Nicotinamide Mononucleotide(NMN) Powder

Nicotinamide Mononucleotide(NMN) Powder:
The Direct NAD Precursor for Anti-aging
Jim Zheng（Jim@Cimasci.com)
Wuxi Cima Science Co.,Ltd

Copyright 2019 © Wuxi Cima Science Co.,Ltd All Rights Reserved.
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Table of Contents
ABOUT US
ABOUT NMN
Our Advantages

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ABOUT US

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• Cima Science is a technology-driven and forward-looking
manufacturer with more than 16 years’ experience in
nutrition industry.
• Committed to high quality herbal extracts, nutritional
chemicals, APIs and private label products.
• Four GMP-compliant production bases in china
• A skilled R&D team with doctor and master’s degrees
Wuxi Cima Science Co., Ltd
Key products:
• Palmitoylethanolamide(PEA)
• Oleoylethanolamide (OEA)
• Magnesium L-Threonate
• Alpha GPC
• Anti-aging series: PQQ, Resveratrol, Pterostilbene, NR, NMN

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ABOUT NMN

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What is Nicotinamide Mononucleotide?
Product name: Nicotinamide mononucleotide powder
Synonyms: NMN
CAS Number: 1094-61-7
Specifications: 99.0%min
Molecular Formula: C11H15N2O8P
Molecular Weight: 334.221 g/mol
Package: 1kg/bag, 25kg/drum
Nicotinamide mononucleotide (NMN), a derivative of vitamin B3, is a nucleotide that is most
recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+)
biosynthesis.

Food Sources of NMN
NMN content is too low.
The average dosage is about 300 mg
You need to eat too many foods
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NMN Benefits
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NMN Research on Aging
NMN was able to mitigate most age-associated physiological declines in mice
Treatment of old mice with NMN reversed all of these biochemical aspects of aging
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated
Physiological Decline in Mice (mills, 2016)
Raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse
Restore the mitochondrial homeostasis and key biochemical markers of muscle health in a
22-month-old mouse to levels similar to a 6-month-old mouse
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial
Communication during Aging (Gomes, Sinclair,2013)
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NMN Research on DNA Repair
DNA Repair
A conserved NAD+ binding pocket that regulates protein-protein
interactions during aging (Sinclair, 2017)
• This study showed supplementation with NMN was able to repair
the DNA in cells damaged by radiation
• The cells of old mice were indistinguishable from young mice after
just one week of treatment.
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NMN Research on Weight
• NMN was immediately utilized and converted to NAD+ within 15 min,
resulting in significant increases in NAD+ levels over 60 min
• Administering NMN, a key NAD+ intermediate, can be an effective
intervention to treat the pathophysiology of diet- and age-induced T2D
• Surprisingly, just one dose of NMN normalized impaired glucose tolerance
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the
Pathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011)
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NMN Research on Endurance
• NAD(+) levels were increased significantly both in muscle and liver by NMN
• NMN-supplementation can induce similar reversal of the glucose
intolerance
• NMN intervention is likely to be increased catabolism of fats NMN-
supplementation does mimic exercise
Head to Head Comparison of Short-Term Treatment with the NAD(+)
Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in
Obese Female Mice (Uddin, 2016)
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NMN Research on Brain
NMN treatment reduces brain cell death and oxidative stress These results
further support the neuroprotection of NMN/NAD+
Nicotinamide mononucleotide attenuates brain injury after intracerebral
hemorrhage by activating Nrf2/HO-1 signaling pathway (Wei, 2017)
We now demonstrate that mitochondrial respiratory function was restored
Effect of nicotinamide mononucleotide on brain mitochondrial respiratory
deficits in an Alzheimer’s disease-relevant murine model (Long, 2015)
NMN could restore cognition in AD model rats
Nicotinamide mononucleotide protects against β-amyloid oligomer-induced
cognitive impairment and neuronal death (Wang, 2016)
NMN Treatment Rescues Cognitive impairments
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer
disease (Yao, 2017)
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NMN Research on Heart
NMN significantly increased the level of NAD+ in the heart
NMN protected the heart from I/R injury
Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects
the heart from ischemia and repercussion (Yamamoto, 2014)
NMN reduces vascular oxidative stress
NMN treatment normalizes aortic stiffness in old mice
NMN represents a novel strategy for combating arterial aging
Nicotinamide mononucleotide supplementation reverses vascular
dysfunction and oxidative stress with aging in mice (de Picciotto, 2016)
NMN can reduce myocardial inflammation NMN thus can cut off the initial
inflammatory signal, leading to reduced myocardial inflammation
Short-term administration of Nicotinamide Mononucleotide preserves
cardiac mitochondrial homeostasis and prevents heart failure (Zhang, 2017)
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NMN Research on Energy
ENERGY
Remarkably, NMN administered to FXN-KO mice restores cardiac function to near-
normal levels.
Restoration of cardiac function and energy metabolism upon NMN supplementation
Remarkable decrease in whole-body EE and cardiac energy wasting
Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and
bioenergetics in a Friedreich’s ataxia cardiomyopathy model
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NMN Research on Vision
Exogenous NMN prevents photoreceptor degeneration and restores vision
NMN rescues retinal dysfunction in light-induced degeneration
NAMPT-mediated NAD+ biosynthesis is essential for vision in mice (lin, 2016)
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How does NMN Work?
NMN is a precursor to the NAD+ molecule; the human
body requires NMN in order to make its own NAD+.
NAD+ levels naturally decline as the body ages, by up to
50% in human skin tissue by the age of 40-60.
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How does NMN Work?
• Before 2019, experts believe NMN can only
convert to NR outside the barrier to enter
the cell, and then convert back to NMN,
then to NAD+( the solid route)
NMN NR NR NMN NAD+
Cross cell barrier
Slc12a8 is a nicotinamide mononucleotide transporter
NMN NMN NAD+
Cross cell barrier
Slc12a
8
• In Jan 2019, novel NMN transporter has
been identified. NMN is able to cross the
cell barrier and convert to NAD+
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NMN to NAD+
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How does NMN Work?
NMN enters cells through
co-transporter Slc12a8
The transport of NMN into the cell was thought to
require a dephosphorylation step to produce NR
before it could be taken up by ENTs.
The discovery of an NMN transporter raises new
questions about the uptake, distribution, and
utilization of NMN from the diet and in circulation
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Key Facts about NMN
•NMN treatment also significantly improves both insulin action and secretion in diet- and age-induced type 2 diabetic or
obese mouse models
•NMN ameliorates impairments in glucose-stimulated insulin secretion
•NMN protects the heart from ischemia/reperfusion injury by preventing NAD+ decrease induced by ischemia
•Restores skeletal muscle mitochondrial function and arterial function
•Ameliorates mitochondrial function, neural death, and cognitive function in Alzheimer’s disease
•Prevent DNA damage and hepatocellular carcinoma formation
•Improve noise-induced hearing loss
•Maintain muscle stem cell function
•Orally administered NMN is quickly absorbed, efficiently transported into blood circulation, and immediately converted to
NAD+ in major metabolic tissues
•Long-term administration of NMN is capable of mitigating age-associated physiological decline
•Suppresses age-associated body weight gain
•Enhances food intake, oxygen consumption, energy expenditure, and physical activity
•Improves insulin sensitivity and plasma lipid profile
•Improves eye function, bone density, and myeloid-lymphoid composition
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Our Advantages

GMP-Compliant Factory with ready stock
Package: 25kg/drum
Purity: 99.0%min
Capacity: 1.0 tons per month
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Advanced Manufacturing Process
• Environment-Friendly
• Cost-efficient
• Mass production
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NMN purity ⩾ 99.0%
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Nicotinamide Mononucleotide(NMN) Powder

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