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Principle
of
Presbyopia Correcting IOLs
M.Khanlari , MD
Introduction
What are Monofocal IOLs?
• Monofocal IOLs have only one optical power
• Monofocal IOLs are usually implanted to correct the patient’s FAR
VISION
• As a matter of fact, the pseudophakic patient implanted with a
monofocal IOL has lost accommodation, therefore needs glasses for
NEAR CORRECTION
Far correction Near correction
Application
What are Multifocal IOLs?
• Bifocal IOLs bend or spread the light in two different focus points:
• one for NEAR VISON
• one for FAR VISION
• The goal of a multifocal implantation is to provide the
pseudophakic patient both corrections for FAR and NEAR VISION
simultaneous distance and and near correction
 Hoffer in 1982 was the first to hit upon the idea of a multifocal IOL
after observing a patient who had 6/6 vision in spite of an IOL that
was decentered by more than 50% of the pupillary area
 The credit goes to Dr John Pierece in 1986 who was to implant the
bull’s eye style of the multifocal IOL
Concepts for multifocal and presbyopia
correcting lenses
• Refractive bifocal lenses
• NaturaLens(Eyekon)
• Refractive birefringent bifocal lenses
• Refractive multifocal lenses
• Rezoom(Amo), Mflex(Rayner), Array(Amo)
• Asymmetric zonal refractive lenses
• Oculentis Mplus (Oculentis)
• Diffractive bifocal lenses
• Diffractive Multifocal lenses
• Restor(Alcon) , Tecnis (Abbot)
• Enlighten new trifocal
• Panoptix(Alcon)
• Hybrid diffractive/refractive trifocal lenses (LISA)
• ATlisa(zeiss), PhysIOL(Finevision)
• Extended depth of focus
Refraction vs. Diffraction
• Refraction: An optic with a smooth, continuous surface that bends light rays,
focusing them into a single image.
• Diffraction: An optic surface that contains physical steps, that divides light waves into
wavelets that form the near & distant images on the retina
Asymmetric zonal refractive lenses
Asymmetric zonal refractive lenses
• LENTIS Mplus IOL (Oculentis GmbH) one-piece zonal
refractive lens was the first commercially available IOL to
have a rotationally asymmetric design.
• It features plate haptics and two refractive segments,
• a large aspheric distance- vision zone and
• a sector-shaped near vision zone with an addition of 3.00 D to
direct light to a near focal point.
Compared with the LENTIS Mplus IOL (left), the Mplus X IOL (right)
features additive paraxial asphericity(APA) and surface desighn
optimisation(SDP)
Conventional refractive bifocal lenses
ReZoom RaynerMflexArray
Optical Principles
Refraction
Refraction is a fundamental property of light.
•Refraction is created when light passes media with different refractive indices
•Snell’s (Descartes‘) law of refraction provides the basis of calculation:
n sin i = n‘ sin i‘
• Essential characteristics:
– The law of refraction is non-linear!
Most types of aberrations are due to these non-linear effects!
– Also applies to reflection (negative refractive index!)
– For small angles of incidence, the law of refraction
can be linearized:
n i = n‘ i‘ (paraxial approximation)
n‘
n
i
i‘
Optical Principles
How do refractive multifocal IOLs work?
• 2 to 7 refractive zones, alternating for near and far focus
• function depends on the pupil size and centration
• segmented surfaces with well defined power
• Distance / Near energy split accomplished by geometric
segmentation of pupil
21.10.2009
near focus far focus
near power zone
in the distance focus ray 1 and ray 2
exhibit an optical path length difference
consequence: partially destructive
interference
wavefront
ray 1 through a zone
of distance power
ray 2 through a zone
of distance power
additional
path t
Drawbacks:
•Pupil size dependent
•Wave optics conditions “phase matching” not fulfilled
•“diffractive mismatch“ causes image degradation
Conventinal refractive bifocal lenses
n=near
e.g. IOLAB
NuVue
e.g. Storz
True Vista
Zonal Refractive Multifocal Lenses
d=distance
e.g. AMO
Array
d n
d
n
d
n
d
2 zones 3 zones
5 zones
d
Zonal Refractive
• Uses the concept of refraction to create an optic that provides multiple
images
• Intermittent refractive rings are placed in different zones of the optic
• One ring is dedicated to distance, another to near
Zonal Refractive Multifocal Lenses
 Lens surface is not continuous (i.e., smooth)
The boundaries between zones are optical
discontinuities
 Annular (ring-shaped) lens regions have reduced
image quality
Light spreads out at the inner & outer boundaries
d n
d
n
Refractive Multifocal IOL
d n
d
n
Light energy equally shared
over broad range of
pupils/lighting conditions,
contributes to halos at night
Light energy equally shared for
bright to moderate lighting/pupils
– apodization gradually increases
distance energy with larger pupils
- reduces halos at night
Zonal Refractive (5 Zones) – AMO Array
Full Optic Diffractive – 3M/Pfizer 811E
Apodized Diffractive - Alcon
d
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5
Pupil Diameter (mm)
RelativeEnergy
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5 6
Pupil Diameter (mm)
RelativeEnergy
Distance Focus
Near Focus0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5
Pupil Diameter (mm)
FractionalEnergy
AMOd AMOn
Light energy dramatically varies
with number of zones exposed by
pupil, contributes to halos at night
0
0.5
1
1.5
2
2.5
3
Distance
Distance
Distance
Near
Near
Conventional Diffractive lenses
Tecnis FinevisinRestor
What is a wavefront?
plano wavefront
circular wavefont distorted wavefront
Light ray = wave train
Wave trains in parallel phase relation
Constructive interference
•two light trains (blue & red) oscillate in parallel
•the resultant light train (green) has an amplitude
which is twice the individual
amplitudesWave trains in opposite phase relation
Destructive interference
•two light trains (blue & red) oscillate in
opposite direction
•the resultant light train(green) amplitude
is 0General case:
Partially destructive interference
•two light trains (blue & red) oscillate in
arbitrary, but constant phase relation
•the resultant light train(green) amplitude
is between 0 and total sum of both aplitudes
Phase relation and interference of
waves
Optical Principles
Principles of Diffraction
Diffraction
•Diffraction is the bending of waves round an obstacle or through a hole
•Plane waves are transformed into spherical waves after diffraction
•Spherical wave propagation form different diffraction points leads to wave interference
according to the Huygens-Fresnel principle
•Interference refers to the combination of two or more wave fronts
• Wave interference patterns depend on phase shifts between
different wave fronts
• Destructive interference due to opposite phase relation leads
to 0 amplitude
• Constructive interference due to parallel phase relation results
in new wave with2x the amplitude, creating focal points
•Diffraction technology and interference patterns are utilized in IOLs to create more than one focal point
Optical Principles
Diffraction
• Described by Thomas Young for the first time
• Occur when a wave encounters an obstacle or a slit
• Interference of waves according the the Huygens–Fresnel
principle
• Plane wave transformed into spherical waves after diffraction
• light waves incident on two slits will spread out and exhibit an interference pattern in
the region beyond.
02/21/19 21
incident wave
step
index n1
lens
index n2
> n1
index n1
destructive interference
(zero intensity)
constructive interference(first diffractive order)
constructive interference
(zeroth diffractive order)
• With the introduction of an optical step between lens zones it can be achieved that
Light interferes constructively in more than one direction
• Mind: the refractive power of the zones is different from both the zeroth and the first
diffractive lens power
Optical Principles
How do diffractive IOLs work?
•the higher the grating density the
stronger is the angle deviation of
the light
•the more rings are placed on a
lens surface the higher is usually
the add power
Basic principles of diffractive elements
Grating density and diffraction angles
low ring density
medium ring density
high ring density
24
Diffraction
Diffractive Steps
 Step width determines addition power+3D, +4D, +3.75D
○ Short steps  high addition
○ Wide steps  small addition
02/21/19
↖
02/21/19 25
Diffraction
Diffractive Steps
ffects of the width of the diffraction steps:
26
Diffraction
Diffractive Steps
 Step height determines energy repartition between far
and near vision
○ High steps  more energy for near vision
○ Small steps  more energy for far vision
02/21/19
↖
27
Diffraction
Deffractive Steps
 Variable step height from center to periphery
○ Apodization
02/21/19
ReSTOR Single piece optic
 Optic Diameter
 Optic Type
 Haptic angulation
 Diopters
− 6.0 mm
− Apodized diffractive surface - central 3.6 mm /
Refractive - outer 2.4 mm
− +4 Diopter add power for near vision equals +3.2 Diopter
at spectacle plane
− +3 Diopter add power for near vision equals +2.25
Diopter at spectacle plane
− 0 degrees - planar
− 6 - 34 Dpt
Apodized Diffractive Optic
Step heights
decrease
peripherally from
1.3 – 0.2 microns
A +4.0 add at lens
plane equaling
+3.2 at spectacle
plane
Central 3.6 mm
diffractive
structure
Patented
peripherally
decreasing
zone widths
Alcon internal use only - do not distribute!
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5 6
Pupil diameter (mm)
Relativeenergy
Distant focus
Near focus
Above max. 82%!
Near vision: Photopic
vision (reading)
Distance vision
Mesopic vision
Alcon internal use only - do not distribute!
Refractive MF and Diffractive IOLs
d n
d
n
Light energy equally shared
over broad range of
pupils/lighting conditions,
contributes to halos at night
Light energy equally shared for
bright to moderate lighting/pupils
– apodization gradually
increases distance energy with
larger pupils - reduces halos at
night
Zonal Refractive (5 Zones) – AMO ARRAY
Full Optic Diffractive – 3M
Apodized Diffractive – Alcon ReSTOR
d
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5
Pupil Diameter (mm)
RelativeEnergy
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5
Pupil Diameter (mm)
RelativeEnergy
Light energy dramatically varies
with number of zones exposed
by pupil, contributes to halos at
night
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
1 2 3 4 5 6
Pupil Diameter (mm)
Distance Focus
Near Focus
RelativeEnergy
Diffractive Technology comparison
 Traditional bifocal IOLs:
• 1 step height = 1 add power
• May sacrifice good intermediate
vision for better near & distance
Step 1: 40 cm
Diffractive Technology comparison
 Traditional bifocal IOLs:
• 1 step height = 1 add power
• May sacrifice good intermediate vision
for better near & distance
 Current Trifocal:
• 2 step heights = 2 add powers
• Intermediate focal point of 80 cm to
maintain usable near vision
Step 1: 40 cm
Step 2: 80 cm
Diffractive Technology comparison
 Traditional bifocal IOLs:
• 1 step height = 1 add power
• May sacrifice good intermediate vision for better
near & distance
 Current Trifocal:
• 2 step heights = 2 add powers
• Intermediate focal point of 80 cm to maintain
usable near vision
 New Quadrafocal Technology:
• 3 step heights = 3 add powers
• More continuous vision
• May sacrifice distance contrast
Step 1: 40 cm
Step 3: 120 cm
Step 2: 60 cm
Diffractive Technology comparison
 Traditional bifocal IOLs:
• 1 step height = 1 add power
• May sacrifice good intermediate vision for
better near & distance
 Current Trifocal:
• 2 step heights = 2 add powers
• Intermediate focal point of 80 cm to
maintain usable near vision
 ENLIGHTEN™ Optical
Technology:
• Non-apodized new trifocal design
• Redirects light from the 3rd
step height to
distance
Step 1: 40 cm
Step 2: 60 cm
Diffractive Technology comparison
 Traditional bifocal IOLs:
• 1 step height = 1 add power
• May sacrifice good intermediate vision for
better near & distance
 Current Trifocal:
• 2 step heights = 2 add powers
• Intermediate focal point of 80 cm to maintain
usable near vision
 ENLIGHTEN™ Optical Technology:
• Non-apodized new trifocal design
• Redirects light from the 3rd
step height to
distance
Enlighten new trifocal
Panoptix(Alcon)
Benefit #1: optimized light utilization
 Transmits 88% of light at 3 mm
pupil size to the retina1,2
• Allocates half of light to distance
• Splits the rest evenly between near and
intermediate
• Other Trifocals*
= 86%†,3
*Trademarks are the property of their respective owners.
†
At 3.0 mm aperture pupil size.
1. AcrySof® IQ PanOptix™ IOL Directions for Use. 2. Alcon Laboratory Notebook:14073:77. 3. Gatinel D, Pagnoulle C, Houbrechts
Y, Gobin L. Design and qualification of a diffractive trifocal optical profile for intraocular lenses. J Cataract Refract Surg.
2011;37(11):2060-2067.
Total Light Energy Distribution1
Distance
+
Near
+
Intermediate
=
88%†,2
PAN15013SKi
Benefit #2: DESIGNED FOR more comfortable near to intermediate range
•40-80 cm range of vision1
•Intermediate focal point of 60 cm1,2
○ Other trifocals = 80 cm3,4
1. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723. Effective date 19 Dec 2014. 2. Alcon Laboratory Notebook:14073:78. 3. ZEISS AT LISA* IOL Sales Brochure. 4. PhysIOL FineVision* Sales Brochure
*Trademarks are the property of their respective owners
Theoretical Defocus Curve2
PAN15013SKi
Intermediate Focal Distance Comparison1
Image-based visual acuity (VA) estimation method is computationally configured via artificial neural network architecture based on four IOLs with published
clinical VA data.
1. Alcon Laboratory Notebook:14073:78. 2. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723.
Effective date 19 Dec 2014. 3. Charness N, Dijkstra K, Jastrzembski T, et al. Monitor viewing distance for younger and older
workers. Proceedings of the Human Factors and Ergonomics Society 52nd Annual Meeting, 2008.
http://www.academia.edu/477435/Monitor_Viewing_Distance_for_Younger_and_Older_Workers. Accessed April 9, 2015. 4.
Average of American OSHA, Canadian OSHA and American Optometric Association Recommendations for Computer Monitor
Distances.
1
2
PAN15013SKi
Benefit #3: less dependence on pupil size1
Features 4.5 mm diffractive zone for less pupil
dependence1,2
•Multifocal < 4.0 mm3
•Other trifocals > 5.0 mm4,5
1. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723. Effective date 19 Dec 2014. 2. AcrySof® IQ PanOptix™ IOL Directions for Use.
3. AcrySof® IQ ReSTOR® +3.0 D IOL Directions for Use. 4. ZEISS AT LISA* IOL Sales Brochure. 5. PhysIOL FineVision* Sales Brochure. *Trademarks are the property
of their respective owners.
PAN15013SKi
Why Diffractive Zone Size matters
 4.5 mm = designed to be less dependent on
pupil size or lighting conditions
• Smaller = May compromise near and
intermediate performance in low light or in
large-pupil patients
• Larger = May compromise contrast sensitivity
and impact visual disturbances, such as glare
and halo
Distanc
e
PAN15013SKi
Hybrid diffractive/refractive trifocal lenses (LISA)
Atilisa(zeiss)
AT.LISA Principles – SMP-Technology
 SMP-Technology (smooth micro phase technology) is a worldwide unique patented
technique to create a lens surface
 The lens surface does not exhibit any square edges or sharp angles.
 Guarantees ideal optical imaging quality without any scattered light
 A diffractive focus can be generated which correlates with the theoretically required
surface structures of the lens
AT LISA Principles
Smooth Micro Phase (SMP) Lathing Technology
Concept LISA
L : Light distributed asymmetrically (between F
and N : halos and glare)↓
I : Independency from pupil size
S : SMP technology no right angles for reduced light
scattering
A : Aberration correcting optimized aspheric
optic ( contrast sensitivity, depth of field and sharper↑
vision)
True Living Vision
For excellent optical efficiency by day
Extended Depth of Focus (EDOF or EDF)
Extended Range of Vision
Tecnis Symphony AT Lara (Zeiss) IC8
Basic principles of diffractive elements
Chromatic aberration
Tecnis Symphony
 TECNIS Symfony IOL is the first FDA approved lens of its class.[1]
 The IOL has a biconvex wavefront-designed anterior aspheric surface
and a posterior achromatic diffractive surface with an echelette design.
 This proprietary format creates an achromatic diffractive pattern that
elongates a single focal point and compensates for the chromatic
aberration of the cornea.
IC 8 IOL
 Applying the same small-aperture principle optics as the
KAMRA inlay,the IC-8 IOL incorporates a non-diffractive 3.23
mm diameter opaque mask with a 1.36 mm central aperture
embedded within a 6.0 mm one-piece hydrophobic acrylic lens.
 The mask creates a pinhole effect, which delivers nearly 3.0
diopters of extended depth of focus by blocking unfocused
peripheral light rays and isolating more focused central and
paracentral rays through the central aperture2.
Maximizing outcomes
 Accurate selection of patients
 Biometry : Calculation of lens power
 Choice of lens model
 Con-struction of astigmatically neutral incision
 No perfect device available for correction of presbyopia
 Patients should have reasonable expectations
 Operate on healthy eyes
 Best candidates presbyopic hyperopes
 Pa-tients who must drive at night not generally good
candidates for multifocal IOLs
Choice of lens model
 Refractive Multifocal IOLs
ReZoom:
M-flex:
Sulcoflex:
AF-1 iSii:
 Diffractive Multifocal IOLs
ReSTOR: spectacle independence of 88% reported
TECNIS: 93% spectacle independence reported
TECNIS SYMPHONY
Acri.LISA:, toric version corrects £12 D
PANOPTIX
Multifocal IOLs
Restore ,Rezoom and …
 Accurate preoperative biometry is essential to attaining optimal results with the Multifocal IOLs.
Preoperative biometry measurements include axial length and corneal curvature.
 Axial Length
Use of a IOLMaster (optical biometry ) or standard immersion A-scan is recommended
 Keratometry
manually or by an automated method.
 Personalisation
It is important to target emmetropia and to personalise the A constants for all IOLs.
 Formula
Calculations on patients with axial lengths of between 22 and 25 mm with corneal powers of between
42.00 and 46.00 D will do well with current third-generation formulas (the Holladay 1,SRK/T,and
Hoffer Q). For cases outside this range, the Holladay 2 or optimized haigis should be used to ensure
accurac
 Astigmatism
Post-operative astigmatism needs to be reduced to one diopter or less. For patients with astigmatism
greater than this, limbal relaxing incisions, LASIK, or other corneal refractive procedures may be
needed
 Although IOL design is the primary factor in the constant , variation in surgical technique such as
The placement of the Iol
The location of the incision
design of the axiometers and keratometers also affects the personalized lens constant
 Most surgeon must perform 20 to 40 cases in order to personalize their lens constant
A constant
nominal
A constant
SRKII
A constant
SRKT
Haigis
A0
Haigis
A1
Haigis
A2
P ACD SF
Restor
SA60D3
118.1 118.7 118.5 -0.123 0.099 0.189 5.23 1.46
Restor
SA60D1
118.9 119.3 119.1 0.385 0.197 0.204 5.61 1.83
Acrilisa
tri839MP
118.3 119.0 118.9 -1.477 0.058 0.262 5.48 1.72
AMO Tecnis
ZMB00
118.8 119.7 119.7 1.73 0.40 0.10 5.96 2.15
Alcon Panoptix
TFNT00
119.1 119.3 119.1 1.39 0.40 0.10 5.63 1.83
AMO Tecnis 1
ZCB00
118.8 119.6 119.3 -1.302 0.210 0.251 5.80 2.02
Multifocal IOLs
Personalization…
Multifocal toric IOLs and online calculation
Multifocal toric IOLs and online calculation
Multifocal IOLs
CHOOSING THE POSTOPERATIVE REFRACTIVE TARGET
 Determining the desired postoperative refractive target for multifocal IOLs is
slightly different than for monofocal IOLs, where a slight amount of myopia may be
beneficial.
 With the refractive ReZoom and AcrySof Restor ,Panoptix, Acrilisa or Tecnis
multifocal the target should be
exactly zero (plano) or the nearest hyperopic choice to zero. Patients' near vision with each
of these lenses is excellent, but slight myopia moves the near point too close for comfortable
reading.
 With the Symphony aim for plano in 1 eye and -0.75 in the second eye to get
excellent reading and distance vision
 This choice must be discussed with patients, however, especially if they may
compare their two eyes for distance.
 They should understand the possibility of a slight sacrifice in depth perception to
have near vision in one eye.
•all diffraction orders occur simultaneously
•blazed structures help to suppress disturbing and unwanted orders
•unwanted orders create stray light and reduce overall contrast
Basic principles of diffractive elements
Diffraction orders
61
Diffraction
Diffractive Steps
 Same step height over whole optic surface
○ Same energy repartition between far/near whatever pupil aperture
02/21/19
Diffraction/Refraction
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
Cornea ReSTOR Retina
Near focus Distant focus
5 mm pupil
Distant
object
Alcon internal use only - do not distribute!
Step width determines the addStep width determines the add
power (+4.0D)power (+4.0D)
Step height determines theStep height determines the
amount of light at near focusamount of light at near focus
• Geometry is very important:
– Diffractive steps developed
to direct the light
– The light from every step is
focused at near and distant
focal points
Alcon internal use only - do not distribute!
Binocular Defocus Curve
Refraction (D)
IQ ReSTOR®
IOL +3.0 D [N=117] IQ ReSTOR®
IOL +4.0 D [N=114]
70 cm
(28 in)
50 cm
(20 in)
40 cm
(16 in)
33 cm
(13 in)
∞
20/25
20/32
20/40
20/50
20/63
20/80
20/100
20/20
+1.00 +0.50 0.00 -0.50 -1.00 -1.50 -2.00 -2.50 -3.00 -3.50 -4.00
Snellen
• Optical performance of the ReSTOR +3.0 Aspheric and ReSTOR +4.0 Aspheric
IOL are similar
Optical Performance Comparison
Measured Distance and Near Optical Quality
Modified ISO Model Eye
MTF @ 100 lp/mm (30 cpd)
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
5mm, distance 3mm, distance
MTF
ReSTOR® Asph. +4 D (n=10)
ReSTOR® Asph. +3 D (n=10)
Halo Performance Comparison
Line Spread Function generated by near add when viewing distance target
 The apodized diffractive optic in the ReSTOR IOLs generates significantly less
halos on the bench.
 The ReSTOR +3.0 D Aspheric IOL decreases halos on the bench as compared with
the existing ReSTOR +4.0 D IOL.
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in model eye with 0.2 um spherical aberration and 5 mm pupil)
0.000
0.050
0.100
0.150
0.200
0.250
0.300
0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24
Image location (mm)
Intensityrelativetopeak
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIOL ZM900
Halos
Focused
distance images
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIultifocal ZM900
(Modified ISO Model Eye with 5 mm pupil)
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis Multifocal ZM900
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in Modified ISO Model Eye with 5 mm pupil)
®
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in model eye with 0.2 um spherical aberration and 5 mm pupil)
0.000
0.050
0.100
0.150
0.200
0.250
0.300
0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24
Image location (mm)
Intensityrelativetopeak
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIOL ZM900
Halos
Focused
distance images
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIultifocal ZM900
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in model eye with 0.2 um spherical aberration and 5 mm pupil)
0.000
0.050
0.100
0.150
0.200
0.250
0.300
0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24
Image location (mm)
Intensityrelativetopeak
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIOL ZM900
Halos
Focused
distance images
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in model eye with 0.2 um spherical aberration and 5 mm pupil)
0.000
0.050
0.100
0.150
0.200
0.250
0.300
0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24
Image location (mm)
Intensityrelativetopeak
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIOL ZM900
Halos
Focused
distance images
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIultifocal ZM900
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis MIultifocal ZM900
(Modified ISO Model Eye with 5 mm pupil)
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis Multifocal ZM900
Array SA40N
ReSTOR Apsheric +4 D Add
ReSTOR Aspheric +3 D Add
Current ReSTOR +4 D Add
Tecnis Multifocal ZM900
Comparison of measured halos
of 3 ReSTOR IOLs to 2 other multifocal IOLs
(in Modified ISO Model Eye with 5 mm pupil)
®
 Human hair thickness: 60 microns
 Red blood cell diameter: 7 microns
 Step height at periphery IOL: 0.2 microns
Technology of the ReSTOR apodization IOL in ‘human’ terms
Add Power Comparison*
Spectacle plane
IOL & Add Effective Add Reading Distance
ReSTOR®
4.0D 3.00D 33.3 cm / 13.5”
ReSTOR®
3.0D 2.25D 43.5 cm / 17.8”
ReZoom** 3.5D 2.63D 38.5 cm / 15.7”
Tecnis** 4.0D 2.66D 37.0 cm / 15.1”
* Bench Data: Actual reading distance will depend on biometry, lens* Bench Data: Actual reading distance will depend on biometry, lens
position and other patient-related factors. Clinical experience withposition and other patient-related factors. Clinical experience with
ReSTORReSTOR 4.0 demonstrated an effective add power of 3.2D.4.0 demonstrated an effective add power of 3.2D.
****
ReZoom and Tecnis trademarks of Abbott Medical Optics, Inc.ReZoom and Tecnis trademarks of Abbott Medical Optics, Inc.
Alcon internal use only - do not distribute!
Optical Principles
Principle of Diffraction
•Diffraction is the ability of light to bend around edges
•Waves are subject to diffraction if they encounter, e.g.
Obstruction
Aperture
•Diffraction depends on wavelength:
Green light has a wider wave length than the blue light
Therefore the green picture is more expanded than
the blue one

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Principle of presbyopia correcting iols

  • 2. Introduction What are Monofocal IOLs? • Monofocal IOLs have only one optical power • Monofocal IOLs are usually implanted to correct the patient’s FAR VISION • As a matter of fact, the pseudophakic patient implanted with a monofocal IOL has lost accommodation, therefore needs glasses for NEAR CORRECTION Far correction Near correction
  • 3. Application What are Multifocal IOLs? • Bifocal IOLs bend or spread the light in two different focus points: • one for NEAR VISON • one for FAR VISION • The goal of a multifocal implantation is to provide the pseudophakic patient both corrections for FAR and NEAR VISION simultaneous distance and and near correction
  • 4.  Hoffer in 1982 was the first to hit upon the idea of a multifocal IOL after observing a patient who had 6/6 vision in spite of an IOL that was decentered by more than 50% of the pupillary area  The credit goes to Dr John Pierece in 1986 who was to implant the bull’s eye style of the multifocal IOL
  • 5. Concepts for multifocal and presbyopia correcting lenses • Refractive bifocal lenses • NaturaLens(Eyekon) • Refractive birefringent bifocal lenses • Refractive multifocal lenses • Rezoom(Amo), Mflex(Rayner), Array(Amo) • Asymmetric zonal refractive lenses • Oculentis Mplus (Oculentis) • Diffractive bifocal lenses • Diffractive Multifocal lenses • Restor(Alcon) , Tecnis (Abbot) • Enlighten new trifocal • Panoptix(Alcon) • Hybrid diffractive/refractive trifocal lenses (LISA) • ATlisa(zeiss), PhysIOL(Finevision) • Extended depth of focus
  • 6. Refraction vs. Diffraction • Refraction: An optic with a smooth, continuous surface that bends light rays, focusing them into a single image. • Diffraction: An optic surface that contains physical steps, that divides light waves into wavelets that form the near & distant images on the retina
  • 8. Asymmetric zonal refractive lenses • LENTIS Mplus IOL (Oculentis GmbH) one-piece zonal refractive lens was the first commercially available IOL to have a rotationally asymmetric design. • It features plate haptics and two refractive segments, • a large aspheric distance- vision zone and • a sector-shaped near vision zone with an addition of 3.00 D to direct light to a near focal point.
  • 9. Compared with the LENTIS Mplus IOL (left), the Mplus X IOL (right) features additive paraxial asphericity(APA) and surface desighn optimisation(SDP)
  • 10. Conventional refractive bifocal lenses ReZoom RaynerMflexArray
  • 11. Optical Principles Refraction Refraction is a fundamental property of light. •Refraction is created when light passes media with different refractive indices •Snell’s (Descartes‘) law of refraction provides the basis of calculation: n sin i = n‘ sin i‘ • Essential characteristics: – The law of refraction is non-linear! Most types of aberrations are due to these non-linear effects! – Also applies to reflection (negative refractive index!) – For small angles of incidence, the law of refraction can be linearized: n i = n‘ i‘ (paraxial approximation) n‘ n i i‘
  • 12. Optical Principles How do refractive multifocal IOLs work? • 2 to 7 refractive zones, alternating for near and far focus • function depends on the pupil size and centration • segmented surfaces with well defined power • Distance / Near energy split accomplished by geometric segmentation of pupil 21.10.2009 near focus far focus
  • 13. near power zone in the distance focus ray 1 and ray 2 exhibit an optical path length difference consequence: partially destructive interference wavefront ray 1 through a zone of distance power ray 2 through a zone of distance power additional path t Drawbacks: •Pupil size dependent •Wave optics conditions “phase matching” not fulfilled •“diffractive mismatch“ causes image degradation Conventinal refractive bifocal lenses
  • 14. n=near e.g. IOLAB NuVue e.g. Storz True Vista Zonal Refractive Multifocal Lenses d=distance e.g. AMO Array d n d n d n d 2 zones 3 zones 5 zones d Zonal Refractive • Uses the concept of refraction to create an optic that provides multiple images • Intermittent refractive rings are placed in different zones of the optic • One ring is dedicated to distance, another to near
  • 15. Zonal Refractive Multifocal Lenses  Lens surface is not continuous (i.e., smooth) The boundaries between zones are optical discontinuities  Annular (ring-shaped) lens regions have reduced image quality Light spreads out at the inner & outer boundaries d n d n
  • 16. Refractive Multifocal IOL d n d n Light energy equally shared over broad range of pupils/lighting conditions, contributes to halos at night Light energy equally shared for bright to moderate lighting/pupils – apodization gradually increases distance energy with larger pupils - reduces halos at night Zonal Refractive (5 Zones) – AMO Array Full Optic Diffractive – 3M/Pfizer 811E Apodized Diffractive - Alcon d 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 Pupil Diameter (mm) RelativeEnergy 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 6 Pupil Diameter (mm) RelativeEnergy Distance Focus Near Focus0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 Pupil Diameter (mm) FractionalEnergy AMOd AMOn Light energy dramatically varies with number of zones exposed by pupil, contributes to halos at night 0 0.5 1 1.5 2 2.5 3 Distance Distance Distance Near Near
  • 18. What is a wavefront? plano wavefront circular wavefont distorted wavefront Light ray = wave train
  • 19. Wave trains in parallel phase relation Constructive interference •two light trains (blue & red) oscillate in parallel •the resultant light train (green) has an amplitude which is twice the individual amplitudesWave trains in opposite phase relation Destructive interference •two light trains (blue & red) oscillate in opposite direction •the resultant light train(green) amplitude is 0General case: Partially destructive interference •two light trains (blue & red) oscillate in arbitrary, but constant phase relation •the resultant light train(green) amplitude is between 0 and total sum of both aplitudes Phase relation and interference of waves
  • 20. Optical Principles Principles of Diffraction Diffraction •Diffraction is the bending of waves round an obstacle or through a hole •Plane waves are transformed into spherical waves after diffraction •Spherical wave propagation form different diffraction points leads to wave interference according to the Huygens-Fresnel principle •Interference refers to the combination of two or more wave fronts • Wave interference patterns depend on phase shifts between different wave fronts • Destructive interference due to opposite phase relation leads to 0 amplitude • Constructive interference due to parallel phase relation results in new wave with2x the amplitude, creating focal points •Diffraction technology and interference patterns are utilized in IOLs to create more than one focal point
  • 21. Optical Principles Diffraction • Described by Thomas Young for the first time • Occur when a wave encounters an obstacle or a slit • Interference of waves according the the Huygens–Fresnel principle • Plane wave transformed into spherical waves after diffraction • light waves incident on two slits will spread out and exhibit an interference pattern in the region beyond. 02/21/19 21
  • 22. incident wave step index n1 lens index n2 > n1 index n1 destructive interference (zero intensity) constructive interference(first diffractive order) constructive interference (zeroth diffractive order) • With the introduction of an optical step between lens zones it can be achieved that Light interferes constructively in more than one direction • Mind: the refractive power of the zones is different from both the zeroth and the first diffractive lens power Optical Principles How do diffractive IOLs work?
  • 23. •the higher the grating density the stronger is the angle deviation of the light •the more rings are placed on a lens surface the higher is usually the add power Basic principles of diffractive elements Grating density and diffraction angles low ring density medium ring density high ring density
  • 24. 24 Diffraction Diffractive Steps  Step width determines addition power+3D, +4D, +3.75D ○ Short steps  high addition ○ Wide steps  small addition 02/21/19 ↖
  • 25. 02/21/19 25 Diffraction Diffractive Steps ffects of the width of the diffraction steps:
  • 26. 26 Diffraction Diffractive Steps  Step height determines energy repartition between far and near vision ○ High steps  more energy for near vision ○ Small steps  more energy for far vision 02/21/19 ↖
  • 27. 27 Diffraction Deffractive Steps  Variable step height from center to periphery ○ Apodization 02/21/19
  • 28. ReSTOR Single piece optic  Optic Diameter  Optic Type  Haptic angulation  Diopters − 6.0 mm − Apodized diffractive surface - central 3.6 mm / Refractive - outer 2.4 mm − +4 Diopter add power for near vision equals +3.2 Diopter at spectacle plane − +3 Diopter add power for near vision equals +2.25 Diopter at spectacle plane − 0 degrees - planar − 6 - 34 Dpt
  • 29. Apodized Diffractive Optic Step heights decrease peripherally from 1.3 – 0.2 microns A +4.0 add at lens plane equaling +3.2 at spectacle plane Central 3.6 mm diffractive structure Patented peripherally decreasing zone widths Alcon internal use only - do not distribute!
  • 30. 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 6 Pupil diameter (mm) Relativeenergy Distant focus Near focus Above max. 82%! Near vision: Photopic vision (reading) Distance vision Mesopic vision Alcon internal use only - do not distribute!
  • 31. Refractive MF and Diffractive IOLs d n d n Light energy equally shared over broad range of pupils/lighting conditions, contributes to halos at night Light energy equally shared for bright to moderate lighting/pupils – apodization gradually increases distance energy with larger pupils - reduces halos at night Zonal Refractive (5 Zones) – AMO ARRAY Full Optic Diffractive – 3M Apodized Diffractive – Alcon ReSTOR d 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 Pupil Diameter (mm) RelativeEnergy 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 Pupil Diameter (mm) RelativeEnergy Light energy dramatically varies with number of zones exposed by pupil, contributes to halos at night 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1 2 3 4 5 6 Pupil Diameter (mm) Distance Focus Near Focus RelativeEnergy
  • 32. Diffractive Technology comparison  Traditional bifocal IOLs: • 1 step height = 1 add power • May sacrifice good intermediate vision for better near & distance Step 1: 40 cm
  • 33. Diffractive Technology comparison  Traditional bifocal IOLs: • 1 step height = 1 add power • May sacrifice good intermediate vision for better near & distance  Current Trifocal: • 2 step heights = 2 add powers • Intermediate focal point of 80 cm to maintain usable near vision Step 1: 40 cm Step 2: 80 cm
  • 34. Diffractive Technology comparison  Traditional bifocal IOLs: • 1 step height = 1 add power • May sacrifice good intermediate vision for better near & distance  Current Trifocal: • 2 step heights = 2 add powers • Intermediate focal point of 80 cm to maintain usable near vision  New Quadrafocal Technology: • 3 step heights = 3 add powers • More continuous vision • May sacrifice distance contrast Step 1: 40 cm Step 3: 120 cm Step 2: 60 cm
  • 35. Diffractive Technology comparison  Traditional bifocal IOLs: • 1 step height = 1 add power • May sacrifice good intermediate vision for better near & distance  Current Trifocal: • 2 step heights = 2 add powers • Intermediate focal point of 80 cm to maintain usable near vision  ENLIGHTEN™ Optical Technology: • Non-apodized new trifocal design • Redirects light from the 3rd step height to distance Step 1: 40 cm Step 2: 60 cm
  • 36. Diffractive Technology comparison  Traditional bifocal IOLs: • 1 step height = 1 add power • May sacrifice good intermediate vision for better near & distance  Current Trifocal: • 2 step heights = 2 add powers • Intermediate focal point of 80 cm to maintain usable near vision  ENLIGHTEN™ Optical Technology: • Non-apodized new trifocal design • Redirects light from the 3rd step height to distance
  • 38. Benefit #1: optimized light utilization  Transmits 88% of light at 3 mm pupil size to the retina1,2 • Allocates half of light to distance • Splits the rest evenly between near and intermediate • Other Trifocals* = 86%†,3 *Trademarks are the property of their respective owners. † At 3.0 mm aperture pupil size. 1. AcrySof® IQ PanOptix™ IOL Directions for Use. 2. Alcon Laboratory Notebook:14073:77. 3. Gatinel D, Pagnoulle C, Houbrechts Y, Gobin L. Design and qualification of a diffractive trifocal optical profile for intraocular lenses. J Cataract Refract Surg. 2011;37(11):2060-2067. Total Light Energy Distribution1 Distance + Near + Intermediate = 88%†,2 PAN15013SKi
  • 39. Benefit #2: DESIGNED FOR more comfortable near to intermediate range •40-80 cm range of vision1 •Intermediate focal point of 60 cm1,2 ○ Other trifocals = 80 cm3,4 1. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723. Effective date 19 Dec 2014. 2. Alcon Laboratory Notebook:14073:78. 3. ZEISS AT LISA* IOL Sales Brochure. 4. PhysIOL FineVision* Sales Brochure *Trademarks are the property of their respective owners Theoretical Defocus Curve2 PAN15013SKi
  • 40. Intermediate Focal Distance Comparison1 Image-based visual acuity (VA) estimation method is computationally configured via artificial neural network architecture based on four IOLs with published clinical VA data. 1. Alcon Laboratory Notebook:14073:78. 2. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723. Effective date 19 Dec 2014. 3. Charness N, Dijkstra K, Jastrzembski T, et al. Monitor viewing distance for younger and older workers. Proceedings of the Human Factors and Ergonomics Society 52nd Annual Meeting, 2008. http://www.academia.edu/477435/Monitor_Viewing_Distance_for_Younger_and_Older_Workers. Accessed April 9, 2015. 4. Average of American OSHA, Canadian OSHA and American Optometric Association Recommendations for Computer Monitor Distances. 1 2 PAN15013SKi
  • 41. Benefit #3: less dependence on pupil size1 Features 4.5 mm diffractive zone for less pupil dependence1,2 •Multifocal < 4.0 mm3 •Other trifocals > 5.0 mm4,5 1. PanOptix™ Diffractive Optical Design. Alcon internal technical report: TDOC-0018723. Effective date 19 Dec 2014. 2. AcrySof® IQ PanOptix™ IOL Directions for Use. 3. AcrySof® IQ ReSTOR® +3.0 D IOL Directions for Use. 4. ZEISS AT LISA* IOL Sales Brochure. 5. PhysIOL FineVision* Sales Brochure. *Trademarks are the property of their respective owners. PAN15013SKi
  • 42. Why Diffractive Zone Size matters  4.5 mm = designed to be less dependent on pupil size or lighting conditions • Smaller = May compromise near and intermediate performance in low light or in large-pupil patients • Larger = May compromise contrast sensitivity and impact visual disturbances, such as glare and halo Distanc e PAN15013SKi
  • 43. Hybrid diffractive/refractive trifocal lenses (LISA) Atilisa(zeiss)
  • 44. AT.LISA Principles – SMP-Technology  SMP-Technology (smooth micro phase technology) is a worldwide unique patented technique to create a lens surface  The lens surface does not exhibit any square edges or sharp angles.  Guarantees ideal optical imaging quality without any scattered light  A diffractive focus can be generated which correlates with the theoretically required surface structures of the lens
  • 45. AT LISA Principles Smooth Micro Phase (SMP) Lathing Technology
  • 46. Concept LISA L : Light distributed asymmetrically (between F and N : halos and glare)↓ I : Independency from pupil size S : SMP technology no right angles for reduced light scattering A : Aberration correcting optimized aspheric optic ( contrast sensitivity, depth of field and sharper↑ vision)
  • 47. True Living Vision For excellent optical efficiency by day
  • 48. Extended Depth of Focus (EDOF or EDF) Extended Range of Vision Tecnis Symphony AT Lara (Zeiss) IC8
  • 49. Basic principles of diffractive elements Chromatic aberration
  • 50. Tecnis Symphony  TECNIS Symfony IOL is the first FDA approved lens of its class.[1]  The IOL has a biconvex wavefront-designed anterior aspheric surface and a posterior achromatic diffractive surface with an echelette design.  This proprietary format creates an achromatic diffractive pattern that elongates a single focal point and compensates for the chromatic aberration of the cornea.
  • 51. IC 8 IOL  Applying the same small-aperture principle optics as the KAMRA inlay,the IC-8 IOL incorporates a non-diffractive 3.23 mm diameter opaque mask with a 1.36 mm central aperture embedded within a 6.0 mm one-piece hydrophobic acrylic lens.  The mask creates a pinhole effect, which delivers nearly 3.0 diopters of extended depth of focus by blocking unfocused peripheral light rays and isolating more focused central and paracentral rays through the central aperture2.
  • 52. Maximizing outcomes  Accurate selection of patients  Biometry : Calculation of lens power  Choice of lens model  Con-struction of astigmatically neutral incision  No perfect device available for correction of presbyopia  Patients should have reasonable expectations  Operate on healthy eyes  Best candidates presbyopic hyperopes  Pa-tients who must drive at night not generally good candidates for multifocal IOLs
  • 53. Choice of lens model  Refractive Multifocal IOLs ReZoom: M-flex: Sulcoflex: AF-1 iSii:  Diffractive Multifocal IOLs ReSTOR: spectacle independence of 88% reported TECNIS: 93% spectacle independence reported TECNIS SYMPHONY Acri.LISA:, toric version corrects £12 D PANOPTIX
  • 54. Multifocal IOLs Restore ,Rezoom and …  Accurate preoperative biometry is essential to attaining optimal results with the Multifocal IOLs. Preoperative biometry measurements include axial length and corneal curvature.  Axial Length Use of a IOLMaster (optical biometry ) or standard immersion A-scan is recommended  Keratometry manually or by an automated method.  Personalisation It is important to target emmetropia and to personalise the A constants for all IOLs.  Formula Calculations on patients with axial lengths of between 22 and 25 mm with corneal powers of between 42.00 and 46.00 D will do well with current third-generation formulas (the Holladay 1,SRK/T,and Hoffer Q). For cases outside this range, the Holladay 2 or optimized haigis should be used to ensure accurac  Astigmatism Post-operative astigmatism needs to be reduced to one diopter or less. For patients with astigmatism greater than this, limbal relaxing incisions, LASIK, or other corneal refractive procedures may be needed
  • 55.  Although IOL design is the primary factor in the constant , variation in surgical technique such as The placement of the Iol The location of the incision design of the axiometers and keratometers also affects the personalized lens constant  Most surgeon must perform 20 to 40 cases in order to personalize their lens constant A constant nominal A constant SRKII A constant SRKT Haigis A0 Haigis A1 Haigis A2 P ACD SF Restor SA60D3 118.1 118.7 118.5 -0.123 0.099 0.189 5.23 1.46 Restor SA60D1 118.9 119.3 119.1 0.385 0.197 0.204 5.61 1.83 Acrilisa tri839MP 118.3 119.0 118.9 -1.477 0.058 0.262 5.48 1.72 AMO Tecnis ZMB00 118.8 119.7 119.7 1.73 0.40 0.10 5.96 2.15 Alcon Panoptix TFNT00 119.1 119.3 119.1 1.39 0.40 0.10 5.63 1.83 AMO Tecnis 1 ZCB00 118.8 119.6 119.3 -1.302 0.210 0.251 5.80 2.02 Multifocal IOLs Personalization…
  • 56. Multifocal toric IOLs and online calculation
  • 57. Multifocal toric IOLs and online calculation
  • 58. Multifocal IOLs CHOOSING THE POSTOPERATIVE REFRACTIVE TARGET  Determining the desired postoperative refractive target for multifocal IOLs is slightly different than for monofocal IOLs, where a slight amount of myopia may be beneficial.  With the refractive ReZoom and AcrySof Restor ,Panoptix, Acrilisa or Tecnis multifocal the target should be exactly zero (plano) or the nearest hyperopic choice to zero. Patients' near vision with each of these lenses is excellent, but slight myopia moves the near point too close for comfortable reading.  With the Symphony aim for plano in 1 eye and -0.75 in the second eye to get excellent reading and distance vision  This choice must be discussed with patients, however, especially if they may compare their two eyes for distance.  They should understand the possibility of a slight sacrifice in depth perception to have near vision in one eye.
  • 59.
  • 60. •all diffraction orders occur simultaneously •blazed structures help to suppress disturbing and unwanted orders •unwanted orders create stray light and reduce overall contrast Basic principles of diffractive elements Diffraction orders
  • 61. 61 Diffraction Diffractive Steps  Same step height over whole optic surface ○ Same energy repartition between far/near whatever pupil aperture 02/21/19
  • 62. Diffraction/Refraction 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 Cornea ReSTOR Retina Near focus Distant focus 5 mm pupil Distant object Alcon internal use only - do not distribute!
  • 63. Step width determines the addStep width determines the add power (+4.0D)power (+4.0D) Step height determines theStep height determines the amount of light at near focusamount of light at near focus • Geometry is very important: – Diffractive steps developed to direct the light – The light from every step is focused at near and distant focal points Alcon internal use only - do not distribute!
  • 64. Binocular Defocus Curve Refraction (D) IQ ReSTOR® IOL +3.0 D [N=117] IQ ReSTOR® IOL +4.0 D [N=114] 70 cm (28 in) 50 cm (20 in) 40 cm (16 in) 33 cm (13 in) ∞ 20/25 20/32 20/40 20/50 20/63 20/80 20/100 20/20 +1.00 +0.50 0.00 -0.50 -1.00 -1.50 -2.00 -2.50 -3.00 -3.50 -4.00 Snellen
  • 65. • Optical performance of the ReSTOR +3.0 Aspheric and ReSTOR +4.0 Aspheric IOL are similar Optical Performance Comparison Measured Distance and Near Optical Quality Modified ISO Model Eye MTF @ 100 lp/mm (30 cpd) 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 5mm, distance 3mm, distance MTF ReSTOR® Asph. +4 D (n=10) ReSTOR® Asph. +3 D (n=10)
  • 66. Halo Performance Comparison Line Spread Function generated by near add when viewing distance target  The apodized diffractive optic in the ReSTOR IOLs generates significantly less halos on the bench.  The ReSTOR +3.0 D Aspheric IOL decreases halos on the bench as compared with the existing ReSTOR +4.0 D IOL. Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in model eye with 0.2 um spherical aberration and 5 mm pupil) 0.000 0.050 0.100 0.150 0.200 0.250 0.300 0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24 Image location (mm) Intensityrelativetopeak Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIOL ZM900 Halos Focused distance images Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIultifocal ZM900 (Modified ISO Model Eye with 5 mm pupil) Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis Multifocal ZM900 Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in Modified ISO Model Eye with 5 mm pupil) ® Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in model eye with 0.2 um spherical aberration and 5 mm pupil) 0.000 0.050 0.100 0.150 0.200 0.250 0.300 0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24 Image location (mm) Intensityrelativetopeak Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIOL ZM900 Halos Focused distance images Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIultifocal ZM900 Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in model eye with 0.2 um spherical aberration and 5 mm pupil) 0.000 0.050 0.100 0.150 0.200 0.250 0.300 0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24 Image location (mm) Intensityrelativetopeak Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIOL ZM900 Halos Focused distance images Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in model eye with 0.2 um spherical aberration and 5 mm pupil) 0.000 0.050 0.100 0.150 0.200 0.250 0.300 0.00 0.03 0.06 0.09 0.12 0.15 0.18 0.21 0.24 Image location (mm) Intensityrelativetopeak Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIOL ZM900 Halos Focused distance images Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIultifocal ZM900 Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis MIultifocal ZM900 (Modified ISO Model Eye with 5 mm pupil) Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis Multifocal ZM900 Array SA40N ReSTOR Apsheric +4 D Add ReSTOR Aspheric +3 D Add Current ReSTOR +4 D Add Tecnis Multifocal ZM900 Comparison of measured halos of 3 ReSTOR IOLs to 2 other multifocal IOLs (in Modified ISO Model Eye with 5 mm pupil) ®
  • 67.  Human hair thickness: 60 microns  Red blood cell diameter: 7 microns  Step height at periphery IOL: 0.2 microns Technology of the ReSTOR apodization IOL in ‘human’ terms
  • 68. Add Power Comparison* Spectacle plane IOL & Add Effective Add Reading Distance ReSTOR® 4.0D 3.00D 33.3 cm / 13.5” ReSTOR® 3.0D 2.25D 43.5 cm / 17.8” ReZoom** 3.5D 2.63D 38.5 cm / 15.7” Tecnis** 4.0D 2.66D 37.0 cm / 15.1” * Bench Data: Actual reading distance will depend on biometry, lens* Bench Data: Actual reading distance will depend on biometry, lens position and other patient-related factors. Clinical experience withposition and other patient-related factors. Clinical experience with ReSTORReSTOR 4.0 demonstrated an effective add power of 3.2D.4.0 demonstrated an effective add power of 3.2D. **** ReZoom and Tecnis trademarks of Abbott Medical Optics, Inc.ReZoom and Tecnis trademarks of Abbott Medical Optics, Inc. Alcon internal use only - do not distribute!
  • 69. Optical Principles Principle of Diffraction •Diffraction is the ability of light to bend around edges •Waves are subject to diffraction if they encounter, e.g. Obstruction Aperture •Diffraction depends on wavelength: Green light has a wider wave length than the blue light Therefore the green picture is more expanded than the blue one

Notas do Editor

  1. Birefringence is the optical property of a material having a refractive index that depends on the polarization and propagation direction of light.[1] These optically anisotropic materials are said to be birefringent (or birefractive). The birefringence is often quantified as the maximum difference between refractive indices exhibited by the material. Crystals with asymmetric crystal structures are often birefringent, as are plastics under mechanical stress. Birefringent bifocal lenses are made from materials that have two different refractive indices. Such materials are called «birefringent»., birefringent ophthalmic lenses have never made it to the market, since birefringent soft materials have not been available to date. Diffractive lenses are based upon the wave nature of light. A diffractive bifocal lens is subdivided into a relatively large number of concentric annular zones; and light passing through the different annular zones is brought to interference in a controlled fashion due to optical steps between the zones. The result of such interference is also called a «diffraction pattern», and, consequently, such lenses are referred to as «diffractive lenses » As will be understood, a lens made from a material possessing two refractive indices is a bifocal lens. Examples of birefringent materials are certain types of crystal, such as calcite crystals; also many polymers can be made birefringent by special treatment like stretching. Although the birefringent concept per se is elegant
  2. Key concepts of monofocal lenses: The lens surfaces are smooth and continuous Any break in the surface, or deformation of the lens, creates problems with image quality We sometimes overlook the fact that zonal lenses may affect image quality because of the discontinuities on the lens surface
  3. The Mplus X technology features two major innova- tions compared with the Mplus (Figure 1): additive paraxial asphericity (APA) and surface design optimization (SDO). APA describes a central modification that broadens the two foci into far and near focus zones. The objective of this is to achieve a general enhancement and extension of the depth of focus, not just an improvement of individual focus points. The defocus curve of the Mplus X visualizes the following: Instead of being limited to the maximization of peaks in near, intermediate, and far vision, the Mplus X maximizes the total area under the defocus curve, which corresponds to the entire viewing zone (Figure 2). APA also simplifies neuronal image interpretation by the retinal cones and rods due to intelligent focal modulation. Depending on light condition and pupil size, the APA cre- ates a retinal image that is tailored to the then-prevailing resolutional capability of the retinal pigment epithelium (Figure 3). The second innovation of the Mplus designis called SDO. By enlarging the near vision segment, the Mplus X is now more pupil independent and provides bet- ter reading performance. Second, by minimizing the transi- tion between the two optic zones, light efficiency of more than 95% is achieved (Figure 4). Additionally, the homogeneous optic-haptic transition significantly reduces the incidence of photic phenomena.
  4. The 5 zonal refractive lens is similar to the Array There are alternating near and distance zones Light goes through one of these zones to the power of interest, near or distance making the lens pupil dependent
  5. The optical surface of a Zonal Refractive is not continuous Light spreads out when it hits the optical discontinuities at the zonal boundaries This spreading of light is related to visual disturbances – particularly in night conditions
  6. This illustration on the left depicts the light energy balance transfer curve of a Zonal Refractive lens. It is important to note that this graph does not depict image quality but simply illustrates the distribution of light energy. As illustrated Zonal Refractive lenses are pupil DEPENDENT. When the pupil is near 2 mm (photopic conditions), there is no light distribution to the near focal point This may be counter-intuitive. In a bright lighting situation, with a small (2 mm) pupil, none of the light energy is dedicated to the near image. This may reduce the quality of reading vision in a condition that is traditionally designed for near vision tasks. As the pupil enlarges (mesopic conditions), the pupil allows more light energy to the subsequent zones. KEY POINT: The criss-crossing lines on the graph show the inefficient use of light energy as the pupil increases in size. The image on the right illustrates the two focal points established by the Refractive Zonal lens (on the 1.5 line). The focal points are difficult to distinguish due to the inefficient use of light energy (point to the beams above and below the 1.5 line on the far right side of the graphic). This lost light energy is the cause of the visual disturbances noticed by the patients.
  7. n physics, a wavefront is the locus of points characterized by propagation of positions of identical phase: propagation of a point in 1D, a curve in 2D or a surface in 3D.[1]
  8. Diffraction refers to various phenomena which occur when a wave encounters an obstacle or a slit. In classical physics, the diffraction phenomenon is described as the interference of waves according to the Huygens Frêsenel principle. That mean the plane wave transformed into spherical waves after diffraction. According to Huygens’s principle, light waves incident on two slits will spread out and exhibit an interference pattern in the region beyond Obstacle – Hindernis Encounters – treffen auf
  9. The width between each kinoform step controls the amount of added vergence: from the center to the periphery of the kinoform, the space between each step tend to decrease (as shown by the double yellow arrows). If the steps had the same width, the light energy diffracted in the 1st order would be deviated to another direction in a « parallel » fashion, instead of converging to a distinct foci. The higher the addition (the shorter the distance to 1st order foci), the coarser the rings are, globally. Reciprocally, globally enlarging the spacing between the steps results in a lesser added vergence. Hence, one could think of enlarging the steps until an addition of +1.75 D of vergence is provided.
  10. Apodization is the gradual reduction or blending of diffractive step heights. This technology optimally distributes the appropriate amount of light to near and distant focal points, regardless of the lighting situation.  aim minimizing visual disturbances
  11. This is another way to evaluate the surface structure of the lens. The surface profile has been expanded in one direction here and it has been positioned underneath the energy balance plot for the apodized diffractive lens. The energy balance plot covers pupil diameters from 1 to 6 mm, like the earlier plots for the other lenses. Near the center of the lens, the energy is directed fairly equally to the two lens powers (point), where the diffractive step height is similar to that of a full optic diffractive lens. At the edge of the optic, there is no diffractive structure, and all the light goes to the distance focus. (point). In-between, the diffractive step heights gradually reduce. The lower the step, the lower the proportion of light energy that is directed to the near lens power. For smaller pupils, the energy is fairly evenly divided between the two primary lens powers. As the pupil opens up, more and more energy is directed to the distance lens power. This happens gradually, so that the energy balance gradually changes. For smaller pupils, more energy is available for reading. For larger pupils at night, most of the energy is directed to the distance focus. An additional benefit of apodization is that more of the total light energy is used for the two primary images for larger pupils. A diffractive lens only uses about 82% of the energy for the two primary images, but for larger pupils the outer region is solely refractive, and the total energy utilization increases to over 90% for larger pupils with the ReSTOR lens.
  12. Read directly from the slide.
  13. Put apodization in the end
  14. Here’s a closer look at how the PanOptix™ IOL compares to ZEISS AT Lisa* and PhysIOL FineVision* trifocals in acuity throughout the full range of vision.
  15. Some bifocals or “multifocals” have smaller diffractive zones—such as those under 4 mm. When a patient has naturally large pupils, or if they are simply in low lighting and their pupil dilates to compensate, so much of the distance zone around the periphery of the lens is exposed that distance vision overwhelms the performance of the near and intermediate diffractive zone. All the patient can really see is distance in those conditions. Conversely, with a massive diffractive zone—say more than 5 mm, especially up to 6 mm--it is extremely difficult in dim lighting for enough light to reach the distance zone or zones, so that far distance vision is sacrificed somewhat. But, with a 4.5 mm diffractive zone on a 6 mm optic, the PanOptix™ IOL gives you the best of both worlds. Even when the pupil is large or dilated in low lighting, just enough of the distance zone is exposed to allow patients to see well at all distances.
  16. In this examle you can see that the smaller the step hight, the more light energy is distributet to the 0th diffractive order (blue doted arrows) and less energy to the first diffractive order (yellow doted arrows)
  17. Discuss +3 having 2x the range of near to intermediate vision compared to +4.
  18. Read from the slide