SlideShare uma empresa Scribd logo
1 de 26
OPTIMIZATION TECHNIQUES
Suraj C.
AACP
2
PPT. Package
Concept Of Optimization
Optimization Parameters
Classical Optimization
Statistical Design
Simulation & Search
3
INTRODUCTION
4
INTRODUCTION
5
• In development projects , one generally
experiments by :
 a series of logical steps,
 carefully controlling the variables &
 changing one at a time, until a satisfactory
system is obtained
• It is not a screening technique.
IDEA !
6
OPTIMIZATION TECHNIQUES
Parametric
Non-
Parametric
Factorial
Central
Composite
Mixture
Lagrangian
Multiple
Regression
Fractional
Factorial
Plackett-
Burman
Evolutionary
methods
EVOP REVOP
CLASSICAL OPTIMIZATION
7
• Involves application of calculus to basic
problem for maximum/minimum function.
• One factor at a time (OFAT).
• Restrict attention to one factor at a time.
• Not more than 2 variables.
CLASSICAL OPTIMIZATION
8
• Using calculus the graph obtained can be solved.
Y = f (x)
• When the relation for the response y is given as the
function of two independent variables,X1 & X2
Y = f(X1 , X2)
• The above function is represented by contour plots on
which the axes represents the independent variables X1&
X2
Contd…..
CLASSICAL OPTIMIZATION
9
Response
Variable
Independent
Variable
Contd…..
CLASSICAL OPTIMIZATION
10
Independent
Variable - X2
Independent
Variable - X1
Contd…..
OFAT vs DOE
11
Properties OFAT DOE
Type Classical- Sequenctial one
one factor method
Scientific – simultaneous
with multiple factor
method
No. of experiments High – Decided by
experimenter
Limited – Selected by
design
Conclusion Inconclusive – Interaction
Interaction unknown
Comprehensive –
Interactions studied too.
Precision & Efficiency Poor – sometimes
misleading result with
errors (4 exp.)
High – Errors are shared
evenly (2 exp.)
Consequences One exp. Wrong… all goes
goes wrong -Inconclusive
Orthogoanl design –
Predictable & conclusive
Information gained Less per experiment High per experiment
STATISTICAL DESIGN
12
• Techniques used divided in to two types:
1. Experimentation continues as optimization
proceeds
2. Experimentation is completed before
optimization takes place.
STATISTICAL DESIGN
13
• Experimentation is completed before
optimization takes place.
 Theoretical approach
 Empirical or experimental approach
Contd…..
STATISTICAL TERMS
14
• Relationship with single independent variable -
Simple regression analysis or Least squares method.
• Relationship with more than one important variable -
Statistical design of experiment & Multi linear
regression analysis.
• Most widely used experimental plan is Factorial
design.
STATISTICAL DESIGN
15
• Optimization: helpful in shortening the experimenting
time.
• DOE: is a structured , organized method used to
determine the relationship between –
 the factors affecting a process &
 the output of that process.
• Statistical DOE: planning process + appropriate data
collected + analysed statistically.
Contd…..
MATHEMATICAL MODELS
16
• Permits the interpretation of RESPONSES more
economically & becomes less ambiguous.
1. First Order: 2 Levels of the factor – Linear
 LCL (Lower control limit) - {-ve or -1}
 UCL (Upper control limit) - {+ve or +1}
2. Second Order: 3 Levels (Mid-level) – coded as “0” –
Curvature effect
FIRST ORDER
17
X1
Response
LOW HIGH
Predictable Response at X1
SECOND ORDER
18
X1
Response
LOW HIGH
True Response
SIMULATION & SEARCH
METHODS
19
• Search method does not requires CONTINUITY or
DIFFERENTIALITY function.
• Search methods also known as - “Sequential
optimization”.
NOTE: Simulation involves the computability of a
response.
SIMULATION & SEARCH
METHODS
20
• A simple inspection of experimental results is
sufficient to choose the desired product.
• If the independent variable is Qualitative – Visual
observation is enough.
• Computer aid not required, but if it there then added
advantage.
• Even 5 variables can be handled at once.
Contd…..
SIMULATION & SEARCH
(types)
21
 Steepest Ascent Method
 Response Surface Methodology (RSM)
 Contour Plots
Steepest Ascent Method
22
• Procedure for moving sequentially along the path
(or direction) in order to obtain max. ↑ in response.
• Applied to analyze the responses obtained from:
1. Factorial Designs
2. Fractional Factorial Designs
NOTE: Initial estimates of DOE are far from actual, so
method chosen for optimum value.
Response Surface Methodology (RSM)
23
• A 3-D geometric representation that establishes an
empirical relationship between responses &
independent variables.
• For:
 Determining changes in response surface
 Determining optimal set of experimental
conditions
NOTE: Overlap of plots for complete info is possible.
Contour Plots
24
• Are 2-D (X1 & X2) graphs in which some variables are
held at one desired level & specific response noted.
• Both axes are in experimental units.
• Sometimes both the contour & RSM plots are drawn
together for better optimum values.
Contour Plots
25
RSM & Contour
Combined
26

Mais conteúdo relacionado

Mais procurados

Dissolution f1 and f2 Analysis and IVIVC
Dissolution f1 and f2 Analysis and IVIVCDissolution f1 and f2 Analysis and IVIVC
Dissolution f1 and f2 Analysis and IVIVCCipla Pharmaceuticals
 
Medical & Healthcare Products Regulatory Agency (MHRA)
Medical & Healthcare Products Regulatory Agency (MHRA)Medical & Healthcare Products Regulatory Agency (MHRA)
Medical & Healthcare Products Regulatory Agency (MHRA)PriyalBagwe
 
Current Good Manufacturing Practices(cGMP) and industrial management
Current Good Manufacturing Practices(cGMP) and industrial managementCurrent Good Manufacturing Practices(cGMP) and industrial management
Current Good Manufacturing Practices(cGMP) and industrial managementMahewash Sana Pathan
 
ICH Guideline Q8 Pharmaceutical Development
ICH Guideline Q8  Pharmaceutical DevelopmentICH Guideline Q8  Pharmaceutical Development
ICH Guideline Q8 Pharmaceutical DevelopmentBINDIYA PATEL
 
Study of consolidation parameters
Study of consolidation parametersStudy of consolidation parameters
Study of consolidation parametersDurga Bhavani
 
analytical method validation
analytical method validationanalytical method validation
analytical method validationDr. Raja Abhilash
 
permeability in vivo in vitro in situ.pptx
permeability in vivo in vitro in situ.pptxpermeability in vivo in vitro in situ.pptx
permeability in vivo in vitro in situ.pptxanumalagundam sreekanth
 
API, BIOLOGICS,NOVEL,THERAPIES........pptx
API, BIOLOGICS,NOVEL,THERAPIES........pptxAPI, BIOLOGICS,NOVEL,THERAPIES........pptx
API, BIOLOGICS,NOVEL,THERAPIES........pptxPawanDhamala1
 
Regulatory requirement of EU, MHRA and TGA
Regulatory requirement of EU, MHRA and TGARegulatory requirement of EU, MHRA and TGA
Regulatory requirement of EU, MHRA and TGAHimal Barakoti
 
Validation and calibration master plan
Validation and calibration master planValidation and calibration master plan
Validation and calibration master planBharatlal Sain
 
Dissolution profile comparison
Dissolution profile comparisonDissolution profile comparison
Dissolution profile comparisonMohammad Imran
 
Hippa new requirement to clinical study processes
Hippa new requirement to clinical study processesHippa new requirement to clinical study processes
Hippa new requirement to clinical study processesKavya S
 
Investigational medical product dossier
Investigational medical product dossierInvestigational medical product dossier
Investigational medical product dossierSachinFartade
 
Evaluation of transdermal drug delivery system
Evaluation of transdermal drug delivery systemEvaluation of transdermal drug delivery system
Evaluation of transdermal drug delivery systemSagar Savale
 

Mais procurados (20)

Dissolution f1 and f2 Analysis and IVIVC
Dissolution f1 and f2 Analysis and IVIVCDissolution f1 and f2 Analysis and IVIVC
Dissolution f1 and f2 Analysis and IVIVC
 
Medical & Healthcare Products Regulatory Agency (MHRA)
Medical & Healthcare Products Regulatory Agency (MHRA)Medical & Healthcare Products Regulatory Agency (MHRA)
Medical & Healthcare Products Regulatory Agency (MHRA)
 
Quality by Design ( QbD )
Quality by Design ( QbD )Quality by Design ( QbD )
Quality by Design ( QbD )
 
Current Good Manufacturing Practices(cGMP) and industrial management
Current Good Manufacturing Practices(cGMP) and industrial managementCurrent Good Manufacturing Practices(cGMP) and industrial management
Current Good Manufacturing Practices(cGMP) and industrial management
 
201p
201p201p
201p
 
ICH Guideline Q8 Pharmaceutical Development
ICH Guideline Q8  Pharmaceutical DevelopmentICH Guideline Q8  Pharmaceutical Development
ICH Guideline Q8 Pharmaceutical Development
 
Study of consolidation parameters
Study of consolidation parametersStudy of consolidation parameters
Study of consolidation parameters
 
analytical method validation
analytical method validationanalytical method validation
analytical method validation
 
Novel excipients
Novel excipientsNovel excipients
Novel excipients
 
permeability in vivo in vitro in situ.pptx
permeability in vivo in vitro in situ.pptxpermeability in vivo in vitro in situ.pptx
permeability in vivo in vitro in situ.pptx
 
API, BIOLOGICS,NOVEL,THERAPIES........pptx
API, BIOLOGICS,NOVEL,THERAPIES........pptxAPI, BIOLOGICS,NOVEL,THERAPIES........pptx
API, BIOLOGICS,NOVEL,THERAPIES........pptx
 
ICH Q8 Guidline
ICH Q8 GuidlineICH Q8 Guidline
ICH Q8 Guidline
 
Regulatory requirement of EU, MHRA and TGA
Regulatory requirement of EU, MHRA and TGARegulatory requirement of EU, MHRA and TGA
Regulatory requirement of EU, MHRA and TGA
 
Validation and calibration master plan
Validation and calibration master planValidation and calibration master plan
Validation and calibration master plan
 
Outsourcing BA and BE to CRO
Outsourcing BA and BE to CROOutsourcing BA and BE to CRO
Outsourcing BA and BE to CRO
 
Quality-by-Design in Pharmaceutical Development
Quality-by-Design in Pharmaceutical Development Quality-by-Design in Pharmaceutical Development
Quality-by-Design in Pharmaceutical Development
 
Dissolution profile comparison
Dissolution profile comparisonDissolution profile comparison
Dissolution profile comparison
 
Hippa new requirement to clinical study processes
Hippa new requirement to clinical study processesHippa new requirement to clinical study processes
Hippa new requirement to clinical study processes
 
Investigational medical product dossier
Investigational medical product dossierInvestigational medical product dossier
Investigational medical product dossier
 
Evaluation of transdermal drug delivery system
Evaluation of transdermal drug delivery systemEvaluation of transdermal drug delivery system
Evaluation of transdermal drug delivery system
 

Semelhante a Optimization in QBD

various applied optimization techniques and their role in pharmaceutical scie...
various applied optimization techniques and their role in pharmaceutical scie...various applied optimization techniques and their role in pharmaceutical scie...
various applied optimization techniques and their role in pharmaceutical scie...aakankshagupta07
 
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSINGOPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSINGcoollife99
 
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCES
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCESOPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCES
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCESprasad_bsreegiri
 
optimization in pharmaceutical formulations
optimization in pharmaceutical formulationsoptimization in pharmaceutical formulations
optimization in pharmaceutical formulationsShaik Naaz
 
4 26 2013 1 IME 674 Quality Assurance Reliability EXAM TERM PROJECT INFO...
4 26 2013 1 IME 674  Quality Assurance   Reliability EXAM   TERM PROJECT INFO...4 26 2013 1 IME 674  Quality Assurance   Reliability EXAM   TERM PROJECT INFO...
4 26 2013 1 IME 674 Quality Assurance Reliability EXAM TERM PROJECT INFO...Robin Beregovska
 
OPTIMIZATION tamjl.pptx
OPTIMIZATION tamjl.pptxOPTIMIZATION tamjl.pptx
OPTIMIZATION tamjl.pptxManojKumarr75
 
Experimental Design for Distributed Machine Learning with Myles Baker
Experimental Design for Distributed Machine Learning with Myles BakerExperimental Design for Distributed Machine Learning with Myles Baker
Experimental Design for Distributed Machine Learning with Myles BakerDatabricks
 
design of experiments.ppt
design of experiments.pptdesign of experiments.ppt
design of experiments.ppt9814857865
 
Design of experiments
Design of experimentsDesign of experiments
Design of experiments9814857865
 
Statistical Process Control
Statistical Process ControlStatistical Process Control
Statistical Process ControlTushar Naik
 
Optimization Techniques In Pharmaceutical Formulation & Processing
Optimization Techniques In Pharmaceutical Formulation & ProcessingOptimization Techniques In Pharmaceutical Formulation & Processing
Optimization Techniques In Pharmaceutical Formulation & ProcessingAPCER Life Sciences
 
variableselectionmodelBuilding.ppt
variableselectionmodelBuilding.pptvariableselectionmodelBuilding.ppt
variableselectionmodelBuilding.pptrajalakshmi5921
 

Semelhante a Optimization in QBD (20)

various applied optimization techniques and their role in pharmaceutical scie...
various applied optimization techniques and their role in pharmaceutical scie...various applied optimization techniques and their role in pharmaceutical scie...
various applied optimization techniques and their role in pharmaceutical scie...
 
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSINGOPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING
 
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCES
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCESOPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCES
OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL SCIENCES
 
optimization in pharmaceutical formulations
optimization in pharmaceutical formulationsoptimization in pharmaceutical formulations
optimization in pharmaceutical formulations
 
4 26 2013 1 IME 674 Quality Assurance Reliability EXAM TERM PROJECT INFO...
4 26 2013 1 IME 674  Quality Assurance   Reliability EXAM   TERM PROJECT INFO...4 26 2013 1 IME 674  Quality Assurance   Reliability EXAM   TERM PROJECT INFO...
4 26 2013 1 IME 674 Quality Assurance Reliability EXAM TERM PROJECT INFO...
 
Optimization final
Optimization finalOptimization final
Optimization final
 
Optimization
OptimizationOptimization
Optimization
 
OPTIMIZATION tamjl.pptx
OPTIMIZATION tamjl.pptxOPTIMIZATION tamjl.pptx
OPTIMIZATION tamjl.pptx
 
Experimental Design for Distributed Machine Learning with Myles Baker
Experimental Design for Distributed Machine Learning with Myles BakerExperimental Design for Distributed Machine Learning with Myles Baker
Experimental Design for Distributed Machine Learning with Myles Baker
 
design of experiments.ppt
design of experiments.pptdesign of experiments.ppt
design of experiments.ppt
 
Design of experiments
Design of experimentsDesign of experiments
Design of experiments
 
Spc
SpcSpc
Spc
 
Statistical Process Control
Statistical Process ControlStatistical Process Control
Statistical Process Control
 
G
GG
G
 
Biostatistics ppt.pptx
Biostatistics ppt.pptxBiostatistics ppt.pptx
Biostatistics ppt.pptx
 
Optimisation technique
Optimisation techniqueOptimisation technique
Optimisation technique
 
Optimization Techniques In Pharmaceutical Formulation & Processing
Optimization Techniques In Pharmaceutical Formulation & ProcessingOptimization Techniques In Pharmaceutical Formulation & Processing
Optimization Techniques In Pharmaceutical Formulation & Processing
 
variableselectionmodelBuilding.ppt
variableselectionmodelBuilding.pptvariableselectionmodelBuilding.ppt
variableselectionmodelBuilding.ppt
 
Optimization techniques
Optimization techniquesOptimization techniques
Optimization techniques
 
100018718.ppt
100018718.ppt100018718.ppt
100018718.ppt
 

Mais de Suraj Choudhary

Polymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug DeliveryPolymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug DeliverySuraj Choudhary
 
Vaginal Drug Delievery systems, - A writeup
Vaginal Drug Delievery systems, - A writeupVaginal Drug Delievery systems, - A writeup
Vaginal Drug Delievery systems, - A writeupSuraj Choudhary
 
Effect of Parameters - Controlled Drug Delivery Systems
Effect of Parameters - Controlled Drug Delivery SystemsEffect of Parameters - Controlled Drug Delivery Systems
Effect of Parameters - Controlled Drug Delivery SystemsSuraj Choudhary
 
Nano-Toxicology - An introduction
Nano-Toxicology - An introductionNano-Toxicology - An introduction
Nano-Toxicology - An introductionSuraj Choudhary
 
Ionizaion Techniques - Mass Spectroscopy
Ionizaion Techniques - Mass SpectroscopyIonizaion Techniques - Mass Spectroscopy
Ionizaion Techniques - Mass SpectroscopySuraj Choudhary
 
Activation Controlled drug Delivery System
Activation Controlled drug Delivery SystemActivation Controlled drug Delivery System
Activation Controlled drug Delivery SystemSuraj Choudhary
 
Rate Controlled Drug Delivery Systems (CRDDS)
Rate Controlled Drug Delivery Systems (CRDDS)Rate Controlled Drug Delivery Systems (CRDDS)
Rate Controlled Drug Delivery Systems (CRDDS)Suraj Choudhary
 
Chemical Shifts - Nuclear Magnetic Resonance (NMR)
Chemical Shifts - Nuclear Magnetic Resonance (NMR)Chemical Shifts - Nuclear Magnetic Resonance (NMR)
Chemical Shifts - Nuclear Magnetic Resonance (NMR)Suraj Choudhary
 
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...Suraj Choudhary
 
Transdermal Drug Delivery Systems - A writeup
Transdermal Drug Delivery Systems - A writeupTransdermal Drug Delivery Systems - A writeup
Transdermal Drug Delivery Systems - A writeupSuraj Choudhary
 
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)Suraj Choudhary
 
controlled Release Drug Delievery Systems - An introduction (writeup)
controlled Release Drug Delievery Systems - An introduction (writeup)controlled Release Drug Delievery Systems - An introduction (writeup)
controlled Release Drug Delievery Systems - An introduction (writeup)Suraj Choudhary
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
 
Controlled Release Drug Delivery Systems - An Introduction
Controlled Release Drug Delivery Systems - An IntroductionControlled Release Drug Delivery Systems - An Introduction
Controlled Release Drug Delivery Systems - An IntroductionSuraj Choudhary
 
Physicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsPhysicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsSuraj Choudhary
 
Solid Dispersion - Solubility enhancing tool
Solid Dispersion - Solubility enhancing toolSolid Dispersion - Solubility enhancing tool
Solid Dispersion - Solubility enhancing toolSuraj Choudhary
 
Effect of compression on tablet strength
Effect of compression on tablet strengthEffect of compression on tablet strength
Effect of compression on tablet strengthSuraj Choudhary
 
Drug excipient Compatibility
Drug excipient CompatibilityDrug excipient Compatibility
Drug excipient CompatibilitySuraj Choudhary
 
Compaction in Tablet Manufacturing
Compaction in Tablet ManufacturingCompaction in Tablet Manufacturing
Compaction in Tablet ManufacturingSuraj Choudhary
 

Mais de Suraj Choudhary (20)

Polymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug DeliveryPolymers - Mucoadhesive Drug Delivery
Polymers - Mucoadhesive Drug Delivery
 
Vaginal Drug Delievery systems, - A writeup
Vaginal Drug Delievery systems, - A writeupVaginal Drug Delievery systems, - A writeup
Vaginal Drug Delievery systems, - A writeup
 
Effect of Parameters - Controlled Drug Delivery Systems
Effect of Parameters - Controlled Drug Delivery SystemsEffect of Parameters - Controlled Drug Delivery Systems
Effect of Parameters - Controlled Drug Delivery Systems
 
Nano-Toxicology - An introduction
Nano-Toxicology - An introductionNano-Toxicology - An introduction
Nano-Toxicology - An introduction
 
Ionizaion Techniques - Mass Spectroscopy
Ionizaion Techniques - Mass SpectroscopyIonizaion Techniques - Mass Spectroscopy
Ionizaion Techniques - Mass Spectroscopy
 
Activation Controlled drug Delivery System
Activation Controlled drug Delivery SystemActivation Controlled drug Delivery System
Activation Controlled drug Delivery System
 
Rate Controlled Drug Delivery Systems (CRDDS)
Rate Controlled Drug Delivery Systems (CRDDS)Rate Controlled Drug Delivery Systems (CRDDS)
Rate Controlled Drug Delivery Systems (CRDDS)
 
Chemical Shifts - Nuclear Magnetic Resonance (NMR)
Chemical Shifts - Nuclear Magnetic Resonance (NMR)Chemical Shifts - Nuclear Magnetic Resonance (NMR)
Chemical Shifts - Nuclear Magnetic Resonance (NMR)
 
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...
Transdermal Drug Delivery Systems - (Physical enhancers through the skin) - A...
 
Transdermal Drug Delivery Systems - A writeup
Transdermal Drug Delivery Systems - A writeupTransdermal Drug Delivery Systems - A writeup
Transdermal Drug Delivery Systems - A writeup
 
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
Factors affecting design of Controlled Release Drug Delivery Systems (write-up)
 
controlled Release Drug Delievery Systems - An introduction (writeup)
controlled Release Drug Delievery Systems - An introduction (writeup)controlled Release Drug Delievery Systems - An introduction (writeup)
controlled Release Drug Delievery Systems - An introduction (writeup)
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and Applications
 
Controlled Release Drug Delivery Systems - An Introduction
Controlled Release Drug Delivery Systems - An IntroductionControlled Release Drug Delivery Systems - An Introduction
Controlled Release Drug Delivery Systems - An Introduction
 
Physicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of DrugsPhysicochemical Properties effect on Absorption of Drugs
Physicochemical Properties effect on Absorption of Drugs
 
Solid Dispersion - Solubility enhancing tool
Solid Dispersion - Solubility enhancing toolSolid Dispersion - Solubility enhancing tool
Solid Dispersion - Solubility enhancing tool
 
Effect of compression on tablet strength
Effect of compression on tablet strengthEffect of compression on tablet strength
Effect of compression on tablet strength
 
Drug excipient Compatibility
Drug excipient CompatibilityDrug excipient Compatibility
Drug excipient Compatibility
 
Compaction in Tablet Manufacturing
Compaction in Tablet ManufacturingCompaction in Tablet Manufacturing
Compaction in Tablet Manufacturing
 
FTIR vs Dispersive IR
FTIR vs Dispersive IRFTIR vs Dispersive IR
FTIR vs Dispersive IR
 

Último

Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...chennailover
 
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...hotbabesbook
 
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Availableperfect solution
 
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Hosur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service AvailableGENUINE ESCORT AGENCY
 
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...khalifaescort01
 
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service Available
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service AvailableTrichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service Available
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service AvailableGENUINE ESCORT AGENCY
 
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋TANUJA PANDEY
 
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...Arohi Goyal
 
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...adilkhan87451
 
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...tanya dube
 
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...chandars293
 
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service AvailableGENUINE ESCORT AGENCY
 
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...parulsinha
 
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...GENUINE ESCORT AGENCY
 
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...parulsinha
 
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service AvailableGENUINE ESCORT AGENCY
 
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...chennailover
 

Último (20)

Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
 
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
Night 7k to 12k Chennai City Center Call Girls 👉👉 7427069034⭐⭐ 100% Genuine E...
 
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
 
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Hosur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Hosur Just Call 9630942363 Top Class Call Girl Service Available
 
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
💕SONAM KUMAR💕Premium Call Girls Jaipur ↘️9257276172 ↙️One Night Stand With Lo...
 
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
 
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service Available
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service AvailableTrichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service Available
Trichy Call Girls Book Now 9630942363 Top Class Trichy Escort Service Available
 
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
 
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
All Time Service Available Call Girls Marine Drive 📳 9820252231 For 18+ VIP C...
 
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...
Russian Call Girls Lucknow Just Call 👉👉7877925207 Top Class Call Girl Service...
 
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 8250077686 Top Class Call Girl Service Available
 
🌹Attapur⬅️ Vip Call Girls Hyderabad 📱9352852248 Book Well Trand Call Girls In...
🌹Attapur⬅️ Vip Call Girls Hyderabad 📱9352852248 Book Well Trand Call Girls In...🌹Attapur⬅️ Vip Call Girls Hyderabad 📱9352852248 Book Well Trand Call Girls In...
🌹Attapur⬅️ Vip Call Girls Hyderabad 📱9352852248 Book Well Trand Call Girls In...
 
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
 
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
 
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
 
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
Premium Call Girls In Jaipur {8445551418} ❤️VVIP SEEMA Call Girl in Jaipur Ra...
 
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...
Models Call Girls In Hyderabad 9630942363 Hyderabad Call Girl & Hyderabad Esc...
 
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
 
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
 
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
 

Optimization in QBD

  • 2. 2 PPT. Package Concept Of Optimization Optimization Parameters Classical Optimization Statistical Design Simulation & Search
  • 5. 5 • In development projects , one generally experiments by :  a series of logical steps,  carefully controlling the variables &  changing one at a time, until a satisfactory system is obtained • It is not a screening technique. IDEA !
  • 7. CLASSICAL OPTIMIZATION 7 • Involves application of calculus to basic problem for maximum/minimum function. • One factor at a time (OFAT). • Restrict attention to one factor at a time. • Not more than 2 variables.
  • 8. CLASSICAL OPTIMIZATION 8 • Using calculus the graph obtained can be solved. Y = f (x) • When the relation for the response y is given as the function of two independent variables,X1 & X2 Y = f(X1 , X2) • The above function is represented by contour plots on which the axes represents the independent variables X1& X2 Contd…..
  • 10. CLASSICAL OPTIMIZATION 10 Independent Variable - X2 Independent Variable - X1 Contd…..
  • 11. OFAT vs DOE 11 Properties OFAT DOE Type Classical- Sequenctial one one factor method Scientific – simultaneous with multiple factor method No. of experiments High – Decided by experimenter Limited – Selected by design Conclusion Inconclusive – Interaction Interaction unknown Comprehensive – Interactions studied too. Precision & Efficiency Poor – sometimes misleading result with errors (4 exp.) High – Errors are shared evenly (2 exp.) Consequences One exp. Wrong… all goes goes wrong -Inconclusive Orthogoanl design – Predictable & conclusive Information gained Less per experiment High per experiment
  • 12. STATISTICAL DESIGN 12 • Techniques used divided in to two types: 1. Experimentation continues as optimization proceeds 2. Experimentation is completed before optimization takes place.
  • 13. STATISTICAL DESIGN 13 • Experimentation is completed before optimization takes place.  Theoretical approach  Empirical or experimental approach Contd…..
  • 14. STATISTICAL TERMS 14 • Relationship with single independent variable - Simple regression analysis or Least squares method. • Relationship with more than one important variable - Statistical design of experiment & Multi linear regression analysis. • Most widely used experimental plan is Factorial design.
  • 15. STATISTICAL DESIGN 15 • Optimization: helpful in shortening the experimenting time. • DOE: is a structured , organized method used to determine the relationship between –  the factors affecting a process &  the output of that process. • Statistical DOE: planning process + appropriate data collected + analysed statistically. Contd…..
  • 16. MATHEMATICAL MODELS 16 • Permits the interpretation of RESPONSES more economically & becomes less ambiguous. 1. First Order: 2 Levels of the factor – Linear  LCL (Lower control limit) - {-ve or -1}  UCL (Upper control limit) - {+ve or +1} 2. Second Order: 3 Levels (Mid-level) – coded as “0” – Curvature effect
  • 19. SIMULATION & SEARCH METHODS 19 • Search method does not requires CONTINUITY or DIFFERENTIALITY function. • Search methods also known as - “Sequential optimization”. NOTE: Simulation involves the computability of a response.
  • 20. SIMULATION & SEARCH METHODS 20 • A simple inspection of experimental results is sufficient to choose the desired product. • If the independent variable is Qualitative – Visual observation is enough. • Computer aid not required, but if it there then added advantage. • Even 5 variables can be handled at once. Contd…..
  • 21. SIMULATION & SEARCH (types) 21  Steepest Ascent Method  Response Surface Methodology (RSM)  Contour Plots
  • 22. Steepest Ascent Method 22 • Procedure for moving sequentially along the path (or direction) in order to obtain max. ↑ in response. • Applied to analyze the responses obtained from: 1. Factorial Designs 2. Fractional Factorial Designs NOTE: Initial estimates of DOE are far from actual, so method chosen for optimum value.
  • 23. Response Surface Methodology (RSM) 23 • A 3-D geometric representation that establishes an empirical relationship between responses & independent variables. • For:  Determining changes in response surface  Determining optimal set of experimental conditions NOTE: Overlap of plots for complete info is possible.
  • 24. Contour Plots 24 • Are 2-D (X1 & X2) graphs in which some variables are held at one desired level & specific response noted. • Both axes are in experimental units. • Sometimes both the contour & RSM plots are drawn together for better optimum values.
  • 25. Contour Plots 25 RSM & Contour Combined
  • 26. 26

Notas do Editor

  1. TERM = to make perfect used in pharmacy relative to formulation and processing. process of finding the best way of using the existing resources while taking in to the account of all the factors that influences decisions in any experiment
  2. TERM = to make perfect used in pharmacy relative to formulation and processing. process of finding the best way of using the existing resources while taking in to the account of all the factors that influences decisions in any experiment
  3. represented by evolutionary operations(EVOP), simplex methods. represented by classic mathematical & search methods
  4. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  5. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  6. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  7. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  8. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  9. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  10. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  11. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  12. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  13. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.