Directed Readings Project for completion of Masters Degree from SDSU

1. The Heat Shock Protein Response in the Skeletal Muscle of Untrained Individuals Shaun Guest San Diego State University School of Exercise and Nutritional Sciences December 1st, 2009

2. Modified from Noble, 2008

3. INTRODUCTION Magnitude of heat shock response to exercise: Individual characteristics Training status Age Sex Absolute workload Intensity Duration Novelty of exercise stress Noble, 2008

4. INTRODUCTION Exercise training with trained individuals: Maximum volume workloads induces the largest HSP changes (Liu, 1999). Highest levels of HSP with high intensities (Liu 1999, 2000). High-intensity resistance exercise and low-intensity endurance exercise Blunted/abolished stress responses (Nething, 2003). HSP response due to increased baseline levels of HSPs pre-exercise (Morton, 2009).

5. PURPOSE Based on results from acute exercise bouts and training programs, determine whether exercise training in untrained individuals will lead to an attenuated heat shock protein response.

6. FINDING THE LITERATURE Data base search: PubMed/Medline (via EBSCO) Biosis Previews SPORTDiscus Web of Science Google Scholar Search topics: Heat shock proteins HSP72 Skeletal Muscle PEDro Scale. Quality of Evidence Score of 5 (Maher et al, 2003) Inclusion criteria: Male subjects Avg Age: 18-35 yrs Exclusion criteria: Female subjects Age > 35 yrs Musculoskeletal abnormality Neurologic disease

12. DISCUSSION With exercise training: Number of physiological adaptations in human skeletal muscle. Ex:  fat oxidation, LA, muscle remodeling The magnitude of the heat shock response is dependent upon: Individual characteristics Exercise Type Frequency Intensity Duration

13. CONCLUSIONS Based on results from acute exercise bouts and training programs, it remains unclear whether exercise training will lead to an attenuated response in untrained individuals. HSP response shown to be vary greatly between individuals. HSP results reflect genetic variability of skeletal muscle to recover, remodel, and/or adapt to exercise specific stress.

14. FUTURE RESEARCH Examine of role of HSP induction with performance. Continue to use non-damaging exercise protocols  ‘clean’ results. Compare HSP response with training program in untrained and trained individuals.

15. Questions???