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A Case of Antiphospholipid Antibody Syndrome

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Stanley Medical College, Department of Medicine
Saúde e medicina
1 de 53
Physician’s Meet March 17 2010 Dr Jishanth M Prof. Dr A Gowrishankar’s Unit, M4
An Interesting Hypercoagulable State
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
System Examination: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
PROVISIONAL DIAGNOSIS ,[object Object],[object Object],[object Object]
INVESTIGATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CXR PA VIEW
 
Investigation contd… ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
CT ANGIOGRAM ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Further investigations ,[object Object],[object Object],[object Object],[object Object],[object Object]
HRCT Chest
Interlobular septal thickening B/l cystic spaces with peribrochial fibrosis
FINAL DIAGNOSIS ,[object Object],[object Object],[object Object]
Antiphospholipid Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Antiphospholipid Syndrome - Etiology ,[object Object],[object Object],[object Object],[object Object]
Disease associations
Drug Induced aPLs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiphospholipid antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antiphospholipid Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiphospholipid Antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Beta 2 Glycoprotein I ,[object Object],[object Object],[object Object],[object Object],[object Object]
Significance of aPLs ,[object Object],[object Object]
APS Pathophysiology ,[object Object],platelets Coagulation cascade Endothelial cells Activate platelet aggregation Inhibit Protein C, Protein S, thrombomodulin, antithrombin III fibrinolysis TF, adhesion molecules and proinflammatory cytokines Placental tissue Trophoblastic cell growth, apoptosis IL-3 Complement system
APS Pathophysiology
Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
REVISED SAPPORO CRITERIA, SYDNEY 2006 Clinical Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Catastrophic APS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment-General ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anticoagulation ,[object Object],[object Object],[object Object]
Treatment-Other ,[object Object],[object Object],[object Object]
Treatment of Catastrophic APS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Future directions of treatment of APS ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]
Uniqueness of the case under discussion….
….THANK YOU….

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A Case of Antiphospholipid Antibody Syndrome

Notas do Editor

  1. Other triggers: surgical procedures DIC, rare in APS, more common in catastrophic APS