This document discusses methods for testing chromosomes in embryos, including preimplantation genetic screening (PGS). It notes that chromosome abnormalities are common in oocytes and increase with maternal age. Older techniques for PGS had limitations but new methods like microarray-based comparative genomic hybridization (CGH) allow analysis of all chromosomes and overcome many of the issues of prior techniques. Studies using CGH show reductions in aneuploidy and miscarriage rates as well as increased implantation and pregnancy rates. Gene expression analysis may also provide information about embryo viability beyond just detecting chromosome abnormalities.