators
size.
2- William procedure
3- Wharton and Macindo procedure
27. Transverse Vaginal Septum
n Mid vagina usually
n May be partial or complete
n Presentation:
Primary amenorrhea
Dysparonia
n Treatment:
Surgical resection
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32. Adult Equivalents of Embryonic Structures
FemaleEmbryonic Structure
ovaryIndifferent gonad
ovarian folliclesCortex
rete ovariiMedulla
ovarian and round ligament of uterusGubernaculum
epoophoron, paroophoronMesonephric tubules
appendix vesiculosa, duct of epoophoron, duct of Gartner,
ureter, pelvis, calices and collecting tubules
Mesonephric Duct
hydatid of Morgagni, uterine tube, uterusParamesonephric Duct
urinary bladder, urethra, vagina,
urethral, paraurethral and greater vestibular glands
Urogenital Sinus
hymenSinus tubercle
clitorisPhallus
labia minoraUrogenital folds
labia majoraLabioscrotal swellings