DNA (genetic) Vaccines

1. DNA (GENETIC) VACCINES

2. WHAT ARE DNA VACCINES?
More efficient way of
delivering vaccines for
your body to become
immune to diseases
There are both
advantages and
disadvantages to DNA
Vaccines

3. HOW ARE THEY MADE?
Remove a single
strand (RNA) of
genetic information
from a virus
This will kill the virus
Next, the strand is
converted to a double
strand (DNA) and is
encoded with an
antigen for the cells of
the host

4. HOW DOES IT
WORK?
Endogenous pathway
When the DNA vaccine is
delivered into the muscle cell
by any delivery method.
The DNA is consumed into the
nucleus of the cell
The genes are then
transferred to create mRNA
and the mRNA produces
proteins with the help of a
ribosome

5. HOW DOES IT WORK CONT.
Exogenous pathway
When viral peptides in
the cell go outside the
cell and are
phagocytosed by an
antigen helping them
become active

6. ADVANTAGE
S
High transfection
efficiency
Stability
Capability to encode a
number of immunological
components
Induce cellular and
humoral immune
responses
Lower cytotoxicity

7. DISADVANTAG
ES
Cannot not be produced in
large quantities
Toxic side effects
Limitations to transgene
size
Poor immunogenicity
Very expensive to produce
Can lead to destruction of
normal tissue

8. FUTURE OF DNA
VACCINES
DNA vaccines can only help
with infectious diseases,
but researchers hope to
make DNA vaccines that can
help with cancer and
autoimmune diseases
The regular vaccine will
most likely be around for a
while, but DNA vaccines
offer a safer, pain free, and
more effective way of
preventing diseases

9. Ph.: Fatimah Mohamed Shaheen