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Hypersensitivity Reactions FE A. BARTOLOME, MD. FPASMAP  Department of Microbiology  Our Lady of Fatima University
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
TYPE I Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed
[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],[object Object],Type I Hypersensitivity
[object Object],[object Object],[object Object],Type II Hypersensitivity
[object Object],[object Object],[object Object],[object Object],Type II Hypersensitivity
MECHANISMS: Complement-Dependent Reactions Type II Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type II Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type II Hypersensitivity
MECHANISMS: Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Type II Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
[object Object],[object Object],[object Object],Type II Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type II Hypersensitivity
[object Object],[object Object],[object Object],Type III Hypersensitivity
Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th  ed.
Antigens Associated with Immune Complex Disorders Type III Hypersensitivity SLE Rheumatoid arthritis Glomerulonephritis ENDOGENOUS Nuclear antigens Immunoglobulins Tumor antigens Arthritis GN, Infective endocarditis Glomerulonephritis Polyarteritis nodosa Glomerulonephritis Farmer’s lung EXOGENOUS Infectious agents: Bacteria:  Y. enterocolitica Streptococci T. pallidum Viruses:  Hep. B, CMV Parasites:  Plasmodium Schistosoma Fungi:  Actinomycetes CLINICAL MANIFESTATION ANTIGEN
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type III Hypersensitivity
[object Object],[object Object],[object Object],Type IV Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type IV Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type IV Hypersensitivity
[object Object],[object Object],[object Object],[object Object],[object Object],Type IV Hypersensitivity

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Hypersensitivity

  • 1. Hypersensitivity Reactions FE A. BARTOLOME, MD. FPASMAP Department of Microbiology Our Lady of Fatima University
  • 2.
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  • 5. TYPE I Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed
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  • 8.
  • 9.
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  • 17. MECHANISMS: Complement-Dependent Reactions Type II Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed.
  • 18.
  • 19.
  • 20. MECHANISMS: Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Type II Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed.
  • 21.
  • 22.
  • 23.
  • 24. Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed.
  • 25. Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed.
  • 26. Type III Hypersensitivity Source: Robbins PATHOLOGIC BASIS OF DISEASE 6 th ed.
  • 27. Antigens Associated with Immune Complex Disorders Type III Hypersensitivity SLE Rheumatoid arthritis Glomerulonephritis ENDOGENOUS Nuclear antigens Immunoglobulins Tumor antigens Arthritis GN, Infective endocarditis Glomerulonephritis Polyarteritis nodosa Glomerulonephritis Farmer’s lung EXOGENOUS Infectious agents: Bacteria: Y. enterocolitica Streptococci T. pallidum Viruses: Hep. B, CMV Parasites: Plasmodium Schistosoma Fungi: Actinomycetes CLINICAL MANIFESTATION ANTIGEN
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.